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SLC9B2 solute carrier family 9 member B2 [ Homo sapiens (human) ]

Gene ID: 133308, updated on 12-May-2016
Official Symbol
SLC9B2provided by HGNC
Official Full Name
solute carrier family 9 member B2provided by HGNC
Primary source
HGNC:HGNC:25143
See related
Ensembl:ENSG00000164038 HPRD:14051; MIM:611789; Vega:OTTHUMG00000131125
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NHA2; NHE10; NHEDC2
Summary
Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 [PubMed 18000046]).[supplied by OMIM, Mar 2008]
Orthologs
Location:
4q24
Exon count:
14
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (103020230..103077371, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (103946647..103998480, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 9 member B1 Neighboring gene poly(A) binding protein cytoplasmic 1 pseudogene 7 Neighboring gene ACTR3B pseudogene 4 Neighboring gene 3-hydroxybutyrate dehydrogenase, type 2 Neighboring gene centromere protein E

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Clone Names

  • FLJ23984

Gene Ontology Provided by GOA

Function Evidence Code Pubs
monovalent cation:proton antiporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
hydrogen ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
ion transmembrane transport TAS
Traceable Author Statement
more info
 
positive regulation of osteoclast development IEA
Inferred from Electronic Annotation
more info
 
sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
Preferred Names
mitochondrial sodium/hydrogen exchanger 9B2
Names
NHE domain-containing protein 2
Na(+)/H(+) exchanger-like domain-containing protein 2
Na+/H+ exchanger domain containing 2
mitochondrial Na(+)/H(+) exchanger NHA2
mitochondrial sodium/hydrogen exchanger NHA2
sodium/hydrogen exchanger-like domain-containing protein 2
solute carrier family 9 subfamily B member 2
solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
solute carrier family 9, subfamily B (cation proton antiporter 2), member 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300754.1NP_001287683.1  mitochondrial sodium/hydrogen exchanger 9B2 isoform 2

    See identical proteins and their annotated locations for NP_001287683.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK297010, AK299888, BM683318, BX359760, DC297189
    Consensus CDS
    CCDS75174.1
    UniProtKB/TrEMBL
    B7Z488, B7Z676, E9PE63
    Related
    ENSP00000422477, OTTHUMP00000219474, ENST00000503230, OTTHUMT00000363235
    Conserved Domains (2) summary
    pfam00999
    Location:91453
    Na_H_Exchanger; Sodium/hydrogen exchanger family
    cl21520
    Location:119480
    Asp-Al_Ex; Predicted Permease Membrane Region
  2. NM_001300756.1NP_001287685.1  mitochondrial sodium/hydrogen exchanger 9B2 isoform 3

    See identical proteins and their annotated locations for NP_001287685.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the central and 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK172823, AK297010, AK299888, BM683318, BX359760
    Consensus CDS
    CCDS75173.1
    UniProtKB/Swiss-Prot
    Q86UD5
    UniProtKB/TrEMBL
    B7Z488, B7Z676
    Related
    ENSP00000425385, OTTHUMP00000219475, ENST00000503103, OTTHUMT00000363236
    Conserved Domains (1) summary
    cl21520
    Location:119356
    Asp-Al_Ex; Predicted Permease Membrane Region
  3. NM_178833.5NP_849155.2  mitochondrial sodium/hydrogen exchanger 9B2 isoform 1

    See identical proteins and their annotated locations for NP_849155.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK172823, AK297010, BM683318, BX359760
    Consensus CDS
    CCDS3662.1
    UniProtKB/Swiss-Prot
    Q86UD5
    UniProtKB/TrEMBL
    A0A024RDJ7, B7Z488
    Related
    ENSP00000378265, OTTHUMP00000161768, ENST00000394785, OTTHUMT00000253805
    Conserved Domains (1) summary
    cl21520
    Location:176537
    Asp-Al_Ex; Predicted Permease Membrane Region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

    Range
    103020230..103077371 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714085.1XP_006714148.1  

    See identical proteins and their annotated locations for XP_006714148.1

    UniProtKB/Swiss-Prot
    Q86UD5
    UniProtKB/TrEMBL
    A0A024RDJ7
    Related
    ENSP00000354574, OTTHUMP00000161769, ENST00000362026, OTTHUMT00000253806
    Conserved Domains (1) summary
    cl21520
    Location:176537
    Asp-Al_Ex; Predicted Permease Membrane Region
  2. XM_006714086.2XP_006714149.1  

    See identical proteins and their annotated locations for XP_006714149.1

    UniProtKB/TrEMBL
    E9PE63
    Conserved Domains (2) summary
    pfam00999
    Location:91453
    Na_H_Exchanger; Sodium/hydrogen exchanger family
    cl21520
    Location:119480
    Asp-Al_Ex; Predicted Permease Membrane Region
  3. XM_005262758.2XP_005262815.1  

    Conserved Domains (1) summary
    cl21520
    Location:176413
    Asp-Al_Ex; Predicted Permease Membrane Region
  4. XM_006714088.2XP_006714151.1  

    Conserved Domains (1) summary
    cl21520
    Location:14288
    Asp-Al_Ex; Predicted Permease Membrane Region

RNA

  1. XR_427529.2 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    103923120..103975001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)