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Ddx5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 [ Mus musculus (house mouse) ]

Gene ID: 13207, updated on 8-May-2016
Official Symbol
Ddx5provided by MGI
Official Full Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5provided by MGI
Primary source
MGI:MGI:105037
See related
Ensembl:ENSMUSG00000020719 Vega:OTTMUSG00000003589
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p68; Hlr1; G17P1; HUMP68; 2600009A06Rik
Orthologs
Location:
11 70.01 cM; 11 E2
Exon count:
15
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (106780355..106789268, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (106641670..106649808, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene platelet/endothelial cell adhesion molecule 1 Neighboring gene mast cell immunoglobulin like receptor 1 Neighboring gene polymerase (DNA directed), gamma 2, accessory subunit Neighboring gene microRNA 3064 Neighboring gene centrosomal protein 95 Neighboring gene SMAD specific E3 ubiquitin protein ligase 2 Neighboring gene Smad nuclear interacting protein 1 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC118083

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
ATP-dependent RNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
androgen receptor binding ISO
Inferred from Sequence Orthology
more info
 
calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
pre-mRNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
transcription cofactor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA secondary structure unwinding IBA
Inferred from Biological aspect of Ancestor
more info
 
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 
intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
mRNA transcription ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
positive regulation of intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
regulation of androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
intracellular ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IC
Inferred by Curator
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
probable ATP-dependent RNA helicase DDX5
Names
D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 5
DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 5
DEAD box RNA helicase DEAD1
DEAD box protein 5
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5
RNA helicase p68
mDEAD1
p68 RNA helicase
NP_031866.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007840.3NP_031866.2  probable ATP-dependent RNA helicase DDX5

    See identical proteins and their annotated locations for NP_031866.2

    Status: PROVISIONAL

    Source sequence(s)
    AK166045
    Consensus CDS
    CCDS25562.1
    UniProtKB/TrEMBL
    Q8BTS0
    Related
    ENSMUSP00000021062, OTTMUSP00000003751, ENSMUST00000021062, OTTMUST00000007731
    Conserved Domains (4) summary
    pfam08061
    Location:551583
    P68HR; P68HR (NUC004) repeat
    cd00079
    Location:312444
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:96301
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    PTZ00110
    Location:6507
    PTZ00110; helicase; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    106780355..106789268 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532137.2XP_006532200.1  

    See identical proteins and their annotated locations for XP_006532200.1

    UniProtKB/TrEMBL
    Q8BTS0
    Conserved Domains (4) summary
    pfam08061
    Location:551583
    P68HR; P68HR (NUC004) repeat
    cd00079
    Location:312444
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:96301
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    PTZ00110
    Location:6507
    PTZ00110; helicase; Provisional
  2. XM_006532136.2XP_006532199.1  

    See identical proteins and their annotated locations for XP_006532199.1

    UniProtKB/TrEMBL
    Q8BTS0
    Conserved Domains (4) summary
    pfam08061
    Location:551583
    P68HR; P68HR (NUC004) repeat
    cd00079
    Location:312444
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:96301
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    PTZ00110
    Location:6507
    PTZ00110; helicase; Provisional
  3. XM_006532135.2XP_006532198.1  

    See identical proteins and their annotated locations for XP_006532198.1

    UniProtKB/TrEMBL
    Q8BTS0
    Conserved Domains (4) summary
    pfam08061
    Location:551583
    P68HR; P68HR (NUC004) repeat
    cd00079
    Location:312444
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:96301
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    PTZ00110
    Location:6507
    PTZ00110; helicase; Provisional

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    118511567..118519713 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)