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CPE carboxypeptidase E [ Homo sapiens (human) ]

Gene ID: 1363, updated on 22-May-2016
Official Symbol
CPEprovided by HGNC
Official Full Name
carboxypeptidase Eprovided by HGNC
Primary source
HGNC:HGNC:2303
See related
Ensembl:ENSG00000109472 HPRD:00272; MIM:114855; Vega:OTTHUMG00000150252
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPH
Summary
This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]
Orthologs
Location:
4q32.3
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (165378945..165498330)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (166300097..166419482)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene methylsterol monooxygenase 1 Neighboring gene uncharacterized LOC105377519 Neighboring gene microRNA 578 Neighboring gene hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit pseudogene 1 Neighboring gene uncharacterized LOC105377520 Neighboring gene secretoglobin family 1D member 5, pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Arf6 trafficking events, organism-specific biosystem (from Pathway Interaction Database)
    Arf6 trafficking events, organism-specific biosystem
    Arf6 trafficking events
  • Insulin processing, organism-specific biosystem (from REACTOME)
    Insulin processing, organism-specific biosystemThe generation of insulin-containing secretory granules from proinsulin in the lumen of the endoplasmic reticulum (ER) can be described in 4 steps: formation of intramolecular disulfide bonds, format...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
    Peptide hormone metabolism, organism-specific biosystemPeptide hormones are cleaved from larger precursors in the secretory system (endoplasmic reticulum, Golgi apparatus, secretory granules) of the cell. After secretion peptide hormones are modified and...
  • Type I diabetes mellitus, organism-specific biosystem (from KEGG)
    Type I diabetes mellitus, organism-specific biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
  • Type I diabetes mellitus, conserved biosystem (from KEGG)
    Type I diabetes mellitus, conserved biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carboxypeptidase activity TAS
Traceable Author Statement
more info
PubMed 
cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
metallocarboxypeptidase activity TAS
Traceable Author Statement
more info
 
neurexin family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cardiac left ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular protein modification process NAS
Non-traceable Author Statement
more info
PubMed 
insulin processing IBA
Inferred from Biological aspect of Ancestor
more info
 
metabolic process TAS
Traceable Author Statement
more info
PubMed 
neuropeptide signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
protein localization to membrane IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 
synaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
carboxypeptidase E
Names
carboxypeptidase H
cobalt-stimulated chromaffin granule carboxypeptidase
enkephalin convertase
insulin granule-associated carboxypeptidase
prohormone-processing carboxypeptidase
NP_001864.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001873.3NP_001864.1  carboxypeptidase E preproprotein

    See identical proteins and their annotated locations for NP_001864.1

    Status: REVIEWED

    Source sequence(s)
    AA683379, AA883804, AC012504, X51405
    Consensus CDS
    CCDS3810.1
    UniProtKB/Swiss-Prot
    P16870
    Related
    ENSP00000386104, OTTHUMP00000196776, ENST00000402744, OTTHUMT00000317094
    Conserved Domains (2) summary
    cd03865
    Location:49371
    M14_CPE; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase E subgroup
    cd11308
    Location:375449
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

    Range
    165378945..165498330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    166276542..166396001
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)