KLF6 Kruppel-like factor 6 [Homo sapiens] - Gene

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Summary

Official Symbol: KLF6provided by HGNC
Official Full Name: Kruppel-like factor 6provided by HGNC
Primary source: HGNC:2235
Locus tag: RP11-184A2.1
See related: Ensembl:ENSG00000067082; HPRD:03632; MIM:602053; Vega:OTTHUMG00000017567
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GBF; ZF9; BCD1; CBA1; CPBP; PAC1; ST12; COPEB; DKFZp686N0199
Summary: This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009]

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Genomic context

Location :: 10p15

Sequence :: Chromosome: 10; NC_000010.10 (3818188..3827473, complement)

See KLF6 in Epigenomics, MapViewer

Chromosome 10 - NC_000010.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

KLF6 and Sp1 may participate in the inducible transcriptional regulation of TMSG-1 in prostate carcinoma cells.
Title: [Transcriptional activation of TMSG-1 by complex of KLF6 and Sp1].
KLF6 playing a role as transcriptional regulator of relevant genes for placental differentiation and physiology such as betahCG and PSG
Title: Krüppel-like factor 6 expression changes during trophoblast syncytialization and transactivates ßhCG and PSG placental genes.
The authors have identified KLF6 as a key transcription factor required for trans-activation of TGF beta gene during human respiratory syncytial virus infection.
Title: Krüppel-like factor 6 regulates transforming growth factor-β gene expression during human respiratory syncytial virus infection.
Low KLF6 is associated with acute myeloid leukemia.
Title: Deregulated expression of Kruppel-like factors in acute myeloid leukemia.
The Kruppel-like transcription factor family has an essential role in the regulation of many processes including cell proliferation, differentiation, signal transduction, oncogenesis, and cell death.
Title: Biology of Krüppel-like factor 6 transcriptional regulator in cell life and death.
Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression.
Title: Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression.
The role of KLF6 and PPAR-gamma in MIP-3alpha transcriptional regulation, was determined.
Title: The roles of Kruppel-like factor 6 and peroxisome proliferator-activated receptor-γ in the regulation of macrophage inflammatory protein-3α at early onset of diabetes.
KLF6 mutations were found in 45%, 27% and 26% of colorectal carcinoma, ulcerative colitis and polyp cases, respectively, in Egyptian patients. Most of the mutations detected were located at exon 2.
Title: Role of KLF6 tumor suppressor gene mutations in the development of colorectal carcinoma in an Egyptian population.
Decreased expression of KLF6 is associated with gastric carcinoma.
Title: Decreased expression of KLF6 and its significance in gastric carcinoma.
KLF6 IVS1 -27AA genotype was associated with a decreased risk of gastric cancer.
Title: The Krüppel-like factor 6 genotype is associated with gastric cancer in a Chinese population.

Submit: New GeneRIF Correction See all (78)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Products	Interactant	Other Gene	Source	Pubs	Description
NP_001291.3	NP_444284.1	CCND1	BIND	PubMed	KLF6 interacts with Cyclin D1.
Q99612	O95445	APOM	HPRD	PubMed
Q99612	Q9HCU4	CELSR2	HPRD	PubMed
Q99612	Q96KQ7	EHMT2	HPRD	PubMed
Q99612	Q12789	GTF3C1	HPRD	PubMed
Q99612	O15379	HDAC3	HPRD	PubMed
Q99612	O43474	KLF4	HPRD	PubMed
Q99612	Q9NRX1	PNO1	HPRD	PubMed
Q99612	Q14181	POLA2	HPRD	PubMed
Q99612	P08047	SP1	HPRD	PubMed
Q99612	P04637	TP53	HPRD	PubMed
BioGRID:107711	BioGRID:121006	APOM	BioGRID	PubMed	Two-hybrid
BioGRID:107711	BioGRID:108201	E2F1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107711	BioGRID:116123	EHMT2	BioGRID	PubMed	Two-hybrid
BioGRID:107711	BioGRID:108399	FBL	BioGRID	PubMed	Reconstituted Complex
BioGRID:107711	BioGRID:109230	GTF3C1	BioGRID	PubMed	Two-hybrid
BioGRID:107711	BioGRID:114368	HDAC3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107711	BioGRID:114726	KLF4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107711	BioGRID:115783	NOP56	BioGRID	PubMed	Reconstituted Complex
BioGRID:107711	BioGRID:114012	NR0B2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107711	BioGRID:117807	NUFIP1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107711	BioGRID:121232	PNO1	BioGRID	PubMed	Two-hybrid
BioGRID:107711	BioGRID:117176	POLA2	BioGRID	PubMed	Two-hybrid
BioGRID:107711	BioGRID:112550	SP1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107711	BioGRID:112743	TAF9	BioGRID	PubMed	Reconstituted Complex
BioGRID:107711	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
B cell differentiation	NAS Non-traceable Author Statement more info	PubMed
cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
positive regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
positive regulation of transcription, DNA-dependent	TAS Traceable Author Statement more info	PubMed
regulation of transcription, DNA-dependent	NAS Non-traceable Author Statement more info
wound healing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
intracellular	IEA Inferred from Electronic Annotation more info
nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

