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UGT3A1 UDP glycosyltransferase family 3 member A1 [ Homo sapiens (human) ]

Gene ID: 133688, updated on 26-May-2016
Official Symbol
UGT3A1provided by HGNC
Official Full Name
UDP glycosyltransferase family 3 member A1provided by HGNC
Primary source
HGNC:HGNC:26625
See related
Ensembl:ENSG00000145626 HPRD:08175; MIM:616383; Vega:OTTHUMG00000131107
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Orthologs
Location:
5p13.2
Exon count:
11
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (35953089..36001045, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (35953191..36066639, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene calcyphosine like Neighboring gene uncharacterized LOC100506406 Neighboring gene UDP glycosyltransferase family 3 member A2 Neighboring gene LMBR1 domain containing 2 Neighboring gene microRNA 580

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ26528, FLJ34658

Gene Ontology Provided by GOA

Function Evidence Code Pubs
UDP-glycosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
flavonoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
flavonoid glucuronidation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
UDP-N-acetylglucosamine transferase complex IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
UDP-glucuronosyltransferase 3A1
Names
UDP glycosyltransferase 3 family, polypeptide A1
UDPGT 3A1
NP_001165344.1
NP_689617.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171873.1NP_001165344.1  UDP-glucuronosyltransferase 3A1 isoform 2

    See identical proteins and their annotated locations for NP_001165344.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences, compared to variant 1. These differences result in distinct 5' UTR and 3' UTRs, cause translation initiation at a downstream start codon and result in a frameshift and an early stop codon, compared to variant 1. The encoded isoform has a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC016612, BC035012
    Consensus CDS
    CCDS54841.1
    UniProtKB/Swiss-Prot
    Q6NUS8
    UniProtKB/TrEMBL
    A0A024R085
    Related
    ENSP00000487376, OTTHUMP00000278403, ENST00000625798, OTTHUMT00000480816
    Conserved Domains (1) summary
    pfam00201
    Location:26227
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
  2. NM_152404.3NP_689617.3  UDP-glucuronosyltransferase 3A1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_689617.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC112204, AI244517, AK296136, AK315851
    Consensus CDS
    CCDS3913.1
    UniProtKB/Swiss-Prot
    Q6NUS8
    UniProtKB/TrEMBL
    A8K444, B7Z3N0
    Related
    ENSP00000274278, OTTHUMP00000161735, ENST00000274278, OTTHUMT00000253770
    Conserved Domains (3) summary
    cd03784
    Location:129436
    GT1_Gtf_like; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the ...
    pfam00201
    Location:23505
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
    cl00438
    Location:2558
    FMN_red; NADPH-dependent FMN reductase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    35953089..36001045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513959.1XP_011512261.1  

    See identical proteins and their annotated locations for XP_011512261.1

    Conserved Domains (2) summary
    cd03784
    Location:75382
    GT1_Gtf_like; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the ...
    COG1819
    Location:23415
    YjiC; UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism]
  2. XM_011513961.1XP_011512263.1  

    Conserved Domains (1) summary
    cl10013
    Location:16323
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
  3. XM_011513957.1XP_011512259.1  

    Conserved Domains (2) summary
    cd03784
    Location:98405
    GT1_Gtf_like; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the ...
    COG1819
    Location:46438
    YjiC; UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism]
  4. XM_011513956.1XP_011512258.1  

    Conserved Domains (2) summary
    cd03784
    Location:132439
    GT1_Gtf_like; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the ...
    pfam00201
    Location:36508
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
  5. XM_011513960.1XP_011512262.1  

    See identical proteins and their annotated locations for XP_011512262.1

    Conserved Domains (2) summary
    cd03784
    Location:75382
    GT1_Gtf_like; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the ...
    COG1819
    Location:23415
    YjiC; UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism]
  6. XM_006714441.2XP_006714504.1  

    See identical proteins and their annotated locations for XP_006714504.1

    Conserved Domains (2) summary
    cd03784
    Location:75382
    GT1_Gtf_like; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the ...
    COG1819
    Location:23415
    YjiC; UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism]
  7. XM_011513958.1XP_011512260.1  

    Related
    ENSP00000426100, OTTHUMP00000221783, ENST00000507113, OTTHUMT00000367193
    Conserved Domains (2) summary
    cd03784
    Location:95402
    GT1_Gtf_like; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the ...
    COG1819
    Location:43435
    YjiC; UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism]
  8. XM_005248243.3XP_005248300.1  

    See identical proteins and their annotated locations for XP_005248300.1

    Conserved Domains (2) summary
    cd03784
    Location:75382
    GT1_Gtf_like; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the ...
    COG1819
    Location:23415
    YjiC; UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism]
  9. XM_011513962.1XP_011512264.1  

    Conserved Domains (1) summary
    pfam00201
    Location:36284
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RNA

  1. XR_925587.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    35955886..36003836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)