MTPN myotrophin [Homo sapiens] - Gene

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Summary

Official Symbol: MTPNprovided by HGNC
Official Full Name: myotrophinprovided by HGNC
Primary source: HGNC:15667
See related: Ensembl:ENSG00000105887; HPRD:07574; MIM:606484; Vega:OTTHUMG00000155627
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: V-1; GCDP; FLJ31098; FLJ99857
Summary: The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 7q33

Sequence :: Chromosome: 7; NC_000007.13 (135611503..135662204, complement)

See MTPN in Epigenomics, MapViewer

Chromosome 7 - NC_000007.13 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a novel internal ribosome entry site-mediated mechanism may be responsible for the translation of unconventional self-Ag MPD6 in response to IFN-alpha stimulation.
Title: An unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions.
myotrophin/V-1 is a regulatory protein for modulating the levels of activated NFkappaB dimers.
Title: Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P58546	P47756	CAPZB	HPRD	PubMed
P58546	P19838	NFKB1	HPRD	PubMed
P58546	Q04206	RELA	HPRD	PubMed
BioGRID:126455	BioGRID:117313	DSTYK	BioGRID	PubMed	Affinity Capture-MS
BioGRID:126455	BioGRID:111580	MAPK1	BioGRID	PubMed	Two-hybrid
BioGRID:126455	BioGRID:110857	NFKB1	BioGRID	PubMed	Reconstituted Complex
BioGRID:126455	BioGRID:111898	REL	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:126455	BioGRID:111902	RELA	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:126455	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Process	Evidence Code	Pubs
catecholamine metabolic process	IEA Inferred from Electronic Annotation more info
cell growth	IDA Inferred from Direct Assay more info	PubMed
cerebellar granule cell differentiation	IEA Inferred from Electronic Annotation more info
neuron differentiation	NAS Non-traceable Author Statement more info	PubMed
positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of cardiac muscle hypertrophy	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of macromolecule biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of protein metabolic process	ISS Inferred from Sequence or Structural Similarity more info
regulation of barbed-end actin filament capping	IDA Inferred from Direct Assay more info	PubMed
regulation of striated muscle tissue development	NAS Non-traceable Author Statement more info	PubMed
regulation of translation	NAS Non-traceable Author Statement more info	PubMed
skeletal muscle tissue regeneration	IEA Inferred from Electronic Annotation more info
striated muscle cell differentiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
F-actin capping protein complex	IDA Inferred from Direct Assay more info	PubMed
axon	IEA Inferred from Electronic Annotation more info
cellular_component	ND No biological Data available more info
cytoplasm	IEA Inferred from Electronic Annotation more info
cytosol	ISS Inferred from Sequence or Structural Similarity more info
nucleus	ISS Inferred from Sequence or Structural Similarity more info
perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: myotrophin

Names: myotrophin; protein V-1; granule cell differentiation protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145808.3 → NP_665807.1 myotrophin

Status: REVIEWED

Source sequence(s)

AL834231, CB530008, DA325130

Consensus CDS

CCDS5842.1

UniProtKB/Swiss-Prot

P58546

UniProtKB/TrEMBL

Q69YG1

Related

ENSP00000376800, OTTHUMP00000208354, ENST00000393085, OTTHUMT00000340921

Conserved Domains (2) summary

cd00204
Location:6 – 117
Blast Score: 219

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:6 – 97
Blast Score: 213

Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000007.13 Reference GRCh37.p5 Primary Assembly

Range

135611503..135662204, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000139.1 Alternate HuRef

Range

129914553..129965190, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CRA_TCAGchr7v2

Genomic

AC_000068.1 Alternate CRA_TCAGchr7v2

Range

134955940..135006645, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC015987.6 (120715..171270)	None
genomic	CH236950.1	EAL24056.1
genomic	CH471070.1	EAW83859.1
		EAW83860.1
mRNA	AF106075.1	AAP97226.1
mRNA	AK055660.1	None
mRNA	AK056225.1	BAG51651.1
mRNA	AK309816.1	None
mRNA	AL110137.1	None
mRNA	AL834231.1	CAD38909.1
mRNA	BC028093.1	AAH28093.1
mRNA	BC034722.1	None
mRNA	CB530008.1	None
mRNA	DA325130.1	None
other-genetic	AM393216.1	CAL38094.1
other-genetic	AM393266.1	CAL38144.1