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S1pr4 sphingosine-1-phosphate receptor 4 [ Mus musculus (house mouse) ]

Gene ID: 13611, updated on 4-May-2015
Official Symbol
S1pr4provided by MGI
Official Full Name
sphingosine-1-phosphate receptor 4provided by MGI
Primary source
MGI:MGI:1333809
See related
Ensembl:ENSMUSG00000044199
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Edg6; Lpc1; S1p4
Summary
This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for the lysophospholipid sphingosine 1-phosphate. The encoded protein is one of the predominant sphingosine 1-phosphate G-protein coupled receptors expressed in T cells, and it plays a role in suppression of T cell proliferation, generation of cytokines, and potentially other aspects of immune activation. [provided by RefSeq, Feb 2010]
Orthologs
See S1pr4 in MapViewer
Location:
10; 10 C1
Exon count:
1
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (81497745..81500137, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (80960490..80962882, complement)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene CUGBP, Elav-like family member 5 Neighboring gene nicalin homolog (zebrafish) Neighboring gene guanine nucleotide binding protein, alpha 15 Neighboring gene guanine nucleotide binding protein, alpha 11

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Clone Names

  • MGC129298

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G-protein coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
sphingosine-1-phosphate receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
sphingosine 1-phosphate receptor 4
Names
sphingosine 1-phosphate receptor 4
S1P receptor Edg-6
S1p receptor 4
endothelial differentiation G-protein coupled receptor 6
endothelial differentiation G-protein-coupled receptor 6
lysophospholipid receptor C1
sphingosine 1-phosphate receptor Edg-6

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010102.2NP_034232.1  sphingosine 1-phosphate receptor 4

    See identical proteins and their annotated locations for NP_034232.1

    Status: REVIEWED

    Source sequence(s)
    AC159474
    Consensus CDS
    CCDS24059.1
    UniProtKB/Swiss-Prot
    Q9Z0L1
    Related
    ENSMUSP00000050412, ENSMUST00000053646
    Conserved Domains (1) summary
    pfam00001
    Location:72309
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

    Range
    81497745..81500137
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000032.1 Alternate Mm_Celera

    Range
    82521128..82523520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)