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    Ddb1 damage specific DNA binding protein 1 [ Mus musculus ]

    Gene ID: 13194, updated on 11-May-2012
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    Summary

    Official Symbol
    Ddb1provided by MGI
    Official Full Name
    damage specific DNA binding protein 1provided by MGI
    Primary source
    MGI:1202384
    See related
    Ensembl:ENSMUSG00000024740
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    127kDa; AA408517; p127-Ddb1
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    Genomic context

    Location :
    19 centromere; 19 5.0 cM
    Sequence :
    Chromosome: 19; NC_000085.6 (10605625..10629822)
    See Ddb1 in Epigenomics, MapViewer

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene cytochrome b, ascorbate dependent 3 Neighboring gene dihydroxyacetone kinase 2 homolog (yeast) Neighboring gene RIKEN cDNA 4930524O05 gene Neighboring gene von Willebrand factor C and EGF domains Neighboring gene pepsinogen 5, group I

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Identification of DNA-damage DNA-binding protein 1 as a conditional essential factor for cytomegalovirus replication in interferon-γ-stimulated cells. Trilling M, et al. PLoS Pathog, 2011 Jun. PMID 21698215.
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750.
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068.
    4. Hepatocyte-specific deletion of DDB1 induces liver regeneration and tumorigenesis. Yamaji S, et al. Proc Natl Acad Sci U S A, 2010 Dec 21. PMID 21135245.
    5. An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Pardo M, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362542.

    See all (34) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. In a constructive process, pM27 recruits DDB1 to exploit ubiquitin ligase complexes catalyzing the obstruction of the STAT2-dependent antiviral state of cells to permit viral replication.
      Title: Identification of DNA-damage DNA-binding protein 1 as a conditional essential factor for cytomegalovirus replication in interferon-γ-stimulated cells.
    2. Hepatocyte-specific deletion of DDB1 induces liver regeneration and tumorigenesis.
      Title: Hepatocyte-specific deletion of DDB1 induces liver regeneration and tumorigenesis.
    3. DDB1 plays an important role in development by controlling levels of cell cycle regulators and thereby maintaining genomic stability.
      Title: DDB1 is essential for genomic stability in developing epidermis.
    4. These results indicate that DDB1 plays an essential role in maintaining viability and genomic integrity of dividing cells.
      Title: Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells.
    Submit: New GeneRIF Correction
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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:199074 BioGRID:120765 AMBRA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:114103 COPS3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:119324 COPS4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:116176 COPS6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:119130 COPS7A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:122237 COPS7B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:119360 CRBN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:114029 CUL4A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:114028 CUL4B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:122612 DCAF10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:123251 DCAF11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:117377 DCAF12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:124705 DCAF15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:120224 DCAF16    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:117545 DCAF4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:120933 DCAF6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:119121 DCAF8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:122485 DDA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:108009 DDB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:108010 DDB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:119582 DTL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:107581 ERCC8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:109131 GPS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:115950 NUDC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:114254 PAGE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:117618 PHGDH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:202313 Pou5f1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:111887 RCN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:117569 TRPC4AP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:204323 Trp53    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:199074 BioGRID:115079 VPRBP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199074 BioGRID:116677 WDTC1    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the Ddb1 gene: The Ddb1 gene is conserved in human, chimpanzee, , dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Human, Rat)

    Pathways from BioSystems

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Wnt receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell cycle checkpoint ISO
    Inferred from Sequence Orthology
    more info
    		  
    proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    CUL4 RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    Cul4A-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    Cul4B-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
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    General protein information

    Preferred Names
    DNA damage-binding protein 1
    Names
    DNA damage-binding protein 1
    DDB p127 subunit
    DNA repair protein
    UV-damaged DNA-binding factor
    damaged-DNA recognition protein 1
    damage-specific DNA-binding protein 1
    damage-specific DNA-binding protein, DNA repair
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015735.1 → NP_056550.1  DNA damage-binding protein 1

      Status: PROVISIONAL

      Source sequence(s)
      AB026432
      Consensus CDS
      CCDS37915.1
      UniProtKB/Swiss-Prot
      Q3U1J4
      Related
      ENSMUSP00000025649, ENSMUST00000025649
      Conserved Domains (2) summary
      pfam03178
      Location:789 – 1099
      Blast Score: 745
      CPSF_A; CPSF A subunit region
      pfam10433
      Location:75 – 546
      Blast Score: 971
      MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term

    RefSeqs of Annotated Genomes: Build 38.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38 C57BL/6J

      Range
      10605625..10629822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000041.1 Alternate Mm_Celera

      Range
      11301601..11325808
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AC125093.4 None
    genomic AC132247.3 (145208..163209) None
    genomic CH466534.1 EDL41370.1 mixed
    mRNA AB026432.1 BAA84699.1
    mRNA AF159853.1 AAD42230.1
    mRNA AJ416426.1 CAC94909.1 BALB/c
    mRNA AK004284.1 None C57BL/6J
    mRNA AK145328.1 BAE26370.1 C57BL/6J
    mRNA AK146522.1 BAE27231.1 C57BL/6J
    mRNA AK152228.1 BAE31055.1 C57BL/6J
    mRNA AK154303.1 BAE32502.1 NOD
    mRNA AK155020.1 BAE32993.1 NOD
    mRNA AK155920.1 BAE33503.1 C57BL/6J
    mRNA AK157491.1 BAE34102.1 NOD
    mRNA AK179316.1 None
    mRNA AK181944.1 None
    mRNA AK184962.1 None
    mRNA AK186096.1 None
    mRNA AK186475.1 None
    mRNA AK187992.1 None
    mRNA AK188547.1 None
    mRNA AK189784.1 None
    mRNA AK191685.1 None
    mRNA AK192850.1 None
    mRNA AK195557.1 None
    mRNA AK195744.1 None
    mRNA AK197381.1 None
    mRNA AK202600.1 None
    mRNA AK209080.1 None
    mRNA AK215812.1 None
    mRNA AK217207.1 None
    mRNA BC002210.1 AAH02210.1
    mRNA BC009661.1 AAH09661.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U1J4.2 GenPept UniProtKB/Swiss-Prot:Q3U1J4
    Q3ULS8 GenPept UniProtKB/TrEMBL:Q3ULS8
    Q91YC8 GenPept UniProtKB/TrEMBL:Q91YC8
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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    Miscellaneous

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