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Dag1 dystroglycan 1 [ Mus musculus (house mouse) ]

Gene ID: 13138, updated on 8-May-2016
Official Symbol
Dag1provided by MGI
Official Full Name
dystroglycan 1provided by MGI
Primary source
MGI:MGI:101864
See related
Ensembl:ENSMUSG00000039952 Vega:OTTMUSG00000050793
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DG; Dp71; Dp427; D9Wsu13e
Summary
This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. A complete lack of the encoded protein in mice results in embryonic lethality due to the disorganization of Reichert's membrane. Chimeric mice deficient in the encoded protein overcome embryonic lethality but develop a progressive muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Nov 2015]
Orthologs
Location:
9 F2; 9 59.08 cM
Exon count:
6
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 9 NC_000075.6 (108204861..108263958, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (108108289..108166067, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene acylpeptide hydrolase Neighboring gene bassoon Neighboring gene RIKEN cDNA 4930447F24 gene Neighboring gene nicolin 1 Neighboring gene aminomethyltransferase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
actin binding ISO
Inferred from Sequence Orthology
more info
 
alpha-actinin binding ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
dystroglycan binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
structural constituent of muscle ISO
Inferred from Sequence Orthology
more info
 
tubulin binding ISO
Inferred from Sequence Orthology
more info
 
vinculin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
NLS-bearing protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
Schwann cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
basement membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching involved in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium-dependent cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
commissural neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoskeletal anchoring at plasma membrane ISO
Inferred from Sequence Orthology
more info
 
epithelial tube branching involved in lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
microtubule anchoring ISO
Inferred from Sequence Orthology
more info
 
modulation by virus of host morphology or physiology ISO
Inferred from Sequence Orthology
more info
 
morphogenesis of an epithelial sheet IMP
Inferred from Mutant Phenotype
more info
PubMed 
myelination in peripheral nervous system IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
nerve maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of basement membrane assembly involved in embryonic body morphogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
regulation of gastrulation ISO
Inferred from Sequence Orthology
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
basement membrane ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell adherens junction ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
contractile ring ISO
Inferred from Sequence Orthology
more info
 
costamere ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
dystroglycan complex IDA
Inferred from Direct Assay
more info
PubMed 
dystrophin-associated glycoprotein complex ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
filopodium ISO
Inferred from Sequence Orthology
more info
 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with focal adhesion ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
lamellipodium ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
node of Ranvier IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
sarcolemma ISO
Inferred from Sequence Orthology
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
dystroglycan
Names
dystrophin associated glycoprotein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276481.1NP_001263410.1  dystroglycan preproprotein

    See identical proteins and their annotated locations for NP_001263410.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same protein.
    Source sequence(s)
    AC168217, AK038702, AV085570, CA327718, CB289895, U43512
    Consensus CDS
    CCDS23518.1
    UniProtKB/Swiss-Prot
    Q62165
    UniProtKB/TrEMBL
    Q544G5
    Conserved Domains (3) summary
    pfam05454
    Location:604893
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    cd11303
    Location:60161
    Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
    cd11305
    Location:180302
    alpha_DG_C; C-terminal domain of alpha dystroglycan
  2. NM_001276482.1NP_001263411.1  dystroglycan preproprotein

    See identical proteins and their annotated locations for NP_001263411.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same protein.
    Source sequence(s)
    AC168217, AK038702, AV085570, CB289895, CD578569, U43512
    Consensus CDS
    CCDS23518.1
    UniProtKB/Swiss-Prot
    Q62165
    UniProtKB/TrEMBL
    Q544G5
    Related
    ENSMUSP00000079294, OTTMUSP00000069232, ENSMUST00000080435, OTTMUST00000128730
    Conserved Domains (3) summary
    pfam05454
    Location:604893
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    cd11303
    Location:60161
    Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
    cd11305
    Location:180302
    alpha_DG_C; C-terminal domain of alpha dystroglycan
  3. NM_001276485.1NP_001263414.1  dystroglycan preproprotein

