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HUS1B HUS1 checkpoint clamp component B [ Homo sapiens (human) ]

Gene ID: 135458, updated on 26-May-2016
Official Symbol
HUS1Bprovided by HGNC
Official Full Name
HUS1 checkpoint clamp component Bprovided by HGNC
Primary source
HGNC:HGNC:16485
See related
Ensembl:ENSG00000188996 HPRD:13722; MIM:609713; Vega:OTTHUMG00000090059
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check point protein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to the HUS1. [provided by RefSeq, Jul 2008]
Orthologs
Location:
6p25.3
Exon count:
1
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (655939..656964, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (655939..656964, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374875 Neighboring gene exocyst complex component 2 Neighboring gene uncharacterized LOC105374874 Neighboring gene microtubule affinity regulating kinase 2 pseudogene Neighboring gene uncharacterized LOC105374873

NHGRI GWAS Catalog

Description
Linkage and association of successful aging to the 6q25 region in large Amish kindreds.
NHGRI GWA Catalog
  • DNA damage response, organism-specific biosystem (from WikiPathways)
    DNA damage response, organism-specific biosystemThis is the first pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). The two ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC126746, MGC126748

Gene Ontology Provided by GOA

Process Evidence Code Pubs
double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
intra-S DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
 
meiotic DNA integrity checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
 
mitotic DNA replication checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
checkpoint clamp complex IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
checkpoint protein HUS1B
Names
HUS1 checkpoint homolog b
hHUS1B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_148959.3NP_683762.2  checkpoint protein HUS1B

    See identical proteins and their annotated locations for NP_683762.2

    Status: REVIEWED

    Source sequence(s)
    AL357054, BC101699
    Consensus CDS
    CCDS4470.1
    UniProtKB/Swiss-Prot
    Q8NHY5
    Related
    ENSP00000370293, OTTHUMP00000114799, ENST00000380907, OTTHUMT00000205617
    Conserved Domains (1) summary
    pfam04005
    Location:1278
    Hus1; Hus1-like protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    655939..656964 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    658066..659091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)