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    Dync1i1 dynein cytoplasmic 1 intermediate chain 1 [ Mus musculus (house mouse) ]

    Gene ID: 13426, updated on 15-Jun-2013
    Official Symbol
    Dync1i1provided by MGI
    Official Full Name
    dynein cytoplasmic 1 intermediate chain 1provided by MGI
    Primary source
    MGI:107743
    See related
    Ensembl:ENSMUSG00000029757; Vega:OTTMUSG00000023538
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DIC; IC74; DHIC-1; Dncic1; DH IC-1
    Location :
    6 A1; 6 2.26 cM
    Sequence :
    Chromosome: 6; NC_000072.6 (5725639..6028039)
    See Dync1i1 in Epigenomics, MapViewer

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 4 Neighboring gene pyruvate dehydrogenase kinase, isoenzyme 4 Neighboring gene RIKEN cDNA 1700019G24 gene Neighboring gene solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13 Neighboring gene uncharacterized LOC101056138

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Functional characterization of tissue-specific enhancers in the DLX5/6 locus. Birnbaum RY, et al. Hum Mol Genet, 2012 Nov 15. PMID 22914741.
    2. Coding exons function as tissue-specific enhancers of nearby genes. Birnbaum RY, et al. Genome Res, 2012 Jun. PMID 22442009.
    3. A Cdk5-dependent switch regulates Lis1/Ndel1/dynein-driven organelle transport in adult axons. Pandey JP, et al. J Neurosci, 2011 Nov 23. PMID 22114287.
    4. LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1. Ye S, et al. PLoS One, 2011. PMID 22073305.
    5. Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases. Van Campenhout CA, et al. Dev Cell, 2011 Sep 13. PMID 21920314.

