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METTL6 methyltransferase like 6 [ Homo sapiens (human) ]

Gene ID: 131965, updated on 7-Dec-2014
Official Symbol
METTL6provided by HGNC
Official Full Name
methyltransferase like 6provided by HGNC
Primary source
HGNC:HGNC:28343
See related
Ensembl:ENSG00000206562; HPRD:14494; Vega:OTTHUMG00000156431
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
See METTL6 in Epigenomics, MapViewer
Location:
3p25.1
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 3 NC_000003.12 (15381275..15427547, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (15422782..15469054, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene SH3BP5 antisense RNA 1 Neighboring gene SH3-domain binding protein 5 (BTK-associated) Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 7 Neighboring gene ELL associated factor 1 Neighboring gene collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase Neighboring gene microRNA 4270

NHGRI GWAS Catalog

Description
Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC24132

Gene Ontology Provided by GOA

Function Evidence Code Pubs
methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
methylation IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
methyltransferase-like protein 6
Names
methyltransferase-like protein 6
NP_689609.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301790.1NP_001288719.1  methyltransferase-like protein 6 isoform 2

    See proteins identical to NP_001288719.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC027125, AK293370, BG701912, CX872865, Z44406
    Conserved Domains (1) summary
    cd02440
    Location:70142
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_001301791.1NP_001288720.1  methyltransferase-like protein 6 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains multiple coding region differences, including an alternate 3' terminal exon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC027125, BG701912, BU183521, CA430635
    Conserved Domains (1) summary
    cd02440
    Location:82177
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. NM_001301792.1NP_001288721.1  methyltransferase-like protein 6 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC027125, BC022400, BG701912, BI913767, CX872865, Z44406
    Conserved Domains (1) summary
    cd02440
    Location:82177
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  4. NM_152396.3NP_689609.2  methyltransferase-like protein 6 isoform 1

    See proteins identical to NP_689609.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC027125, BC022400, BG701912, CX872865, Z44406
    Consensus CDS
    CCDS43056.1
    UniProtKB/Swiss-Prot
    Q8TCB7
    Conserved Domains (2) summary
    cd02440
    Location:82187
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    COG0500
    Location:57215
    SmtA; SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000003.12 

    Range
    15381275..15427547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264867.2XP_005264924.1  

    See proteins identical to XP_005264924.1

    UniProtKB/Swiss-Prot
    Q8TCB7
    Related
    ENSP00000407613, OTTHUMP00000210877, ENST00000443029, OTTHUMT00000346373
    Conserved Domains (2) summary
    cd02440
    Location:82187
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    COG0500
    Location:57215
    SmtA; SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]
  2. XM_006712972.1XP_006713035.1  

    Conserved Domains (1) summary
    cd02440
    Location:82177
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. XM_006712971.1XP_006713034.1  

    Related
    ENSP00000410726, OTTHUMP00000210874, ENST00000450816, OTTHUMT00000346368
    Conserved Domains (1) summary
    cd02440
    Location:70142
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  4. XM_006712970.1XP_006713033.1  

    See proteins identical to XP_006713033.1

    UniProtKB/Swiss-Prot
    Q8TCB7
    Related
    ENSP00000373300, OTTHUMP00000209876, ENST00000383790, OTTHUMT00000344161
    Conserved Domains (2) summary
    cd02440
    Location:82187
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    COG0500
    Location:57215
    SmtA; SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]
  5. XM_006712969.1XP_006713032.1  

    See proteins identical to XP_006713032.1

    UniProtKB/Swiss-Prot
    Q8TCB7
    Conserved Domains (2) summary
    cd02440
    Location:82187
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    COG0500
    Location:57215
    SmtA; SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]
  6. XM_005264869.2XP_005264926.1  

    Conserved Domains (1) summary
    cd02440
    Location:82177
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  7. XM_005264870.2XP_005264927.1  

    See proteins identical to XP_005264927.1

    UniProtKB/Swiss-Prot
    Q8TCB7
    Conserved Domains (1) summary
    cd02440
    Location:82177
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 

    Range
    15402252..15419927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000135.1 

    Range
    15386707..15404381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)