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CORT cortistatin [ Homo sapiens (human) ]

Gene ID: 1325, updated on 13-Sep-2014
Official Symbol
CORTprovided by HGNC
Official Full Name
cortistatinprovided by HGNC
Primary source
HGNC:HGNC:2257
Locus tag
UNQ307/PRO350
See related
Ensembl:ENSG00000241563; HPRD:04150; MIM:602784; Vega:OTTHUMG00000001906
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CST-14; CST-17; CST-29
Summary
This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010]
See CORT in Epigenomics, MapViewer
Location:
1p36.22
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (10449719..10452003)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (10509776..10512060)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phosphogluconate dehydrogenase Neighboring gene APITD1-CORT readthrough Neighboring gene apoptosis-inducing, TAF9-like domain 1 Neighboring gene DNA fragmentation factor, 45kDa, alpha polypeptide Neighboring gene peroxisomal biogenesis factor 14

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
  • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
  • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
    Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
  • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
    Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
  • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
    Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Readthrough APITD1-CORT

Readthrough gene: APITD1-CORT, Included gene: APITD1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
neuropeptide hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
synaptic transmission NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular space NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
cortistatin
Names
cortistatin
cortistatin-14
cortistatin-17
cortistatin-29
preprocortistatin
prepro-cortistatin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302.4NP_001293.3  cortistatin preproprotein

    See proteins identical to NP_001293.3

    Status: REVIEWED

    Source sequence(s)
    AL354956, AY358561, BC040034, BC119724, BF590359
    Consensus CDS
    CCDS117.2
    UniProtKB/Swiss-Prot
    O00230
    UniProtKB/TrEMBL
    Q8IUV6
    Related
    ENSP00000366248, OTTHUMP00000001901, ENST00000377049, OTTHUMT00000005410
    Conserved Domains (1) summary
    pfam03002
    Location:87104
    Somatostatin; Somatostatin/Cortistatin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    10449719..10452003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    9663393..9665676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    10497518..10499802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)