    See all (43) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. results indicate that LIS1 is a previously unrecognized regulator of osteoclast formation, microtubule organization, and lysosomal secretion by virtue of its ability to modulate dynein function and Plekhm1
      Title: LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1.
    2. An all-atom model structure is obtained for dynein high-affinity form of microtubule (MT) binding domain bound to MT by an anisotropic network model, protein-protein docking, and molecular dynamics simulation
      Title: How does a registry change in dynein's coiled-coil stalk drive binding of dynein to microtubules?
    3. These results demonstrate the important role that dynein-controlled processes play in the correct development and function of the mammalian nervous system.
      Title: Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse.
    4. Study found six different Dync1i1 splicing pattern in mice.
      Title: Mouse cytoplasmic dynein intermediate chains: identification of new isoforms, alternative splicing and tissue distribution of transcripts.
    Submit: New GeneRIF Correction
    Products Interactant Other Gene Complex Source Pubs Description
    NP_034193.1 NP_032491.2 Kpna1    BIND  PubMed Dncic1 (Dyn) interacts with Kpna1 (Imp-Alpha). 
    NP_034193.1 NP_032405.2 Kpnb1    BIND  PubMed Dncic1 (Dyn) interacts with Kpnb1 (Imp-Beta). 
    NP_034193.1 NP_036079.1 Mapk1    BIND  PubMed Dncic1 (Dyn) interacts with Mapk1 (Erk2). 
    NP_034193.1 NP_036082.1 Mapk3    BIND  PubMed Dncic1 (Dyn) interacts with Mapk3 (Erk1). 
    NP_034193.1 NP_035831.2 Vim    BIND  PubMed Dncic1 (Dyn) interacts with Vim. 
    BioGRID:199255 BioGRID:114206 DYNLL1    BioGRID  PubMed Co-fractionation 
    BioGRID:199255 BioGRID:207274 Dlg3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:199255 BioGRID:199254 Dync1h1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:199255 BioGRID:158560 GNB1    BioGRID  PubMed Two-hybrid 
    BioGRID:199255 BioGRID:199976 Gnb1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:199255 BioGRID:212013 Nde1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:199255 BioGRID:206130 Slc25a13    BioGRID  PubMed Affinity Capture-Western 
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
      MHC class II antigen presentation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Salmonella infection, organism-specific biosystem (from KEGG)
      Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Salmonella infection, conserved biosystem (from KEGG)
      Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Vasopressin-regulated water reabsorption, organism-specific biosystem (from KEGG)
      Vasopressin-regulated water reabsorption, organism-specific biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...
    • Vasopressin-regulated water reabsorption, conserved biosystem (from KEGG)
      Vasopressin-regulated water reabsorption, conserved biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    microtubule motor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    vesicle transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasmic dynein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    dynein complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Preferred Names
    cytoplasmic dynein 1 intermediate chain 1
    Names
    cytoplasmic dynein 1 intermediate chain 1
    dynein, cytoplasmic, intermediate chain 1
    cytoplasmic dynein intermediate chain 1 isoform 1.6
    Dynein intermediate chain 1, cytosolic (DH IC-1) (Cytoplasmic dynein intermediate chain 1)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191023.1 → NP_001177952.1  cytoplasmic dynein 1 intermediate chain 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and lacks a coding exon compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC023175, AC034254, BC051992, GU992206
      UniProtKB/TrEMBL
      D6Q0F3
      UniProtKB/Swiss-Prot
      O88485
      Conserved Domains (3) summary
      COG2319
      Location:177 – 595
      Blast Score: 178
      COG2319; FOG: WD40 repeat [General function prediction only]
      pfam11540
      Location:122 – 153
      Blast Score: 148
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
      cl02567
      Location:263 – 586
      Blast Score: 202
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001191025.1 → NP_001177954.1  cytoplasmic dynein 1 intermediate chain 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: Transcript Variant: This variant (4) lacks an exon in the 5' coding region compared to variant 1. The resulting protein (isoform 4) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC023175, AC034254, BC051992
      Consensus CDS
      CCDS57408.1
      UniProtKB/Swiss-Prot
      O88485
      Related
      ENSMUSP00000111216, OTTMUSP00000027678, ENSMUST00000115554, OTTMUST00000057389
      Conserved Domains (3) summary
      COG2319
      Location:160 – 578
      Blast Score: 178
      COG2319; FOG: WD40 repeat [General function prediction only]
      pfam11540
      Location:105 – 136
      Blast Score: 148
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
      cl02567
      Location:246 – 569
      Blast Score: 204
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001191026.1 → NP_001177955.1  cytoplasmic dynein 1 intermediate chain 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC023175, AC034254, AK158589
      Consensus CDS
      CCDS57409.1
      UniProtKB/TrEMBL
      Q3TYJ3
      Related
      ENSMUSP00000111218, OTTMUSP00000027675, ENSMUST00000115556, OTTMUST00000057386
      Conserved Domains (3) summary
      COG2319
      Location:169 – 587
      Blast Score: 173
      COG2319; FOG: WD40 repeat [General function prediction only]
      pfam11540
      Location:114 – 145
      Blast Score: 150
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
      cl02567
      Location:255 – 578
      Blast Score: 202
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. NM_001191027.1 → NP_001177956.1  cytoplasmic dynein 1 intermediate chain 1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region and lacks a coding exon compared to variant 1. The resulting protein (isoform 5) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC023175, AC034254, GU992207
      UniProtKB/TrEMBL
      D6Q0F4
      Conserved Domains (3) summary
      COG2319
      Location:149 – 567
      Blast Score: 176
      COG2319; FOG: WD40 repeat [General function prediction only]
      pfam11540
      Location:94 – 125
      Blast Score: 147
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
      cl02567
      Location:235 – 558
      Blast Score: 204
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. NM_010063.4 → NP_034193.2  cytoplasmic dynein 1 intermediate chain 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC023175, AC034254, BC051992
      Consensus CDS
      CCDS19903.1
      UniProtKB/Swiss-Prot
      O88485
      Related
      ENSMUSP00000111221, OTTMUSP00000027677, ENSMUST00000115559, OTTMUST00000057388
      Conserved Domains (3) summary
      COG2319
      Location:180 – 598
      Blast Score: 175
      COG2319; FOG: WD40 repeat [General function prediction only]
      pfam11540
      Location:125 – 156
      Blast Score: 150
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
      cl02567
      Location:266 – 589
      Blast Score: 202
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p1 C57BL/6J

      Range
      5725639..6028039
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000028.1 Alternate Mm_Celera

      Range
      5874647..6178900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01051147.1 None
    genomic AAHY01051148.1 None
    genomic AAHY01051149.1 None
    genomic AAHY01051150.1 None
    genomic AAHY01051151.1 None
    genomic AAHY01051152.1 None
    genomic AAHY01051153.1 None
    genomic AAHY01051154.1 None
    genomic AAHY01051155.1 (98276..147302) None
    genomic AC023175.4 (46773..118930) None C57BL/6J
    genomic AC023286.4 (66926..190251) None C57BL/6J
    genomic AC034254.4 (84081..116022) None C57BL/6J
    genomic AC162178.2 (113087..188061) None
    genomic CH466533.2 EDL13959.1 mixed
      EDL13960.1 mixed
    mRNA AF063229.1 AAC33444.1
    mRNA AF063230.1 AAC33445.1
    mRNA AK158589.1 BAE34570.1 C57BL/6J
    mRNA BC051992.1 AAH51992.1 C57BL/6
    mRNA BY238976.1 None C57BL/6J
    mRNA GU992206.1 ADF57193.1 C57BL/6J
    mRNA GU992207.1 ADF57194.1 C57BL/6J
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88485.2 GenPept UniProtKB/Swiss-Prot:O88485

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
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        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
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      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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