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    PDCL2 phosducin-like 2 [ Homo sapiens ]

    Gene ID: 132954, updated on 11-May-2012
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    Summary

    Official Symbol
    PDCL2provided by HGNC
    Official Full Name
    phosducin-like 2provided by HGNC
    Primary source
    HGNC:29524
    See related
    Ensembl:ENSG00000163440; HPRD:15109; MIM:611676; Vega:OTTHUMG00000160674
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GCPHLP
    Summary
    This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    4q12
    Sequence :
    Chromosome: 4; NC_000004.11 (56422692..56458379, complement)
    See PDCL2 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506486 Neighboring gene transmembrane protein 165 Neighboring gene clock homolog (mouse) Neighboring gene neuromedin U Neighboring gene exocyst complex component 1 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Structure of the thioredoxin-fold domain of human phosducin-like protein 2. Lou X, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009 Feb 1. PMID 19193988.
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
    4. A novel germ line-specific gene of the phosducin-like protein (PhLP) family. A meiotic function conserved from yeast to mice. Lopez P, et al. J Biol Chem, 2003 Jan 17. PMID 12424248.
    5. Creation of genome-wide protein expression libraries using random activation of gene expression. Harrington JJ, et al. Nat Biotechnol, 2001 May. PMID 11329013.

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The X-ray crystal structure of the thioredoxin (Trx)-fold domain of PDCL2 has been solved and resembles the Trx-fold domain of rat; the presence of two molecules in an asymmetric unit is suggested.
      Title: Structure of the thioredoxin-fold domain of human phosducin-like protein 2.
    2. This publication pertains to mouse and suggests a role for phosducin-like 2 in germ cell maturation.
      Title: A novel germ line-specific gene of the phosducin-like protein (PhLP) family. A meiotic function conserved from yeast to mice.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q8N4E4 P31946 YWHAB    HPRD  PubMed  
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    General gene information

    Markers

    Genotypes

    Homology

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    General protein information

    Preferred Names
    phosducin-like protein 2
    Names
    phosducin-like protein 2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152401.2 → NP_689614.2  phosducin-like protein 2

      Status: REVIEWED

      Source sequence(s)
      AW629089, BC034431, BG198696
      Consensus CDS
      CCDS47059.1
      UniProtKB/Swiss-Prot
      Q8N4E4
      Related
      ENSP00000295645, OTTHUMP00000218694, ENST00000295645, OTTHUMT00000361659
      Conserved Domains (1) summary
      cd02988
      Location:8 – 186
      Blast Score: 582
      Phd_like_VIAF; Phosducin (Phd)-like family, Viral inhibitor of apoptosis (IAP)-associated factor (VIAF) subfamily; VIAF is a Phd-like protein that functions in caspase activation during apoptosis. It was identified as an IAP binding protein through a screen of a human ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      56422692..56458379, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      52371990..52407692, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC024243.8 (40286..75973) None
    genomic CH471057.1 EAX05469.1
    mRNA AW629089.1 None
    mRNA BC034431.1 AAH34431.1
    mRNA BG198696.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N4E4.2 GenPept UniProtKB/Swiss-Prot:Q8N4E4
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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