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Eda ectodysplasin-A [ Mus musculus (house mouse) ]

Gene ID: 13607, updated on 8-May-2016
Official Symbol
Edaprovided by MGI
Official Full Name
ectodysplasin-Aprovided by MGI
Primary source
MGI:MGI:1195272
See related
Ensembl:ENSMUSG00000059327 Vega:OTTMUSG00000018058
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ta; Ed1; HED; EDA1; XLHED; tabby; Eda-A1; Eda-A2; Tnlg7c
Orthologs
Location:
X C3; X 43.59 cM
Exon count:
10
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) X NC_000086.7 (99975606..100400760)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (97170945..97596099)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene proliferating cell nuclear antigen pseudogene 1 Neighboring gene transmembrane protein 28 Neighboring gene zinc finger, FYVE domain containing 19 pseudogene Neighboring gene serologically defined colon cancer antigen 3 pseudogene Neighboring gene microRNA 676 Neighboring gene acyl-CoA wax alcohol acyltransferase 2 Neighboring gene OTU domain containing 6A Neighboring gene immunoglobulin (CD79A) binding protein 1 Neighboring gene diacylglycerol O-acyltransferase 2-like 6

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (14)  1 citation
  • Chemically and radiation induced (2) 
  • Radiation induced (5) 
  • Chemically induced (ENU) (2)  1 citation
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
hair follicle development IGI
Inferred from Genetic Interaction
more info
PubMed 
hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
hair follicle placode formation IGI
Inferred from Genetic Interaction
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
PubMed 
pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of NF-kappaB import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
salivary gland cavitation IDA
Inferred from Direct Assay
more info
PubMed 
skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
trachea gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
collagen trimer IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
ectodysplasin-A
Names
EDA protein homolog
tumor necrosis factor ligand 7c

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177937.1NP_001171408.1  ectodysplasin-A isoform 2

    See identical proteins and their annotated locations for NP_001171408.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame small segment in the CDS, as compared to variant 1. The resulting isoform (2) lacks two internal aa, as compared to isoform 1.
    Source sequence(s)
    AF016627, AJ243657, CJ207760, DQ168876
    UniProtKB/Swiss-Prot
    O54693
    UniProtKB/TrEMBL
    A0A0U5J8Q0, Q3UV69
    Conserved Domains (1) summary
    cd00184
    Location:249381
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
  2. NM_001177938.1NP_001171409.1  ectodysplasin-A isoform 3

    See identical proteins and their annotated locations for NP_001171409.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame small segment in the CDS, as compared to variant 1. The resulting isoform (3) lacks three internal aa, as compared to isoform 1.
    Source sequence(s)
    CJ207760, DQ168877
    UniProtKB/TrEMBL
    Q1L2E0
    Conserved Domains (1) summary
    cd00184
    Location:249380
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
  3. NM_001177939.1NP_001171410.1  ectodysplasin-A isoform 4

    See identical proteins and their annotated locations for NP_001171410.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two in-frame small segments in the CDS, as compared to variant 1. The resulting isoform (4) lacks five internal aa, as compared to isoform 1.
    Source sequence(s)
    AF016627, AJ243658, CJ207760, DQ168876
    Consensus CDS
    CCDS53143.1
    UniProtKB/Swiss-Prot
    O54693
    UniProtKB/TrEMBL
    Q3UV69
    Related
    ENSMUSP00000109408, OTTMUSP00000019658, ENSMUST00000113778, OTTMUST00000043780
    Conserved Domains (1) summary
    cd00184
    Location:249378
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
  4. NM_001177940.1NP_001171411.1  ectodysplasin-A isoform 5

    See identical proteins and their annotated locations for NP_001171411.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (5) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    CJ207760, DQ168878
    Consensus CDS
    CCDS53144.1
    UniProtKB/TrEMBL
    Q1L2D9
    Related
    ENSMUSP00000071397, ENSMUST00000071453
    Conserved Domains (1) summary
    cd00184
    Location:241375
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
  5. NM_001177941.1NP_001171412.1  ectodysplasin-A isoform 6

    See identical proteins and their annotated locations for NP_001171412.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an in-frame exon and two in-frame small segments in the CDS, as compared to variant 1. The resulting isoform (6) is shorter but has the same N- and C-termini, as compared to isoform 1.
    Source sequence(s)
    CJ207760, DQ168879
    Consensus CDS
    CCDS53145.1
    UniProtKB/TrEMBL
    Q1L2D8
    Related
    ENSMUSP00000109411, OTTMUSP00000019659, ENSMUST00000113781, OTTMUST00000043781
    Conserved Domains (1) summary
    cd00184
    Location:241370
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
  6. NM_001177942.1NP_001171413.1  ectodysplasin-A isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an in-frame segment in the CDS, as compared to variant 1. The resulting isoform (7) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AF004435, CJ207760, DQ168876
    Consensus CDS
    CCDS53141.1
    UniProtKB/Swiss-Prot
    O54693
    UniProtKB/TrEMBL
    Q3UV69
    Related
    ENSMUSP00000109410, OTTMUSP00000019657, ENSMUST00000113780, OTTMUST00000043779
    Conserved Domains (1) summary
    pfam00229
    Location:286371
    TNF; TNF(tumor Necrosis Factor) family
  7. NM_001177943.1NP_001171414.1  ectodysplasin-A isoform 8

    See identical proteins and their annotated locations for NP_001171414.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks a small segment but has an additional exon in the CDS, as compared to variant 1. The resulting isoform (8) is shorter and has a different C-terminus, as compared to isoform 1.
    Source sequence(s)
    CJ207760, DQ168880
    Consensus CDS
    CCDS53142.1
    UniProtKB/TrEMBL
    Q1L2D6
    Related
    ENSMUSP00000109406, OTTMUSP00000019584, ENSMUST00000113776, OTTMUST00000043584
    Conserved Domains (1) summary
    cl00147
    Location:249309
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
  8. NM_001177944.1NP_001171415.1  ectodysplasin-A isoform 8

    See identical proteins and their annotated locations for NP_001171415.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks a small segment but has an additional exon in the CDS, as compared to variant 1. The resulting isoform (8) is shorter and has a different C-terminus, as compared to isoform 1.
    Source sequence(s)
    CJ207760, DQ168881
    Consensus CDS
    CCDS53142.1
    UniProtKB/TrEMBL
    Q1L2D6
    Related
    ENSMUSP00000109405, OTTMUSP00000019656, ENSMUST00000113775, OTTMUST00000043778
    Conserved Domains (1) summary
    cl00147
    Location:249309
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
  9. NM_010099.2NP_034229.1  ectodysplasin-A isoform 1

    See identical proteins and their annotated locations for NP_034229.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL671299, AL671979, AL773561
    Consensus CDS
    CCDS30299.1
    UniProtKB/Swiss-Prot
    O54693
    UniProtKB/TrEMBL
    Q3UV69
    Related
    ENSMUSP00000109409, OTTMUSP00000019583, ENSMUST00000113779, OTTMUST00000043583
    Conserved Domains (1) summary
    cd00184
    Location:249383
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p3 C57BL/6J

    Range
    99975606..100400760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527778.2XP_006527841.1  

    See identical proteins and their annotated locations for XP_006527841.1

    Conserved Domains (1) summary
    pfam00229
    Location:140253
    TNF; TNF(tumor Necrosis Factor) family

Alternate Mm_Celera

Genomic

  1. AC_000042.1 Alternate Mm_Celera

    Range
    86912424..87326326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)