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Dnm1 dynamin 1 [ Mus musculus (house mouse) ]

Gene ID: 13429, updated on 8-May-2016
Official Symbol
Dnm1provided by MGI
Official Full Name
dynamin 1provided by MGI
Primary source
MGI:MGI:107384
See related
Ensembl:ENSMUSG00000026825 Vega:OTTMUSG00000012945
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dnm; Ftfl; AI838169; mKIAA4093
Summary
This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein is a GTPase which is required for membrane recycling, including vesicle endocytosis in neurons. It may also be involved in cellular fission via association with microtubules and actin filaments. Mutations in this gene have been shown to cause seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Orthologs
Location:
2 B; 2 22.09 cM
Exon count:
27
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (32308471..32353339, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (32163991..32208824, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene SWI5 recombination repair homolog (yeast) Neighboring gene golgi autoantigen, golgin subfamily a, 2 Neighboring gene predicted gene, 23363 Neighboring gene microRNA 199b Neighboring gene predicted gene, 39787 Neighboring gene CDKN1A interacting zinc finger protein 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA4093

Gene Ontology Provided by MGI

Function Evidence Code Pubs
D2 dopamine receptor binding ISO
Inferred from Sequence Orthology
more info
 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
nitric-oxide synthase binding ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
protein dimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor internalization ISO
Inferred from Sequence Orthology
more info
 
adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
clathrin-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
endocytosis ISO
Inferred from Sequence Orthology
more info
 
endosome organization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic vesicle recycling ISO
Inferred from Sequence Orthology
more info
 
protein tetramerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
receptor internalization ISO
Inferred from Sequence Orthology
more info
 
receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
toxin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
membrane coat IDA
Inferred from Direct Assay
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
photoreceptor inner segment IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
varicosity ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
dynamin-1
NP_001288666.1
NP_034195.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301737.1NP_001288666.1  dynamin-1 isoform 2

    See identical proteins and their annotated locations for NP_001288666.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. This variant contains the alternate "a" exon in the central coding region and the "b" splicing pattern in the 3' coding region (PMID:10398046, PMID:20700442).
    Source sequence(s)
    AK011651, AL808027, BC034679, BQ179370, BY297150, CA328097, CO425806
    Consensus CDS
    CCDS79772.1
    UniProtKB/Swiss-Prot
    P39053
    Related
    ENSMUSP00000077461, OTTMUSP00000013921, ENSMUST00000078352, OTTMUST00000031101
    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  2. NM_010065.3NP_034195.2  dynamin-1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). This variant contains the alternate "b" exon in the central coding region and the "a" splicing pattern in the 3' coding region (PMID:10398046, PMID:20700442).
    Source sequence(s)
    AA387428, AI894003, AK011651, BC058623, BE860433, BM950315, BY297150, CX239206
    Consensus CDS
    CCDS38102.1
    UniProtKB/Swiss-Prot
    P39053
    Related
    ENSMUSP00000088618, OTTMUSP00000013923, ENSMUST00000091089, OTTMUST00000031103
    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78600
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:652741
    GED; Dynamin GTPase effector domain
    cd01256
    Location:514625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain

RNA

  1. NR_125959.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains two alternate exons in the central region and uses an alternate splice site in the 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This variant contains the alternate "b" exon in the central region (PMID:20700442).
    Source sequence(s)
    BC034679, BY297150
    Related
    ENSMUST00000139624, OTTMUST00000031099

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    32308471..32353339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497653.2XP_006497716.2  

    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78600
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:652741
    GED; Dynamin GTPase effector domain
    cd01256
    Location:514625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  2. XM_006497651.2XP_006497714.2  

    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  3. XM_006497649.2XP_006497712.2  

    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  4. XM_006497655.2XP_006497718.2  

    UniProtKB/Swiss-Prot
    P39053
    Related
    ENSMUSP00000108992, OTTMUSP00000013924, ENSMUST00000113365, OTTMUST00000031104
    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  5. XM_006497650.2XP_006497713.2  

    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  6. XM_006497661.2XP_006497724.2  

    UniProtKB/Swiss-Prot
    P39053
    Related
    ENSMUSP00000108977, OTTMUSP00000013922, ENSMUST00000113350, OTTMUST00000031102
    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  7. XM_006497654.2XP_006497717.2  

    See identical proteins and their annotated locations for XP_006497717.2

    UniProtKB/TrEMBL
    A0A0J9YUN4
    Related
    ENSMUSP00000144264, OTTMUSP00000072916, ENSMUST00000201433, OTTMUST00000138772
    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  8. XM_006497662.2XP_006497725.1  

    Conserved Domains (5) summary
    cd08771
    Location:100340
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:124650
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:262533
    Dynamin_M; Dynamin central region
    pfam02212
    Location:702791
    GED; Dynamin GTPase effector domain
    cd01256
    Location:566675
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  9. XM_006497658.2XP_006497721.2  

    See identical proteins and their annotated locations for XP_006497721.2

    UniProtKB/Swiss-Prot
    P39053
    Related
    ENSMUSP00000143955, OTTMUSP00000072918, ENSMUST00000202578, OTTMUST00000138774
    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  10. XM_006497659.2XP_006497722.2  

    See identical proteins and their annotated locations for XP_006497722.2

    UniProtKB/Swiss-Prot
    P39053
    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  11. XM_006497652.2XP_006497715.2  

    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  12. XM_006497660.2XP_006497723.2  

    See identical proteins and their annotated locations for XP_006497723.2

    UniProtKB/Swiss-Prot
    P39053
    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain

RNA

  1. XR_374055.2 RNA Sequence

  2. XR_374058.2 RNA Sequence

  3. XR_374057.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    32012962..32058555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)