Dll1 delta-like 1 (Drosophila) [Mus musculus] - Gene

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Summary

Official Symbol: Dll1provided by MGI
Official Full Name: delta-like 1 (Drosophila)provided by MGI
Primary source: MGI:104659
See related: Ensembl:ENSMUSG00000014773; Vega:OTTMUSG00000021037
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Delta1

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Genomic context

Location :: 17 A2; 17 8.2 cM

Sequence :: Chromosome: 17; NC_000083.6 (15367354..15375823, complement)

See Dll1 in Epigenomics, MapViewer

Chromosome 17 - NC_000083.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest that Notch signaling through macrophage-dependent Dll1 is critical in providing an anti-viral response during influenza infection by linking innate and acquired immunity
Title: The critical role of Notch ligand Delta-like 1 in the pathogenesis of influenza A virus (H1N1) infection.
the presence of Gal on O-fucose glycans differentially affects DLL1-induced NOTCH signaling modulated by LFNG versus MFNG
Title: Galactose differentially modulates lunatic and manic fringe effects on Delta1-induced NOTCH signaling.
Dll1 acts as an extrinsic cue involved in tip cell selection, which directs vessel sprouting and branch formation.
Title: Extrinsic Notch ligand Delta-like 1 regulates tip cell selection and vascular branching morphogenesis.
Data find that only secretory cells pass through a phase of strong expression of the Notch ligand Delta1. Onset of this Dll1 expression coincides with a block to further cell division and is followed by expression of Neurog3 or Gfi1.
Title: Delta1 expression, cell cycle exit, and commitment to a specific secretory fate coincide within a few hours in the mouse intestinal stem cell system.
Ptf1a-induced Dll1 expression stimulates multipotent pancreatic progenitor cells proliferation and pancreatic growth by maintaining Hes1 expression and Ptf1a protein levels.
Title: Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism.
Anti-delta1 monoclonal antibody-treated heart transplants are a potential target in this study to improve graft-prolonging effects of Notch ligand delta1.
Title: Blockade of Notch ligand δ1 promotes allograft survival by inhibiting alloreactive Th1 cells and cytotoxic T cell generation.
Dll1 can promote the differentiation of DCs from mouse bone marrow cells and enhance their antigen presentation capacity.
Title: [Role of Delta-like 1 in differentiation and antigen presentation of mouse bone marrow-derived dendritic cells].
overexpression of Dll1 could activate Notch signaling in tumor cells, and promote tumor cell proliferation in vitro
Title: Overexpression of Notch ligand Dll1 in B16 melanoma cells leads to reduced tumor growth due to attenuated vascularization.
Elav-like (Elavl1)/HuR becomes enriched in the cytoplasm of neuroepithelial cells undergoing mitosis and that this ribonucleoprotein binds the 3' untranslated region (UTR) of Dll1 mRNA and stabilizes it.
Title: Stabilization of Dll1 mRNA by Elavl1/HuR in neuroepithelial cells undergoing mitosis.
These data suggest that MT1-MMP directly cleaves Dll1 on bone marrow stromal cells to negatively regulate Notch signalling to specifically maintain normal B-cell development in bone marrow.
Title: MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development.

Submit: New GeneRIF Correction See all (59)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (Reporter) (1) 1 citation
Chemically induced (ENU) (2) 1 citation
Targeted (knock-in) (1) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_031891.2	NP_034497.1	Magi1	BIND	PubMed	Delta1 interacts with MAGI-1. This interaction was modeled on a demonstrated interaction between human Delta1 and mouse MAGI-1.
NP_031891.2	NP_056638.1	Magi2	BIND	PubMed	Delta1 interacts with MAGI-2. This interaction was modeled on a demonstrated interaction between human Delta1 and mouse MAGI-2.
NP_031891.2	NP_598614.1	Magi3	BIND	PubMed	Delta1 interacts with MAGI-3. This interaction was modeled on a demonstrated interaction between human Delta1 and mouse MAGI-3.
NP_031891.2	NP_056591.1	Mfap5	BIND	PubMed	Mfap5 (MAGP-2) interacts with Dll1 (Delta1).
NP_031891.2	NP_034950.1	Mpdz	BIND	PubMed	Delta1 interacts with MUPP1. This interaction was modeled on a demonstrated interaction between human Delta1 and mouse MUPP1.
BioGRID:199232	BioGRID:240592	Neurl2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199232	BioGRID:201808	Notch1	BioGRID	PubMed	Reconstituted Complex
BioGRID:199232	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex

Function	Evidence Code	Pubs
Notch binding	IPI Inferred from Physical Interaction more info	PubMed
Notch binding	ISO Inferred from Sequence Orthology more info
calcium ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
Notch signaling pathway	ISO Inferred from Sequence Orthology more info
Notch signaling pathway	TAS Traceable Author Statement more info	PubMed
auditory receptor cell differentiation	NAS Non-traceable Author Statement more info	PubMed
auditory receptor cell fate commitment	NAS Non-traceable Author Statement more info	PubMed
cell communication	IEA Inferred from Electronic Annotation more info
cell differentiation	IEA Inferred from Electronic Annotation more info
cell-cell signaling	IDA Inferred from Direct Assay more info	PubMed
compartment pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
in utero embryonic development	NAS Non-traceable Author Statement more info	PubMed
inner ear development	IMP Inferred from Mutant Phenotype more info	PubMed
inner ear morphogenesis	NAS Non-traceable Author Statement more info	PubMed
multicellular organismal development	IEA Inferred from Electronic Annotation more info
negative regulation of auditory receptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of myeloid cell differentiation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info
nervous system development	NAS Non-traceable Author Statement more info	PubMed
odontogenesis of dentin-containing tooth	NAS Non-traceable Author Statement more info	PubMed
organ morphogenesis	NAS Non-traceable Author Statement more info	PubMed
positive regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
somite specification	IMP Inferred from Mutant Phenotype more info	PubMed
somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: delta-like protein 1

Names: delta-like protein 1; delta like-1; drosophila Delta homolog 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007865.3 → NP_031891.2 delta-like protein 1 precursor

Status: VALIDATED

Source sequence(s)

BC065063, BQ768900

Consensus CDS

CCDS37452.1

UniProtKB/Swiss-Prot

Q61483

Related

ENSMUSP00000014917, OTTMUSP00000023104, ENSMUST00000014917, OTTMUST00000049746

Conserved Domains (4) summary

cd00054
Location:287 – 325
Blast Score: 110

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07657
Location:21 – 94
Blast Score: 303

MNNL; N terminus of Notch ligand

pfam01414
Location:158 – 220
Blast Score: 272

DSL; Delta serrate ligand

cl09941
Location:485 – 514
Blast Score: 80

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000083.6 Reference GRCm38 C57BL/6J

Range

15367354..15375823, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000039.1 Alternate Mm_Celera

Range

16154981..16163462, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC154378.2 (47306..55539)	None
genomic	AY497019.1	AAR30869.1	C57BL/6J
genomic	CH466630.2	EDL20466.1	mixed
mRNA	BC057400.1	AAH57400.1	C57BL/6
mRNA	BC065063.1	AAH65063.1	C57BL/6
mRNA	BQ768900.1	None	C57BL/6
mRNA	X80903.1	CAA56865.1	BALB/c x C57BL/6