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    Eef2 eukaryotic translation elongation factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 13629, updated on 5-May-2013
    Official Symbol
    Eef2provided by MGI
    Official Full Name
    eukaryotic translation elongation factor 2provided by MGI
    Primary source
    MGI:95288
    See related
    Ensembl:ENSMUSG00000034994
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ef-2
    Location :
    10 C1; 10
    Sequence :
    Chromosome: 10; NC_000076.6 (81176631..81182509)
    See Eef2 in Epigenomics, MapViewer

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 7a Neighboring gene protein inhibitor of activated STAT 4 Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene predicted gene, 19886 Neighboring gene death-associated protein kinase 3 Neighboring gene RIKEN cDNA 2310050B05 gene Neighboring gene nicotinamide riboside kinase 2

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description
    NC_000076.1 Cdk8    BIND  PubMed An unspecified isoform of CDK8 interacts with EF2p. 
    NC_000076.1 NP_613046.1 Nelfe    BIND  PubMed NELF interacts with EF2p. 
    NC_000076.1 NP_035547.1 Smarca4    BIND  PubMed BRG1 interacts with EF2p. 
    NC_000076.1 NP_038712.1 Tbp    BIND  PubMed TBP interacts with EF2p. 
    BioGRID:199387 BioGRID:205013 Cul3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199387 BioGRID:212401 Fbxo32    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199387 BioGRID:235913 Iqcb1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199387 BioGRID:207511 Nphp1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199387 BioGRID:201823 Npm1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199387 BioGRID:202313 Pou5f1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199387 BioGRID:204307 Traf6    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 

    Markers

    Homology

    Clone Names

    • MGC98463

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IDA
    Inferred from Direct Assay
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
     
    translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    GTP catabolic process IDA
    Inferred from Direct Assay
    more info
     
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    translational elongation IDA
    Inferred from Direct Assay
    more info
     
    translational elongation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    polysome IDA
    Inferred from Direct Assay
    more info
     
    ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    elongation factor 2
    Names
    elongation factor 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007907.2NP_031933.1  elongation factor 2

      Status: VALIDATED

      Source sequence(s)
      AK168794, CJ170931, CJ316208
      Consensus CDS
      CCDS35993.1
      UniProtKB/Swiss-Prot
      P58252
      Related
      ENSMUSP00000046101, ENSMUST00000047864
      Conserved Domains (5) summary
      cd04096
      Location:742821
      Blast Score: 385
      eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
      cd03700
      Location:394487
      Blast Score: 371
      eEF2_snRNP_like_II; EF2_snRNP_like_II: this subfamily represents domain II of elongation factor (EF) EF-2 found eukaryotes and archaea and, the C-terminal portion of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast ...
      cd01681
      Location:574746
      Blast Score: 749
      aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
      PTZ00416
      Location:1858
      Blast Score: 3964
      PTZ00416; elongation factor 2; Provisional
      cd01885
      Location:20233
      Blast Score: 779
      EF2; Elongation Factor 2 (EF2) in archaea and eukarya

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p1 C57BL/6J

      Range
      81176631..81182509
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000032.1 Alternate Mm_Celera

      Range
      82196988..82202866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

      Supplemental Content

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