Eda ectodysplasin-A [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Edaprovided by MGI
Official Full Name: ectodysplasin-Aprovided by MGI
Primary source: MGI:1195272
Locus tag: RP23-281K21.1
See related: Ensembl:ENSMUSG00000059327; Vega:OTTMUSG00000018058
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ta; Ed1; HED; EDA1; XLHED; tabby; Eda-A1; Eda-A2

Genomic context

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Location :: X C3; X 43.59 cM

Sequence :: Chromosome: X; NC_000086.7 (99975606..100400760)

See Eda in Epigenomics, MapViewer

Chromosome X - NC_000086.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling.
Title: Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling.
NF-kappaB downstream of the TNF-like ligand ectodysplasin (Eda) is identified as a unique regulator of embryonic and prepubertal ductal morphogenesis.
Title: Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-κB.
Data found that Eda regulates growth and branching of the SMG via transcription factor NF-kappaB in the epithelium, and that the hedgehog pathway is an important mediator of Eda/NF-kappaB.
Title: Ectodysplasin and Wnt pathways are required for salivary gland branching morphogenesis.
Dkk4 affects an auxiliary pathway for Eda-independent development of secondary hair
Title: Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair.
Treatment of Eda-/- minor salivary gland explants with EDA A1 rescues minor salivary gland induction.
Title: Defects and rescue of the minor salivary glands in Eda pathway mutants.
The collagen domain activates EDA1 by multimerization, whereas the proteoglycan-binding domain may restrict the distribution of endogeneous EDA1 in vivo.
Title: Biological activity of ectodysplasin A is conditioned by its collagen and heparan sulfate proteoglycan-binding domains.
These data reveal a complex interplay and interdependence of Wnt/beta-catenin and EDA/EDAR/NF-kappaB signaling pathways in initiation and maintenance of primary hair follicle placodes.
Title: Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction.
Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda protein
Title: Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm.
results indicate that unknown mechanisms of the Eda pathway are implicated in tooth morphogenesis
Title: Distinct impacts of Eda and Edar loss of function on the mouse dentition.
The upper jaw is more sensitive than the lower jaw to the loss of eda function. Modifications in cusp number and the abnormal crown size of the teeth are clearly linked, and our results indicate a role of eda in cusp patterning.
Title: Effect of eda loss of function on upper jugal tooth morphology.

Submit: New GeneRIF Correction See all (29)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (13) 1 citation
Chemically and radiation induced (2)
Radiation induced (5)
Chemically induced (ENU) (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:199371	BioGRID:116118	EDAR		BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...

General gene information

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Markers

PMC24264P1 (e-PCR)
- UniSTS:272245

PMC24264P2 (e-PCR)
- UniSTS:272246

PMC24264P3 (e-PCR)
- UniSTS:272247

PMC24264P4 (e-PCR)
- UniSTS:272248

AF016628 (e-PCR)
- UniSTS:160892

Eda (e-PCR), detects polymorphism
- UniSTS:275864

px-7h4 (e-PCR)
- UniSTS:258461

mHAa21e2.seq (e-PCR)
- UniSTS:125944

Homology

Homologs of the Eda gene: The Eda gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
receptor binding	ISO Inferred from Sequence Orthology more info
tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cell differentiation	IEA Inferred from Electronic Annotation more info
cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
hair follicle development	IGI Inferred from Genetic Interaction more info	PubMed
hair follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
hair follicle placode formation	IGI Inferred from Genetic Interaction more info	PubMed
immune response	IEA Inferred from Electronic Annotation more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
odontogenesis of dentin-containing tooth	IMP Inferred from Mutant Phenotype more info	PubMed
pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of I-kappaB kinase/NF-kappaB cascade	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of NF-kappaB import into nucleus	IDA Inferred from Direct Assay more info	PubMed
positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
positive regulation of canonical Wnt receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
salivary gland cavitation	IDA Inferred from Direct Assay more info	PubMed
skin development	IMP Inferred from Mutant Phenotype more info	PubMed
trachea gland development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
apical part of cell	IDA Inferred from Direct Assay more info	PubMed
collagen	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
extracellular region	IEA Inferred from Electronic Annotation more info
integral to membrane	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ectodysplasin-A

Names: ectodysplasin-A; EDA protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177937.1 → NP_001171408.1 ectodysplasin-A isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame small segment in the CDS, as compared to variant 1. The resulting isoform (2) lacks two internal aa, as compared to isoform 1.

