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    POC5 POC5 centriolar protein homolog (Chlamydomonas) [ Homo sapiens (human) ]

    Gene ID: 134359, updated on 5-May-2013
    Official Symbol
    POC5provided by HGNC
    Official Full Name
    POC5 centriolar protein homolog (Chlamydomonas)provided by HGNC
    Primary source
    HGNC:26658
    See related
    Ensembl:ENSG00000152359; HPRD:08188; Vega:OTTHUMG00000162487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C5orf37
    Location :
    5q13.3
    Sequence :
    Chromosome: 5; NC_000005.9 (74970023..75013313, complement)
    See POC5 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene collagen, type IV, alpha 3 (Goodpasture antigen) binding protein Neighboring gene polymerase (DNA directed) kappa Neighboring gene ankyrin repeat and death domain containing 1B Neighboring gene solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 pseudogene 9 Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, et al. Nat Cell Biol, 2012 Oct. PMID 23000965.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Speliotes EK, et al. Nat Genet, 2010 Nov. PMID 20935630.
    4. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068.
    5. hPOC5 is a centrin-binding protein required for assembly of full-length centrioles. Azimzadeh J, et al. J Cell Biol, 2009 Apr 6. PMID 19349582.

    See all (9) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. hPOC5, a conserved centrin-binding protein that contains Sfi1p-like repeats is characterized.
      Title: hPOC5 is a centrin-binding protein required for assembly of full-length centrioles.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:126396 BioGRID:204930 Cetn2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:126396 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    Markers

    Genotypes

    Homology

    Clone Names

    • FLJ35779, MGC120442, MGC120443, MGC120444

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    centrosome IDA
    Inferred from Direct Assay
    more info
    		  
    Preferred Names
    centrosomal protein POC5
    Names
    centrosomal protein POC5
    hPOC5
    protein of centriole 5
    proteome of centriole 5

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099271.1 → NP_001092741.1  centrosomal protein POC5 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC010695, BJ991592, CA441610
      Consensus CDS
      CCDS47236.1
      UniProtKB/Swiss-Prot
      Q8NA72
      Related
      ENSP00000410216, OTTHUMP00000222114, ENST00000428202, OTTHUMT00000369124

    2. NM_152408.2 → NP_689621.2  centrosomal protein POC5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the presence and absence of exons at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a unique start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      BC101327, CA441610, DB448626
      Consensus CDS
      CCDS47237.1
      UniProtKB/Swiss-Prot
      Q8NA72
      Related
      ENSP00000399481, OTTHUMP00000222115, ENST00000446329, OTTHUMT00000369126

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p10 Primary Assembly

      Range
      74970023..75013313, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      70175062..70218349, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018916.1 Alternate CHM1_1.0

      Range
      75263097..75306383, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01061946.1 (30909..74196) None
    genomic AC010245.4 (108680..117840) None
    genomic AC025170.6 (8277..37110) None
    genomic AMYH01015411.1 (25915..69201) None
    genomic CH471084.1 EAW95767.1
      EAW95768.1
      EAW95769.1
    mRNA AK093098.1 BAC04054.1
    mRNA AK296071.1 BAG58829.1
    mRNA AK311296.1 None
    mRNA BC010695.1 None
    mRNA BC050459.1 None
    mRNA BC065750.1 AAH65750.1
    mRNA BC101325.1 AAI01326.1
    mRNA BC101326.2 AAI01327.1
    mRNA BC101327.2 AAI01328.1
    mRNA BC101328.2 None
    mRNA BJ991592.1 None
    mRNA CA441610.1 None
    mRNA DB448626.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NA72.2 GenPept UniProtKB/Swiss-Prot:Q8NA72

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

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