GRK7 G protein-coupled receptor kinase 7 [Homo sapiens] - Gene

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Summary

Official Symbol: GRK7provided by HGNC
Official Full Name: G protein-coupled receptor kinase 7provided by HGNC
Primary source: HGNC:17031
See related: Ensembl:ENSG00000114124; HPRD:07378; MIM:606987; Vega:OTTHUMG00000159068
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GPRK7
Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 3q24

Sequence :: Chromosome: 3; NC_000003.11 (141497043..141535892)

See GRK7 in Epigenomics, MapViewer

Chromosome 3 - NC_000003.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Defects in GRK1 or GRK7 cause patients to suffer from an inability to properly deactivate rhodopsin leading to problems with recovery and dark adaptation.
Title: A tale of two kinases in rods and cones.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
synthesis of 29 of GRK1 or GRK7 partial peptides that cover the entire sequence of GRK1/GRK7, to see which interacts with recoverin.
Title: Amino acid residues in GRK1/GRK7 responsible for interaction with S-modulin/recoverin.
Phosphorylation of GRK1 and GRK7 by PKA occurs in the dark, when cAMP levels in photoreceptor cells are elevated.
Title: Phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase attenuates their enzymatic activities.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
Q8WTQ7	O43924	PDE6D		HPRD	PubMed
BioGRID:126297	BioGRID:110811	NEDD4		BioGRID	PubMed	Biochemical Activity

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
G-protein coupled receptor kinase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
rhodopsin kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
protein autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
response to stimulus	IEA Inferred from Electronic Annotation more info
signal transduction	IEA Inferred from Electronic Annotation more info
termination of G-protein coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: G protein-coupled receptor kinase 7

Names: G protein-coupled receptor kinase 7; g protein-coupled receptor kinase GRK7

NP_631948.1

EC 2.7.11.14

EC 2.7.11.16

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139209.2 → NP_631948.1 G protein-coupled receptor kinase 7

Status: REVIEWED

Source sequence(s)

AF439409

Consensus CDS

CCDS3120.1

UniProtKB/Swiss-Prot

Q8WTQ7

Related

ENSP00000264952, OTTHUMP00000214002, ENST00000264952, OTTHUMT00000353168

Conserved Domains (3) summary

cd05607
Location:197 – 474
Blast Score: 1392

STKc_GRK7; Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 7

cd08749
Location:40 – 181
Blast Score: 543

RGS_GRK7; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 7 (GRK7)

smart00220
Location:195 – 454
Blast Score: 608

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000003.11 Reference GRCh37.p5 Primary Assembly

Range

141497043..141535892

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000135.1 Alternate HuRef

Range

138870724..138909591

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC112504.6 (144499..183348)	None
genomic	CH471052.2	EAW78990.1
mRNA	AF282269.1	AAL33880.1
mRNA	AF439409.1	AAL48216.1
other-genetic	BC148327.1	AAI48328.1
other-genetic	BC152977.1	AAI52978.1