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Dync1i2 dynein cytoplasmic 1 intermediate chain 2 [ Mus musculus (house mouse) ]

Gene ID: 13427, updated on 8-May-2016
Official Symbol
Dync1i2provided by MGI
Official Full Name
dynein cytoplasmic 1 intermediate chain 2provided by MGI
Primary source
MGI:MGI:107750
See related
Ensembl:ENSMUSG00000027012 Vega:OTTMUSG00000013157
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dncic2; AW554389; 3110079H08Rik
Orthologs
Location:
2 C2; 2 42.38 cM
Exon count:
21
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (71211706..71263303)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (71050070..71101351)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene cytochrome b reductase 1 Neighboring gene predicted gene, 39576 Neighboring gene solute carrier family 25 (mitochondrial carrier, Aralar), member 12 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene histone aminotransferase 1 Neighboring gene nuclear protein-NHP2-like protein pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Chemically induced (ENU) (1) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
motor activity IEA
Inferred from Electronic Annotation
more info
 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
microtubule-based movement IEA
Inferred from Electronic Annotation
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic dynein complex IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
dynein complex IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
cytoplasmic dynein 1 intermediate chain 2
Names
DH IC-2
cytoplasmic dynein intermediate chain 2 isoform 2.1
cytoplasmic dynein intermediate chain 2 isoform 2.2
cytoplasmic dynein intermediate chain 2 isoform 2.5
dynein intermediate chain 2, cytosolic
dynein, cytoplasmic, intermediate chain 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198872.1NP_001185801.1  cytoplasmic dynein 1 intermediate chain 2 isoform 1

    See identical proteins and their annotated locations for NP_001185801.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1; also called 1a.D) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 6 encode the same protein.
    Source sequence(s)
    BQ174310, BY065048, GU992208
    UniProtKB/TrEMBL
    D6Q0F5
    Conserved Domains (3) summary
    pfam11540
    Location:149181
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    COG2319
    Location:346616
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:397622
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001198873.1NP_001185802.1  cytoplasmic dynein 1 intermediate chain 2 isoform 2

    See identical proteins and their annotated locations for NP_001185802.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2; also called 1a.E) uses an alternate splice acceptor site in the 5' coding region, compared to variant 1. Variant 2 encodes a shorter isoform (2), compared to isoform 1. Variants 2 and 7 encode the same protein.
    Source sequence(s)
    BQ174310, BY065048, GU992209
    UniProtKB/TrEMBL
    D6Q0F6
    Conserved Domains (3) summary
    pfam11540
    Location:144176
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    COG2319
    Location:341611
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:392617
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001198874.1NP_001185803.1  cytoplasmic dynein 1 intermediate chain 2 isoform 3

    See identical proteins and their annotated locations for NP_001185803.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3; also called 1a.B) lacks multiple exons in the 5' coding region, compared to variant 1. Variant 3 encodes a shorter isoform (3), compared to isoform 1.
    Source sequence(s)
    AK141837, BQ174310, BY065048
    Consensus CDS
    CCDS57175.1
    UniProtKB/TrEMBL
    Q3TPJ8
    Related
    ENSMUSP00000107770, OTTMUSP00000018985, ENSMUST00000112142, OTTMUST00000031847
    Conserved Domains (3) summary
    pfam11540
    Location:126158
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    COG2319
    Location:323593
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:374599
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_001198875.1NP_001185804.1  cytoplasmic dynein 1 intermediate chain 2 isoform 4

    See identical proteins and their annotated locations for NP_001185804.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4; also called 1a.F) lacks multiple exons in the 5' coding region, compared to variant 1. Variant 4 encodes a shorter isoform (4), compared to isoform 1.
    Source sequence(s)
    BQ174310, BY065048, GU992210
    UniProtKB/TrEMBL
    D6Q0F7
    Conserved Domains (3) summary
    pfam11540
    Location:112144
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    COG2319
    Location:309579
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:256578
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. NM_001198876.1NP_001185805.1  cytoplasmic dynein 1 intermediate chain 2 isoform 5

    See identical proteins and their annotated locations for NP_001185805.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5; also called 1a.C) lacks multiple exons in the 5' coding region, compared to variant 1. Variant 5 encodes a shorter isoform (5), compared to isoform 1. Variants 5 and 8 encode the same protein.
    Source sequence(s)
    AK164437, BQ174310, BY065048
    Consensus CDS
    CCDS16112.1
    UniProtKB/Swiss-Prot
    O88487
    UniProtKB/TrEMBL
    A2BFF7
    Related
    ENSMUSP00000107766, OTTMUSP00000018980, ENSMUST00000112138, OTTMUST00000042239
    Conserved Domains (3) summary
    pfam11540
    Location:106138
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    COG2319
    Location:303573
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:253572
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. NM_001198877.1NP_001185806.1  cytoplasmic dynein 1 intermediate chain 2 isoform 1

