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Ddx4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 [ Mus musculus (house mouse) ]

Gene ID: 13206, updated on 8-May-2016
Official Symbol
Ddx4provided by MGI
Official Full Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4provided by MGI
Primary source
MGI:MGI:102670
See related
Ensembl:ENSMUSG00000021758
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mvh; VASA; AV206478
Orthologs
Location:
13 D2.2; 13 63.87 cM
Exon count:
23
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 13 NC_000079.6 (112598333..112652629, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (113388541..113442518, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene interleukin 31 receptor A Neighboring gene predicted gene, 41066 Neighboring gene tubulin, alpha 1B pseudogene Neighboring gene solute carrier family 38, member 9 Neighboring gene heterogeneous nuclear ribonucleoprotein R pseudogene Neighboring gene predicted gene, 34024

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA methylation involved in gamete generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA secondary structure unwinding IBA
Inferred from Biological aspect of Ancestor
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
gene silencing by RNA IEA
Inferred from Electronic Annotation
more info
 
male meiosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
male meiosis I IMP
Inferred from Mutant Phenotype
more info
PubMed 
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
piRNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
sperm motility ISO
Inferred from Sequence Orthology
more info
 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromatoid body IDA
Inferred from Direct Assay
more info
PubMed 
chromatoid body ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
intracellular ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
pi-body IDA
Inferred from Direct Assay
more info
PubMed 
piP-body IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
probable ATP-dependent RNA helicase DDX4
Names
D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 4
DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 4
DEAD box polypeptide 4
DEAD box protein 4
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 4
mvh / m'vasa
vasa homolog
NP_001139357.1
NP_034159.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145885.1NP_001139357.1  probable ATP-dependent RNA helicase DDX4 isoform 1

    See identical proteins and their annotated locations for NP_001139357.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AK133366, BE860399, DT906923
    Consensus CDS
    CCDS49366.1
    UniProtKB/TrEMBL
    Q3V086
    Related
    ENSMUSP00000096769, ENSMUST00000099166
    Conserved Domains (3) summary
    smart00487
    Location:302502
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:513642
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:289496
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
  2. NM_010029.2NP_034159.1  probable ATP-dependent RNA helicase DDX4 isoform 2

    See identical proteins and their annotated locations for NP_034159.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK014844, BE860399, DT906923
    Consensus CDS
    CCDS26774.1
    UniProtKB/Swiss-Prot
    Q61496
    Related
    ENSMUSP00000075157, ENSMUST00000075748
    Conserved Domains (3) summary
    smart00487
    Location:276476
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:487616
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:263470
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p3 C57BL/6J

    Range
    112598333..112652629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517524.2XP_006517587.1  

    Conserved Domains (3) summary
    smart00487
    Location:307507
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:518647
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:294501
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
  2. XM_011244622.1XP_011242924.1  

    Conserved Domains (3) summary
    smart00487
    Location:307507
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:518647
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:294501
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
  3. XM_011244618.1XP_011242920.1  

    See identical proteins and their annotated locations for XP_011242920.1

    Conserved Domains (3) summary
    smart00487
    Location:312512
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:523652
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:299506
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
  4. XM_011244621.1XP_011242923.1  

    See identical proteins and their annotated locations for XP_011242923.1

    Conserved Domains (3) summary
    smart00487
    Location:312512
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:523652
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:299506
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
  5. XM_011244620.1XP_011242922.1  

    See identical proteins and their annotated locations for XP_011242922.1

    Conserved Domains (3) summary
    smart00487
    Location:312512
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:523652
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:299506
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
  6. XM_011244619.1XP_011242921.1  

    See identical proteins and their annotated locations for XP_011242921.1

    Conserved Domains (3) summary
    smart00487
    Location:312512
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:523652
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:299506
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

Alternate Mm_Celera

Genomic

  1. AC_000035.1 Alternate Mm_Celera

    Range
    116904120..116961259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)