S1pr1 sphingosine-1-phosphate receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Go to the top of the page Help

Official Symbol: S1pr1provided by MGI
Official Full Name: sphingosine-1-phosphate receptor 1provided by MGI
Primary source: MGI:1096355
See related: Ensembl:ENSMUSG00000045092
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: S1p; Edg1; Lpb1; S1p1; AI849002
Summary: This gene encodes a G-protein-coupled receptor bound by the lysophospholipid, sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. This receptor is highly expressed in T and B lymphocytes, and it plays a role in T cell and B cell export from peripheral lymphoid organs. This protein is bound and downregulated by FTY720, an exogenous immunosuppressant drug studied in mouse disease models for multiple sclerosis in humans. [provided by RefSeq, Jan 2010]

Genomic context

Go to the top of the page Help

Location :: 3 G1; 3

Sequence :: Chromosome: 3; NC_000069.6 (115710433..115715055, complement)

See S1pr1 in Epigenomics, MapViewer

Chromosome 3 - NC_000069.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathways
Title: Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathways.
Findings sugget that type 1 sphingosine 1-phosphate (S1P1) antagonism is responsible for lymphocyte sequestration from the blood.
Title: Lymphopenia induced by a novel selective S1P(1) antagonist structurally unrelated to S1P.
these results reveal that SphK1/S1PR1 signalling axis is induced by TGF-beta1 and stimulates cell migration in RAW 264.7 macrophages.
Title: Sphingosine kinase-1/sphingosine-1-phosphate receptor type 1 signalling axis is induced by transforming growth factor-β1 and stimulates cell migration in RAW264.7 macrophages.
The S1P-S1pr1 axis is a master regulator of efficient thrombopoiesis.
Title: A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis.
A selective S1P receptor type 1 agonist CYM5442 on atherosclerosis.
Title: Effect of sphingosine 1-phosphate (S1P) receptor agonists FTY720 and CYM5442 on atherosclerosis development in LDL receptor deficient (LDL-R⁻/⁻) mice.
The S1PR1 signaling acts as a vascular-intrinsic stabilization mechanism, protecting developing blood vessels against aberrant angiogenic responses.
Title: The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2.
findings show that S1P1 acts as an endothelial cell (EC)-autonomous negative regulator of sprouting angiogenesis during vascular development
Title: S1P1 inhibits sprouting angiogenesis during vascular development.
Persistent activated STAT3 colocalizes with elevated expression of S1PR1, a G-protein-coupled receptor for sphingosine-1-phosphate (S1P), in the tumor cells of the activated B cell-like subtype of diffuse large B-cell lymphoma.
Title: S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma.
Proximal cerebral arteries develop myogenic responsiveness in heart failure via tumor necrosis factor-alpha-dependent activation of sphingosine-1-phosphate signaling.
Title: Proximal cerebral arteries develop myogenic responsiveness in heart failure via tumor necrosis factor-α-dependent activation of sphingosine-1-phosphate signaling.
These results indicate that S1P receptor-mediated signaling plays a crucial role for osteoblast differentiation.
Title: Sphingosine 1-phosphate receptor activation enhances BMP-2-induced osteoblast differentiation.

Submit: New GeneRIF Correction See all (62)

Alleles

Go to the top of the page Help

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (3) 1 citation
Targeted (Reporter) (2) 1 citation
Targeted (knock-in) (3) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:199373	BioGRID:200857	Jak2		BioGRID	PubMed	Affinity Capture-Western
BioGRID:199373	BioGRID:203491	Src		BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

Go to the top of the page Help

Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
Class A/1 (Rhodopsin-like receptors), organism-specific biosystemcomputationally inferred pathway (not manually curated)
G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
G alpha (i) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR ligand binding, organism-specific biosystem (from REACTOME)
GPCR ligand binding, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCRs, Other, organism-specific biosystem (from WikiPathways)
GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
Lysosphingolipid and LPA receptors, organism-specific biosystem (from REACTOME)
Lysosphingolipid and LPA receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
Neuroactive ligand-receptor interaction, organism-specific biosystem
Neuroactive ligand-receptor interaction
Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
Neuroactive ligand-receptor interaction, conserved biosystem
Neuroactive ligand-receptor interaction
Non-odorant GPCRs, organism-specific biosystem (from WikiPathways)
Non-odorant GPCRs, organism-specific biosystemListing of non-odorant Mouse GCPRs by coupling.
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction of S1P Receptor, organism-specific biosystem (from WikiPathways)
Signal Transduction of S1P Receptor, organism-specific biosystem
Signal Transduction of S1P Receptor
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Small Ligand GPCRs, organism-specific biosystem (from WikiPathways)
Small Ligand GPCRs, organism-specific biosystem
Small Ligand GPCRs

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:225110

Edg1 (e-PCR), detects polymorphism
- UniSTS:474712

EDG1 (e-PCR)
- UniSTS:266357

Edg1 (e-PCR), detects polymorphism
- UniSTS:496523

RH129877 (e-PCR)
- UniSTS:213165

Edg1 (e-PCR), detects polymorphism
- UniSTS:209582

AI849002 (e-PCR)
- UniSTS:178920

Homology

Homologs of the S1pr1 gene: The S1pr1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
G-protein coupled receptor activity	ISO Inferred from Sequence Orthology more info
signal transducer activity	IEA Inferred from Electronic Annotation more info
sphingolipid binding	ISO Inferred from Sequence Orthology more info
sphingosine-1-phosphate receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
G-protein coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
angiogenesis	IDA Inferred from Direct Assay more info	PubMed
brain development	IMP Inferred from Mutant Phenotype more info	PubMed
elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway	ISO Inferred from Sequence Orthology more info
negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
positive regulation of Ras GTPase activity	ISO Inferred from Sequence Orthology more info
positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
positive regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of positive chemotaxis	ISO Inferred from Sequence Orthology more info
positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
signal transduction	IEA Inferred from Electronic Annotation more info
sphingosine-1-phosphate signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
external side of plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: sphingosine 1-phosphate receptor 1

Names: sphingosine 1-phosphate receptor 1; S1P receptor 1; S1P receptor Edg-1; lysophospholipid receptor B1; sphingosine 1-phosphate receptor Edg-1; endothelial differentiation G-protein coupled receptor 1; endothelial differentiation sphingolipid G-protein-coupled receptor 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007901.5 → NP_031927.2 sphingosine 1-phosphate receptor 1

Status: REVIEWED

Source sequence(s)

AC126932, AK004591

Consensus CDS

CCDS17781.1

UniProtKB/Swiss-Prot

O08530

Related

ENSMUSP00000050897, ENSMUST00000055676

Conserved Domains (1) summary

pfam00001
Location:68 – 311
Blast Score: 373

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000069.6 Reference GRCm38.p1 C57BL/6J

Range

115710433..115715055, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000025.1 Alternate Mm_Celera

Range

122144261..122148908, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01030657.1 (590..5237)	None
genomic	AC126932.4 (127972..132594)	None
genomic	AF108019.1	AAD16975.1	129/SvJ
genomic	AY011706.1	AAK01975.1
genomic	CH466532.2	EDL12402.1	mixed
genomic	U40811.1	AAC53294.1
mRNA	AK004591.2	BAB23393.1	C57BL/6J
mRNA	AK082672.1	BAC38569.1	C57BL/6J
mRNA	AK138316.1	BAE23622.1	C57BL/6J
mRNA	AK146501.1	BAE27216.1	C57BL/6J
mRNA	BC049094.1	AAH49094.1	C57BL/6
mRNA	BC051023.1	AAH51023.1