Source sequence(s)

AF016627, AJ243657, CJ207760, DQ168876

UniProtKB/Swiss-Prot

O54693

UniProtKB/TrEMBL

Q3UV69

Conserved Domains (1) summary

cd00184
Location:249 – 381
Blast Score: 177

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
NM_001177938.1 → NP_001171409.1 ectodysplasin-A isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an in-frame small segment in the CDS, as compared to variant 1. The resulting isoform (3) lacks three internal aa, as compared to isoform 1.

Source sequence(s)

CJ207760, DQ168877

UniProtKB/TrEMBL

Q1L2E0

Conserved Domains (1) summary

cd00184
Location:249 – 380
Blast Score: 184

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
NM_001177939.1 → NP_001171410.1 ectodysplasin-A isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two in-frame small segments in the CDS, as compared to variant 1. The resulting isoform (4) lacks five internal aa, as compared to isoform 1.

Source sequence(s)

AF016627, AJ243658, CJ207760, DQ168876

Consensus CDS

CCDS53143.1

UniProtKB/Swiss-Prot

O54693

UniProtKB/TrEMBL

Q3UV69

Related

ENSMUSP00000109408, OTTMUSP00000019658, ENSMUST00000113778, OTTMUST00000043780

Conserved Domains (1) summary

cd00184
Location:249 – 378
Blast Score: 186

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
NM_001177940.1 → NP_001171411.1 ectodysplasin-A isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (5) lacks an internal segment, as compared to isoform 1.

Source sequence(s)

CJ207760, DQ168878

Consensus CDS

CCDS53144.1

UniProtKB/TrEMBL

Q1L2D9

Related

ENSMUSP00000109413, OTTMUSP00000019949, ENSMUST00000113783, OTTMUST00000044402

Conserved Domains (1) summary

cd00184
Location:241 – 375
Blast Score: 176

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
NM_001177941.1 → NP_001171412.1 ectodysplasin-A isoform 6

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks an in-frame exon and two in-frame small segments in the CDS, as compared to variant 1. The resulting isoform (6) is shorter but has the same N- and C-termini, as compared to isoform 1.

Source sequence(s)

CJ207760, DQ168879

Consensus CDS

CCDS53145.1

UniProtKB/TrEMBL

Q1L2D8

Related

ENSMUSP00000109411, OTTMUSP00000019659, ENSMUST00000113781, OTTMUST00000043781

Conserved Domains (1) summary

cd00184
Location:241 – 370
Blast Score: 187

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
NM_001177942.1 → NP_001171413.1 ectodysplasin-A isoform 7

Status: VALIDATED

Description

Transcript Variant: This variant (7) lacks an in-frame segment in the CDS, as compared to variant 1. The resulting isoform (7) lacks an internal segment, as compared to isoform 1.

Source sequence(s)

AF004435, CJ207760, DQ168876

Consensus CDS

CCDS53141.1

UniProtKB/Swiss-Prot

O54693

UniProtKB/TrEMBL

Q3UV69

Related

ENSMUSP00000109410, OTTMUSP00000019657, ENSMUST00000113780, OTTMUST00000043779

Conserved Domains (1) summary

pfam00229
Location:286 – 371
Blast Score: 160

TNF; TNF(Tumour Necrosis Factor) family
NM_001177943.1 → NP_001171414.1 ectodysplasin-A isoform 8

Status: VALIDATED

Description

Transcript Variant: This variant (8) lacks a small segment but has an additional exon in the CDS, as compared to variant 1. The resulting isoform (8) is shorter and has a different C-terminus, as compared to isoform 1.

Source sequence(s)

CJ207760, DQ168880

Consensus CDS

CCDS53142.1

UniProtKB/TrEMBL

Q1L2D6

Related

ENSMUSP00000109406, OTTMUSP00000019584, ENSMUST00000113776, OTTMUST00000043584

Conserved Domains (1) summary

cl00147
Location:249 – 309
Blast Score: 81

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
NM_001177944.1 → NP_001171415.1 ectodysplasin-A isoform 8

Status: VALIDATED

Description

Transcript Variant: This variant (9) lacks a small segment but has an additional exon in the CDS, as compared to variant 1. The resulting isoform (8) is shorter and has a different C-terminus, as compared to isoform 1.

