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TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase [ Homo sapiens (human) ]

Gene ID: 131405, updated on 26-May-2016
Official Symbol
TRIM71provided by HGNC
Official Full Name
tripartite motif containing 71, E3 ubiquitin protein ligaseprovided by HGNC
Primary source
HGNC:HGNC:32669
See related
Ensembl:ENSG00000206557
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIN41; LIN-41
Summary
The protein encoded by this gene is an E3 ubiquitin-protein ligase that binds with miRNAs and maintains the growth and upkeep of embryonic stem cells. This gene also is involved in the G1-S phase transition of the cell cycle. [provided by RefSeq, Dec 2015]
Orthologs
Location:
3p22.3
Exon count:
4
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (32818018..32892279)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (32859510..32933771)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L23a pseudogene 43 Neighboring gene putative uncharacterized protein UNQ6490/PRO21339 Neighboring gene uncharacterized LOC105377022 Neighboring gene C-C motif chemokine receptor 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
NHGRI GWA Catalog
  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ligase activity IEA
Inferred from Electronic Annotation
more info
 
miRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
translation repressor activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
3'-UTR-mediated mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
G1/S transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
fibroblast growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
miRNA mediated inhibition of translation ISS
Inferred from Sequence or Structural Similarity
more info
 
miRNA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
neural tube closure IEA
Inferred from Electronic Annotation
more info
 
neural tube development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
 
protein autoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of gene silencing by miRNA ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neural precursor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
stem cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasmic mRNA processing body ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
E3 ubiquitin-protein ligase TRIM71
Names
abnormal cell LINeage LIN-41
homolog of C. elegans Lin-41
protein lin-41 homolog
tripartite motif-containing 71
tripartite motif-containing protein 71
NP_001034200.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039111.2NP_001034200.1  E3 ubiquitin-protein ligase TRIM71

    See identical proteins and their annotated locations for NP_001034200.1

    Status: REVIEWED

    Source sequence(s)
    AC139452, AW196612, DQ232881
    Consensus CDS
    CCDS43060.1
    UniProtKB/Swiss-Prot
    Q2Q1W2
    Related
    ENSP00000373272, OTTHUMP00000208607, ENST00000383763, OTTHUMT00000341565
    Conserved Domains (6) summary
    smart00502
    Location:314444
    BBC; B-Box C-terminal domain
    COG3391
    Location:609859
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00021
    Location:278311
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam00630
    Location:482577
    Filamin; Filamin/ABP280 repeat
    cd05819
    Location:525554
    NHL; NHL repeat [structural motif]
    cd14954
    Location:584868
    NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    32818018..32892279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    32809475..32883728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)