Dvl1 dishevelled, dsh homolog 1 (Drosophila) [Mus musculus] - Gene

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Summary

Official Symbol: Dvl1provided by MGI
Official Full Name: dishevelled, dsh homolog 1 (Drosophila)provided by MGI
Primary source: MGI:94941
Locus tag: RP23-242K15.15-003
See related: Ensembl:ENSMUSG00000029071; Vega:OTTMUSG00000010890
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dvl; mKIAA4029; KIAA4029

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Genomic context

Location :: 4 E2; 4 82.0 cM

Sequence :: Chromosome: 4; NC_000070.6 (155847412..155859303)

See Dvl1 in Epigenomics, MapViewer

Chromosome 4 - NC_000070.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The antagonistic functions of Vangl2 and Dvl1 allow sharpening of planar cell polarity signaling locally on the tips of the filopodia to sense directional cues, Wnts, eventually causing turning of growth cones.
Title: Vangl2 promotes Wnt/planar cell polarity-like signaling by antagonizing Dvl1-mediated feedback inhibition in growth cone guidance.
p114-RhoGEF and Lfc are critically involved in Wnt-3a- and Dvl-induced RhoA activation and neurite retraction in N1E-115 cells.
Title: Involvement of p114-RhoGEF and Lfc in Wnt-3a- and dishevelled-induced RhoA activation and neurite retraction in N1E-115 mouse neuroblastoma cells.
TMEM88 associates with Dvl proteins and regulates Wnt signaling in a context-dependent manner
Title: Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein.
phosphorylation of Dvl triggers negative feedback regulation for different branches of Wnt signaling in a Ror2-dependent manner.
Title: Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2.
Loss of CYLD instigates tumor growth in human cylindromatosis through a mechanism in which hyperubiquitination of polymerized Dvl drives enhancement of Wnt3/beta-catenin responses.
Title: Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.
Dvl1, Dvl2 and Dvl3 are functionally redundant in cardiac outflow tract, cochlea, and neural tube development.
Title: Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development.
the C6 motif seems to reduce the interaction of Axin with Dvl-1.
Title: SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability.
G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells
Title: G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells.
The expression of Dishevelleds in mammalian cells provide an estimate of the relative cellular abundance of each Dvl.
Title: Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3.
a carboxyl-terminal binding partner, Dvl, has a role in activation of Daam1
Title: Mechanism of activation of the Formin protein Daam1.

Submit: New GeneRIF Correction See all (23)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (1) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_034221.3	NP_036177.1	Brd7	BIND	PubMed	BP75 interacts with Dvl-1. This interaction was modeled on an interaction demonstrated between human BP75 and mouse Dvl-1.
NP_034221.3	NP_034699.2	Invs	BIND	PubMed	Inv interacts with Dvl1
NP_034221.3	NP_058049.2	Smad3	BIND	PubMed	Smad3 interacts with Dvl-1. This interaction was modelled on a demonstrated interaction between human Smad3 and mouse Dvl-1.
NP_034221.3	NP_032569.1	Smad7	BIND	PubMed	Smad7 interacts with Dvl-1. This interaction was modelled on a demonstrated interaction between african clawed frog Smad7 and mouse Dvl-1.
BioGRID:199342	BioGRID:198025	Agrn	BioGRID	PubMed	Phenotypic Suppression
BioGRID:199342	BioGRID:198287	Axin1	BioGRID	PubMed	Phenotypic Suppression
BioGRID:199342	BioGRID:71396	CkIIalpha	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199342	BioGRID:205180	Csnk1e	BioGRID	PubMed	Co-localization; Phenotypic Enhancement; Phenotypic Suppression
BioGRID:199342	BioGRID:199343	Dvl2	BioGRID	PubMed	Phenotypic Enhancement; Synthetic Lethality
BioGRID:199342	BioGRID:199344	Dvl3	BioGRID	PubMed	Synthetic Lethality
BioGRID:199342	BioGRID:109187	GSK3B	BioGRID	PubMed	Phenotypic Suppression
BioGRID:199342	BioGRID:201860	Musk	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:199342	BioGRID:202020	Pak1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199342	BioGRID:222980	Prickle1	BioGRID	PubMed	Affinity Capture-Western; Phenotypic Suppression
BioGRID:199342	BioGRID:232537	Prickle2	BioGRID	PubMed	Affinity Capture-Western; Phenotypic Suppression
BioGRID:199342	BioGRID:203044	Ryk	BioGRID	PubMed	Affinity Capture-Western; Phenotypic Enhancement
BioGRID:199342	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199342	BioGRID:204580	Wnt7a	BioGRID	PubMed	Phenotypic Enhancement

