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Drd1 dopamine receptor D1 [ Mus musculus (house mouse) ]

Gene ID: 13488, updated on 28-May-2016
Official Symbol
Drd1provided by MGI
Official Full Name
dopamine receptor D1provided by MGI
Primary source
MGI:MGI:99578
See related
Ensembl:ENSMUSG00000021478
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Drd-1; Drd1a; Gpcr15; C030036C15Rik
Orthologs
Location:
13 B1; 13 28.4 cM
Exon count:
3
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 13 NC_000079.6 (54051183..54055658, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (54146552..54151027, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130119H09 gene Neighboring gene predicted gene, 34557 Neighboring gene sideroflexin 1 Neighboring gene ribosomal protein, large, P0 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Alcoholism, organism-specific biosystem (from KEGG)
    Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • Alcoholism, conserved biosystem (from KEGG)
    Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • Amine ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Amine ligand-binding receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Amphetamine addiction, organism-specific biosystem (from KEGG)
    Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
  • Amphetamine addiction, conserved biosystem (from KEGG)
    Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Cocaine addiction, organism-specific biosystem (from KEGG)
    Cocaine addiction, organism-specific biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
  • Cocaine addiction, conserved biosystem (from KEGG)
    Cocaine addiction, conserved biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
  • Dopamine receptors, organism-specific biosystem (from REACTOME)
    Dopamine receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Dopaminergic synapse, organism-specific biosystem (from KEGG)
    Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Dopaminergic synapse, conserved biosystem (from KEGG)
    Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (s) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • Gap junction, organism-specific biosystem (from KEGG)
    Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
  • Gap junction, conserved biosystem (from KEGG)
    Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
  • Hypothetical Network for Drug Addiction, organism-specific biosystem (from WikiPathways)
    Hypothetical Network for Drug Addiction, organism-specific biosystemAdapted from figure 2 in [http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0040002 Li et al.].
  • Monoamine GPCRs, organism-specific biosystem (from WikiPathways)
    Monoamine GPCRs, organism-specific biosystem
    Monoamine GPCRs
  • Morphine addiction, organism-specific biosystem (from KEGG)
    Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Morphine addiction, conserved biosystem (from KEGG)
    Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Non-odorant GPCRs, organism-specific biosystem (from WikiPathways)
    Non-odorant GPCRs, organism-specific biosystemListing of non-odorant Mouse GCPRs by coupling.
  • Parkinson's disease, organism-specific biosystem (from KEGG)
    Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATPase binding ISO
Inferred from Sequence Orthology
more info
 
D3 dopamine receptor binding ISO
Inferred from Sequence Orthology
more info
 
G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
 
G-protein coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
G-protein coupled receptor activity ISO
Inferred from Sequence Orthology
more info
 
angiotensin receptor binding ISO
Inferred from Sequence Orthology
more info
 
dopamine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
dopamine binding ISO
Inferred from Sequence Orthology
more info
 
dopamine neurotransmitter receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
dopamine neurotransmitter receptor activity ISO
Inferred from Sequence Orthology
more info
 
dopamine neurotransmitter receptor activity, coupled via Gs IDA
Inferred from Direct Assay
more info
PubMed 
dopamine neurotransmitter receptor activity, coupled via Gs IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopamine neurotransmitter receptor activity, coupled via Gs ISO
Inferred from Sequence Orthology
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
G-protein coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger ISO
Inferred from Sequence Orthology
more info
 
activation of adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-activating G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-activating dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-activating dopamine receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
adenylate cyclase-activating dopamine receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenylate cyclase-activating dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adult walking behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
adult walking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
associative learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
associative learning ISO
Inferred from Sequence Orthology
more info
 
astrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
behavioral response to cocaine IMP
Inferred from Mutant Phenotype
more info
PubMed 
behavioral response to cocaine ISO
Inferred from Sequence Orthology
more info
 
calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
cellular response to catecholamine stimulus ISO
Inferred from Sequence Orthology
more info
 
cerebral cortex GABAergic interneuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
conditioned taste aversion IMP
Inferred from Mutant Phenotype
more info
PubMed 
dentate gyrus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopamine receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
dopamine receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
dopamine transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
feeding behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
grooming behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
habituation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hippocampus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
long term synaptic depression IMP
Inferred from Mutant Phenotype
more info
PubMed 
long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
maternal behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
mating behavior IDA
Inferred from Direct Assay
more info
PubMed 
memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of circadian sleep/wake cycle, sleep ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
neuronal action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
operant conditioning IMP
Inferred from Mutant Phenotype
more info
PubMed 
operant conditioning ISO
Inferred from Sequence Orthology
more info
 
peristalsis IGI
Inferred from Genetic Interaction
more info
PubMed 
phosphatidylinositol catabolic process ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol metabolic process ISO
Inferred from Sequence Orthology
more info
 
phospholipase C-activating dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase C-activating dopamine receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
phospholipase C-activating dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
 
positive regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT prepulse inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dopamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of ion transport ISO
Inferred from Sequence Orthology
more info
 
regulation of long-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
response to amphetamine IGI
Inferred from Genetic Interaction
more info
PubMed 
response to amphetamine IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to cocaine IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
response to drug IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensitization IGI
Inferred from Genetic Interaction
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
social behavior ISO
Inferred from Sequence Orthology
more info
 
NOT startle response IMP
Inferred from Mutant Phenotype
more info
PubMed 
striatum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic transmission, dopaminergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic transmission, dopaminergic ISO
Inferred from Sequence Orthology
more info
 
temperature homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmission of nerve impulse IMP
Inferred from Mutant Phenotype
more info
PubMed 
vasodilation IEA
Inferred from Electronic Annotation
more info
 
visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
visual learning ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
axon ISO
Inferred from Sequence Orthology
more info
 
axon terminus ISO
Inferred from Sequence Orthology
more info
 
caveola ISO
Inferred from Sequence Orthology
more info
 
ciliary membrane ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
dendritic spine head ISO
Inferred from Sequence Orthology
more info
 
dendritic spine neck ISO
Inferred from Sequence Orthology
more info
 
endomembrane system IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nonmotile primary cilium ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
D(1A) dopamine receptor
Names
D1 receptor
D1A dopamine receptor
G protein-coupled receptor DRD1
dopamine D1 receptor
dopamine receptor D1A

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291801.1NP_001278730.1  D(1A) dopamine receptor

    See identical proteins and their annotated locations for NP_001278730.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BE957273, BY298225, CT030176
    Consensus CDS
    CCDS26524.1
    UniProtKB/Swiss-Prot
    Q61616
    Conserved Domains (2) summary
    pfam00001
    Location:45331
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:40157
    7tm_4; Olfactory receptor
  2. NM_010076.3NP_034206.1  D(1A) dopamine receptor

    See identical proteins and their annotated locations for NP_034206.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK044723, BE957273, BY287823, CT030176
    Consensus CDS
    CCDS26524.1
    UniProtKB/Swiss-Prot
    Q61616
    Related
    ENSMUSP00000021932, ENSMUST00000021932
    Conserved Domains (2) summary
    pfam00001
    Location:45331
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:40157
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p3 C57BL/6J

    Range
    54051183..54055658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000035.1 Alternate Mm_Celera

    Range
    55124170..55128645 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)