Source sequence(s)

CJ207760, DQ168881

Consensus CDS

CCDS53142.1

UniProtKB/TrEMBL

Q1L2D6

Related

ENSMUSP00000109405, OTTMUSP00000019656, ENSMUST00000113775, OTTMUST00000043778

Conserved Domains (1) summary

cl00147
Location:249 – 309
Blast Score: 81

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
NM_010099.2 → NP_034229.1 ectodysplasin-A isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AL671299, AL671979, AL773561

Consensus CDS

CCDS30299.1

UniProtKB/Swiss-Prot

O54693

UniProtKB/TrEMBL

Q3UV69

Related

ENSMUSP00000109409, OTTMUSP00000019583, ENSMUST00000113779, OTTMUST00000043583

Conserved Domains (1) summary

cd00184
Location:249 – 383
Blast Score: 175

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000086.7 Reference GRCm38.p1 C57BL/6J

Range

99975606..100400760

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000042.1 Alternate Mm_Celera

Range

86912424..87326326

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01214936.1	None
genomic	AAHY01214937.1	None
genomic	AAHY01214938.1	None
genomic	AAHY01214939.1	None
genomic	AAHY01214940.1	None
genomic	AAHY01214941.1	None
genomic	AAHY01214942.1	None
genomic	AAHY01214943.1	None
genomic	AAHY01214944.1	None
genomic	AAHY01214945.1	None
genomic	AAHY01214946.1	None
genomic	AAHY01214947.1	None
genomic	AAHY01214948.1	None
genomic	AAHY01214949.1	None
genomic	AAHY01214950.1	None
genomic	AAHY01214951.1	None
genomic	AAHY01214952.1	None
genomic	AAHY01214953.1	None
genomic	AAHY01214954.1	None
genomic	AAHY01214955.1	None
genomic	AAHY01214956.1	None
genomic	AAHY01214957.1	None
genomic	AAHY01214958.1	None
genomic	AAHY01214959.1	None
genomic	AAHY01214960.1	None
genomic	AAHY01214961.1	None
genomic	AAHY01214962.1	None
genomic	AAHY01214963.1	None
genomic	AAHY01214964.1	None
genomic	AAHY01214965.1	None
genomic	AAHY01214966.1	None
genomic	AAHY01214967.1	None
genomic	AAHY01214968.1	None
genomic	AAHY01214969.1	None
genomic	AAHY01214970.1	None
genomic	AAHY01214971.1	None
genomic	AAHY01214972.1	None
genomic	AAHY01214973.1	None
genomic	AAHY01214974.1	None
genomic	AAHY01214975.1	None
genomic	AAHY01214976.1	None
genomic	AAHY01214977.1	None
genomic	AAHY01214978.1	None
genomic	AAHY01214979.1	None
genomic	AAHY01214980.1 (27206..30227)	None
genomic	AF004434.1	AAB88121.1	129
genomic	AF016632.1	None
genomic	AL671299.18 (2000..6176)	None
genomic	AL671979.5 (2000..154170)	None
genomic	AL773561.7 (77959..174072)	None
genomic	BX005452.7 (2001..167118)	None
genomic	BX890547.2 (2001..9578)	None
genomic	CH466564.2	EDL14185.1	mixed
		EDL14186.1	mixed
genomic	Y13438.1	CAA73849.1	129/Sv
mRNA	AF004435.1	AAB88122.1
mRNA	AF016627.1	AAB95202.1
mRNA	AF016628.1	AAB95203.1
mRNA	AF016629.1	AAB95204.1
mRNA	AF016630.1	AAB95205.1
mRNA	AF016631.1	AAB95206.1
mRNA	AJ243657.1	CAB52696.1
mRNA	AJ243658.1	CAB52697.1
mRNA	AK028502.1	None	C57BL/6J
mRNA	AK040754.1	None	C57BL/6J
mRNA	AK137551.1	BAE23404.1	C57BL/6J
mRNA	BC125387.1	AAI25388.1
mRNA	BC144790.1	AAI44791.1
mRNA	BC144791.1	AAI44792.1
mRNA	CJ207760.1	None	C57BL/6J
mRNA	DQ168876.1	ABB59616.1	C57BL/6
mRNA	DQ168877.1	ABB59617.1	C57BL/6
mRNA	DQ168878.1	ABB59618.1	C57BL/6
mRNA	DQ168879.1	ABB59619.1	C57BL/6
mRNA	DQ168880.1	ABB59620.1	C57BL/6
mRNA	DQ168881.1	ABB59621.1	C57BL/6