Function	Evidence Code	Pubs
Rac GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
Rac GTPase binding	ISO Inferred from Sequence Orthology more info
enzyme binding	ISO Inferred from Sequence Orthology more info
frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
frizzled binding	ISO Inferred from Sequence Orthology more info
identical protein binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
protein kinase binding	ISO Inferred from Sequence Orthology more info
signal transducer activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
Wnt receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
Wnt receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
Wnt receptor signaling pathway, planar cell polarity pathway	IDA Inferred from Direct Assay more info	PubMed
Wnt receptor signaling pathway, planar cell polarity pathway	IGI Inferred from Genetic Interaction more info	PubMed
Wnt receptor signaling pathway, planar cell polarity pathway	IMP Inferred from Mutant Phenotype more info	PubMed
Wnt receptor signaling pathway, planar cell polarity pathway	ISO Inferred from Sequence Orthology more info
axon extension	IDA Inferred from Direct Assay more info	PubMed
axon guidance	IDA Inferred from Direct Assay more info	PubMed
axonogenesis	IDA Inferred from Direct Assay more info	PubMed
canonical Wnt receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
canonical Wnt receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
canonical Wnt receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
canonical Wnt receptor signaling pathway	ISO Inferred from Sequence Orthology more info
cochlea morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
collateral sprouting	IDA Inferred from Direct Assay more info	PubMed
convergent extension involved in neural plate elongation	IGI Inferred from Genetic Interaction more info	PubMed
convergent extension involved in organogenesis	IGI Inferred from Genetic Interaction more info	PubMed
convergent extension involved in organogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
cytoplasmic microtubule organization	IDA Inferred from Direct Assay more info	PubMed
cytoplasmic microtubule organization	IGI Inferred from Genetic Interaction more info	PubMed
dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
intracellular signal transduction	IEA Inferred from Electronic Annotation more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
negative regulation of protein binding	ISO Inferred from Sequence Orthology more info
negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
negative regulation of protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
neuromuscular junction development	IGI Inferred from Genetic Interaction more info	PubMed
neurotransmitter secretion	IGI Inferred from Genetic Interaction more info	PubMed
planar cell polarity pathway involved in neural tube closure	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of Wnt receptor signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of canonical Wnt receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription, DNA-dependent	IBA Inferred from Biological aspect of Ancestor more info
positive regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
prepulse inhibition	IMP Inferred from Mutant Phenotype more info	PubMed
protein localization to microtubule	IGI Inferred from Genetic Interaction more info	PubMed
protein localization to nucleus	ISO Inferred from Sequence Orthology more info
receptor clustering	IGI Inferred from Genetic Interaction more info	PubMed
regulation of neurotransmitter levels	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
skeletal muscle acetylcholine-gated channel clustering	IMP Inferred from Mutant Phenotype more info	PubMed
social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
synapse organization	IGI Inferred from Genetic Interaction more info	PubMed
synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
axon	IDA Inferred from Direct Assay more info	PubMed
axon	ISO Inferred from Sequence Orthology more info
cell	IGI Inferred from Genetic Interaction more info	PubMed
cell cortex	IBA Inferred from Biological aspect of Ancestor more info
clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoplasmic membrane-bounded vesicle	IDA Inferred from Direct Assay more info	PubMed
cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
dendrite	IBA Inferred from Biological aspect of Ancestor more info
dendrite	ISO Inferred from Sequence Orthology more info
growth cone	IBA Inferred from Biological aspect of Ancestor more info
growth cone	ISO Inferred from Sequence Orthology more info
intracellular	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
membrane fraction	NAS Non-traceable Author Statement more info	PubMed
microtubule	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with microtubule	ISO Inferred from Sequence Orthology more info
microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
microtubule cytoskeleton	ISA Inferred from Sequence Alignment more info	PubMed
neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
neuronal cell body	ISO Inferred from Sequence Orthology more info
plasma membrane	IEA Inferred from Electronic Annotation more info
soluble fraction	NAS Non-traceable Author Statement more info	PubMed
synapse	IDA Inferred from Direct Assay more info	PubMed
synaptosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: segment polarity protein dishevelled homolog DVL-1

Names: segment polarity protein dishevelled homolog DVL-1; DSH homolog 1; dishevelled-1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010091.3 → NP_034221.3 segment polarity protein dishevelled homolog DVL-1

Status: VALIDATED

Source sequence(s)

BC051991, BU702464, BY727676, U10115

Consensus CDS

CCDS19045.1

UniProtKB/Swiss-Prot

P51141

Related

ENSMUSP00000030948, OTTMUSP00000011687, ENSMUST00000030948, OTTMUST00000025523

Conserved Domains (4) summary

cd00992
Location:249 – 336
Blast Score: 179

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04438
Location:417 – 499
Blast Score: 422

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...

pfam12316
Location:604 – 685
Blast Score: 180

Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

cl02426
Location:1 – 85
Blast Score: 383

DIX; DIX domain

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000070.6 Reference GRCm38 C57BL/6J

Range

155847412..155859303

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000026.1 Alternate Mm_Celera

Range

158118352..158130254

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AL670236.9	CAM18392.1
genomic	CH466594.1	EDL15043.1	mixed
		EDL15044.1	mixed
		EDL15045.1	mixed
genomic	U28138.1	AAA74049.1	BALB/c
mRNA	AK155349.1	BAE33208.1	NOD
mRNA	AK162430.1	BAE36912.1	C57BL/6J
mRNA	AK187733.1	None
mRNA	AK220168.1	BAD90353.1
mRNA	BC018593.1	None	FVB/N
mRNA	BC051991.1	None	C57BL/6
mRNA	BC088987.1	None	C57BL/6
mRNA	BC138848.1	AAI38849.1
mRNA	BC138849.1	AAI38850.1
mRNA	BU702464.1	None	C57BL/6
mRNA	BY727676.1	None
mRNA	U10115.1	AAA82175.1	C57BL/6

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P51141.2	GenPept	UniProtKB/Swiss-Prot:P51141
Q3TRW4	GenPept	UniProtKB/TrEMBL:Q3TRW4
Q571M1	GenPept	UniProtKB/TrEMBL:Q571M1