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TPRA1 transmembrane protein adipocyte associated 1 [ Homo sapiens (human) ]

Gene ID: 131601, updated on 12-May-2016
Official Symbol
TPRA1provided by HGNC
Official Full Name
transmembrane protein adipocyte associated 1provided by HGNC
Primary source
HGNC:HGNC:30413
See related
Ensembl:ENSG00000163870 HPRD:16318; MIM:608336; Vega:OTTHUMG00000159639
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR175; TPRA40; TMEM227
Orthologs
Location:
3q21.2
Exon count:
16
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (127573064..127595059, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (127291907..127309602, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927123 Neighboring gene uncharacterized LOC105374094 Neighboring gene long intergenic non-protein coding RNA 1471 Neighboring gene microRNA 6825 Neighboring gene microRNA 7976 Neighboring gene minichromosome maintenance complex component 2 Neighboring gene podocalyxin like 2

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ32197

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
aging TAS
Traceable Author Statement
more info
PubMed 
embryonic cleavage IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of mitotic cell cycle phase transition IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
transmembrane protein adipocyte-associated 1
Names
G protein-coupled receptor 175
integral membrane protein GPR175
seven transmembrane domain orphan receptor
transmembrane domain protein regulated in adipocytes 40 kDa
transmembrane protein 227
transmembrane protein, adipocyte asscociated 1
transmembrane protein, adipocyte associated 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136053.2NP_001129525.1  transmembrane protein adipocyte-associated 1 isoform 1

    See identical proteins and their annotated locations for NP_001129525.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC050711, BM665705, HY066741
    Consensus CDS
    CCDS3042.1
    UniProtKB/Swiss-Prot
    Q86W33
    Related
    ENSP00000347748, OTTHUMP00000216053, ENST00000355552, OTTHUMT00000356624
    Conserved Domains (1) summary
    pfam10160
    Location:35291
    Tmemb_40; Predicted membrane protein
  2. NM_001142646.2NP_001136118.1  transmembrane protein adipocyte-associated 1 isoform 2

    See identical proteins and their annotated locations for NP_001136118.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive exons in the 3' coding region, which results in a reading frameshift, as compared to variant 1. The resulting isoform (2) has a shorter and different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AF289568, BC050711, BM665705, HY066741
    Consensus CDS
    CCDS46899.1
    UniProtKB/Swiss-Prot
    Q86W33
    Related
    ENSP00000296210, OTTHUMP00000216055, ENST00000296210, OTTHUMT00000356626
    Conserved Domains (1) summary
    pfam10160
    Location:35204
    Tmemb_40; Predicted membrane protein

RNA

  1. NR_073377.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC017058, BM665705, HY066741
    Related
    ENST00000393400, OTTHUMT00000356625

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    127573064..127595059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713497.2XP_006713560.1  

    See identical proteins and their annotated locations for XP_006713560.1

    UniProtKB/Swiss-Prot
    Q86W33
    Conserved Domains (1) summary
    pfam10160
    Location:35291
    Tmemb_40; Predicted membrane protein
  2. XM_011512420.1XP_011510722.1  

    Conserved Domains (1) summary
    pfam10160
    Location:35166
    Tmemb_40; Predicted membrane protein
  3. XM_006713496.2XP_006713559.1  

    See identical proteins and their annotated locations for XP_006713559.1

    UniProtKB/Swiss-Prot
    Q86W33
    Related
    ENSP00000418298, OTTHUMP00000216057, ENST00000489960, OTTHUMT00000356628
    Conserved Domains (1) summary
    pfam10160
    Location:35291
    Tmemb_40; Predicted membrane protein
  4. XM_011512421.1XP_011510723.1  

    See identical proteins and their annotated locations for XP_011510723.1

    UniProtKB/Swiss-Prot
    Q86W33
    Conserved Domains (1) summary
    pfam10160
    Location:35291
    Tmemb_40; Predicted membrane protein
  5. XM_006713495.2XP_006713558.1  

    See identical proteins and their annotated locations for XP_006713558.1

    UniProtKB/Swiss-Prot
    Q86W33
    Conserved Domains (1) summary
    pfam10160
    Location:35291
    Tmemb_40; Predicted membrane protein
  6. XM_011512422.1XP_011510724.1  

    See identical proteins and their annotated locations for XP_011510724.1

    UniProtKB/Swiss-Prot
    Q86W33
    Related
    ENSP00000413428, OTTHUMP00000216058, ENST00000450633, OTTHUMT00000356629
    Conserved Domains (1) summary
    pfam10160
    Location:35291
    Tmemb_40; Predicted membrane protein

RNA

  1. XR_924101.1 RNA Sequence

  2. XR_924102.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    127255253..127272919 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016372.2: Suppressed sequence

    Description
    NM_016372.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.