    See identical proteins and their annotated locations for NP_001185806.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6; also called 1b.D) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 6 encode the same protein (isoform 1).
    Source sequence(s)
    AK168730, BQ174310, BY226221, GU992211
    UniProtKB/Swiss-Prot
    O88487
    UniProtKB/TrEMBL
    D6Q0F5
    Conserved Domains (3) summary
    pfam11540
    Location:149181
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    COG2319
    Location:346616
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:397622
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. NM_001198878.1NP_001185807.1  cytoplasmic dynein 1 intermediate chain 2 isoform 2

    See identical proteins and their annotated locations for NP_001185807.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7; also called 1b.E) differs in the 5' UTR and uses an alternate splice acceptor site in the 5' coding region, compared to variant 1. Variant 7 encodes a shorter isoform (2), compared to isoform 1. Variants 2 and 7 encode the same protein.
    Source sequence(s)
    AK164437, BQ174310, BY226221, GU992212
    UniProtKB/Swiss-Prot
    O88487
    UniProtKB/TrEMBL
    D6Q0F6
    Conserved Domains (3) summary
    pfam11540
    Location:144176
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    COG2319
    Location:341611
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:392617
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  8. NM_010064.4NP_034194.1  cytoplasmic dynein 1 intermediate chain 2 isoform 5

    See identical proteins and their annotated locations for NP_034194.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8; also called 1b.C) differs in the 5' UTR and lacks multiple exons in the 5' coding region, compared to variant 1. Variant 8 encodes a shorter isoform (5), compared to isoform 1. Variants 5 and 8 encode the same protein.
    Source sequence(s)
    AK168730, BQ174310, BY226221, GU992210
    Consensus CDS
    CCDS16112.1
    UniProtKB/Swiss-Prot
    O88487
    UniProtKB/TrEMBL
    A2BFF7, D6Q0F7
    Related
    ENSMUSP00000080410, OTTMUSP00000014162, ENSMUST00000081710, OTTMUST00000031778
    Conserved Domains (3) summary
    pfam11540
    Location:106138
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    COG2319
    Location:303573
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:253572
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    71211706..71263303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498674.1XP_006498737.1  

    UniProtKB/TrEMBL
    A2BFF9
    Related
    ENSMUSP00000107772, OTTMUSP00000018983, ENSMUST00000112144, OTTMUST00000042242
    Conserved Domains (3) summary
    pfam11540
    Location:132164
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    COG2319
    Location:329599
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:380605
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_006498676.1XP_006498739.1  

    UniProtKB/TrEMBL
    A2BFF5
    Related
    ENSMUSP00000107764, OTTMUSP00000018984, ENSMUST00000112136, OTTMUST00000042243
    Conserved Domains (3) summary
    pfam11540
    Location:132164
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    COG2319
    Location:329599
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:279598
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_006498678.1XP_006498741.1  

    See identical proteins and their annotated locations for XP_006498741.1

    UniProtKB/TrEMBL
    D6Q0F7
    Conserved Domains (3) summary
    pfam11540
    Location:112144
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    COG2319
    Location:309579
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:256578
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_006498677.1XP_006498740.1  

    See identical proteins and their annotated locations for XP_006498740.1

    UniProtKB/TrEMBL
    Q3TPJ8
    Related
    ENSMUSP00000097605, OTTMUSP00000014189, ENSMUST00000100028, OTTMUST00000031846
    Conserved Domains (3) summary
    pfam11540
    Location:126158
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    COG2319
    Location:323593
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:374599
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_006498681.1XP_006498744.1  

    Conserved Domains (3) summary
    pfam11540
    Location:126158
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    COG2319
    Location:323593
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:273592
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. XM_006498679.1XP_006498742.1  

    UniProtKB/TrEMBL
    A2BFF8
    Related
    ENSMUSP00000107767, OTTMUSP00000018981, ENSMUST00000112139, OTTMUST00000042240
    Conserved Domains (3) summary
    pfam11540
    Location:106138
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    COG2319
    Location:303573
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:253572
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. XM_006498680.2XP_006498743.1  

    Conserved Domains (3) summary
    pfam11540
    Location:132164
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    COG2319
    Location:281512
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:282509
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    72870427..72922173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)