Preferred Names: Krueppel-like factor 6

Names: Krueppel-like factor 6; proto-oncogene BCD1; GC-rich binding factor; B-cell-derived protein 1; transcription factor Zf9; protooncogene B-cell derived 1; GC-rich sites-binding factor GBF; Kruppel-like zinc finger protein Zf9; core promoter element binding protein; core promoter element-binding protein; suppressor of tumorigenicity 12 protein; suppression of tumorigenicity 12 (prostate)

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012277.1 RefSeqGene

Range

5001..14286

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001160124.1 → NP_001153596.1 Krueppel-like factor 6 isoform B

Status: REVIEWED

Description

Transcript Variant: This variant (B), also known as sv2, uses an alternate splice site in the central coding region that results in a frameshift, compared to variant A. The resulting isoform (B) has a shorter and distinct C-terminus, compared to isoform A.

Source sequence(s)

AL450322, BC000311, BP357332, BQ017028, CR994352

UniProtKB/TrEMBL

D3GC14

UniProtKB/Swiss-Prot

Q99612

Conserved Domains (1) summary

pfam13465
Location:204 – 229
Blast Score: 91

zf-H2C2_2; Zinc-finger double domain
NM_001160125.1 → NP_001153597.1 Krueppel-like factor 6 isoform C

Status: REVIEWED

Description

Transcript Variant: This variant (C), also known as sv3, lacks an alternate exon in the 3' coding region that results in a frameshift, compared to variant A. The resulting isoform (C) has a shorter and distinct C-terminus, compared to isoform A.

Source sequence(s)

AL450322, BC000311, BM695496, BP357332, BQ017028

Consensus CDS

CCDS53490.1

UniProtKB/TrEMBL

F5H3M5

UniProtKB/Swiss-Prot

Q99612

Related

ENSP00000445301, ENST00000542957
NM_001300.5 → NP_001291.3 Krueppel-like factor 6 isoform A

Status: REVIEWED

Description

Transcript Variant: This variant (A) represents the longest transcript and encodes the longest isoform (A).

Source sequence(s)

AL450322, BC000311, BP357332, BQ017028

Consensus CDS

CCDS7060.1

UniProtKB/Swiss-Prot

Q99612

Related

ENSP00000419923, OTTHUMP00000018986, ENST00000497571, OTTHUMT00000046495

Conserved Domains (2) summary

COG5048
Location:177 – 265
Blast Score: 98

COG5048; FOG: Zn-finger [General function prediction only]

pfam13465
Location:246 – 271
Blast Score: 87

zf-H2C2_2; Zinc-finger double domain

RNA

NR_027653.1 RNA Sequence

Description

Transcript Variant: This variant (D), also known as sv1, uses an alternate splice site, compared to variant A. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant A, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL450322, BC000311, BP357332, BQ017028, CR975091

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000010.10 Reference GRCh37.p5 Primary Assembly

Range

3818188..3827473, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000142.1 Alternate HuRef

Range

3754750..3764030, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001008490.1: Suppressed sequence

Description

NM_001008490.1: This RefSeq was suppressed because the 3'UTR structure is not strongly supported and it renders the transcript a candidate for nonsense-mediated decay (NMD).

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF284036.1	AAM73548.1
genomic	AL450322.17	CAH71010.1
		CAH71011.1
genomic	AL450322.17	CAH71010.1
		CAH71011.1
genomic	AL513303.11	CAH74049.1
		CAH74050.1
genomic	AL513303.11	CAH74049.1
		CAH74050.1
genomic	CH471072.2	EAW86476.1
		EAW86477.1
		EAW86478.1
		EAW86479.1
genomic	HI573934.1	CBX47456.1
genomic	HI573936.1	CBX47457.1
mRNA	AB017493.1	BAA33050.1
mRNA	AF001461.1	AAC39929.1
mRNA	AI355637.1	None
mRNA	AK293259.1	BAG56791.1
mRNA	AK316596.1	BAG38183.1
mRNA	BC000311.2	AAH00311.1
mRNA	BC004301.1	None
mRNA	BC015987.1	None
mRNA	BM544849.1	None
mRNA	BM695496.1	None
mRNA	BP357332.1	None
mRNA	BQ017028.1	None
mRNA	BT006778.1	AAP35424.1
mRNA	BX537374.1	CAD97616.1
mRNA	CD742988.1	None
mRNA	CR975091.1	None
mRNA	CR994352.1	None
mRNA	FJ619623.1	ACU45419.1
mRNA	U44975.1	AAC23699.1
mRNA	U51869.1	AAB94792.1
		AAB94793.1
other-genetic	DQ890752.2	ABM81678.1
other-genetic	HQ447106.1	ADQ31593.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
O43838	GenPept	UniProtKB/TrEMBL:O43838
O43839	GenPept	UniProtKB/TrEMBL:O43839
Q7Z3W8	GenPept	UniProtKB/TrEMBL:Q7Z3W8
Q99612.3	GenPept	UniProtKB/Swiss-Prot:Q99612