    See identical proteins and their annotated locations for NP_001263414.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same protein.
    Source sequence(s)
    AC168217, AK038702, AK053886, AV085570, CJ130634, U43512
    Consensus CDS
    CCDS23518.1
    UniProtKB/Swiss-Prot
    Q62165
    UniProtKB/TrEMBL
    Q544G5, Q8BPJ7
    Related
    ENSMUSP00000128531, OTTMUSP00000069233, ENSMUST00000166905, OTTMUST00000128731
    Conserved Domains (3) summary
    pfam05454
    Location:604893
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    cd11303
    Location:60161
    Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
    cd11305
    Location:180302
    alpha_DG_C; C-terminal domain of alpha dystroglycan
  4. NM_001276486.1NP_001263415.1  dystroglycan preproprotein

    See identical proteins and their annotated locations for NP_001263415.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same protein.
    Source sequence(s)
    AC168217, AK036174, AK038702, AV085570, CJ130634, U43512
    Consensus CDS
    CCDS23518.1
    UniProtKB/Swiss-Prot
    Q62165
    UniProtKB/TrEMBL
    Q544G5, Q8CBE6
    Related
    ENSMUSP00000142109, OTTMUSP00000069235, ENSMUST00000191899, OTTMUST00000128733
    Conserved Domains (3) summary
    pfam05454
    Location:604893
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    cd11303
    Location:60161
    Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
    cd11305
    Location:180302
    alpha_DG_C; C-terminal domain of alpha dystroglycan
  5. NM_001276492.1NP_001263421.1  dystroglycan preproprotein

    See identical proteins and their annotated locations for NP_001263421.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same protein.
    Source sequence(s)
    AC168217, AK036174, AK038702, AV085570, BY256937, CB289895, U43512
    Consensus CDS
    CCDS23518.1
    UniProtKB/Swiss-Prot
    Q62165
    UniProtKB/TrEMBL
    Q544G5, Q8CBE6
    Conserved Domains (3) summary
    pfam05454
    Location:604893
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    cd11303
    Location:60161
    Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
    cd11305
    Location:180302
    alpha_DG_C; C-terminal domain of alpha dystroglycan
  6. NM_001276493.1NP_001263422.1  dystroglycan preproprotein

    See identical proteins and their annotated locations for NP_001263422.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same protein.
    Source sequence(s)
    AC168217, AK038702, AV085570, CB289895, CJ106897, U43512
    Consensus CDS
    CCDS23518.1
    UniProtKB/Swiss-Prot
    Q62165
    UniProtKB/TrEMBL
    Q544G5
    Conserved Domains (3) summary
    pfam05454
    Location:604893
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    cd11303
    Location:60161
    Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
    cd11305
    Location:180302
    alpha_DG_C; C-terminal domain of alpha dystroglycan
  7. NM_010017.4NP_034147.1  dystroglycan preproprotein

    See identical proteins and their annotated locations for NP_034147.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-8 encode the same protein.
    Source sequence(s)
    AC168217, AK038702, AV085570, CB289895, U43512
    Consensus CDS
    CCDS23518.1
    UniProtKB/Swiss-Prot
    Q62165
    UniProtKB/TrEMBL
    Q544G5
    Related
    ENSMUSP00000130626, OTTMUSP00000069234, ENSMUST00000171412, OTTMUST00000128732
    Conserved Domains (3) summary
    pfam05454
    Location:604893
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    cd11303
    Location:60161
    Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
    cd11305
    Location:180302
    alpha_DG_C; C-terminal domain of alpha dystroglycan

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p3 C57BL/6J

    Range
    108204861..108263958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511636.1XP_006511699.1  

    See identical proteins and their annotated locations for XP_006511699.1

    UniProtKB/Swiss-Prot
    Q62165
    UniProtKB/TrEMBL
    Q544G5
    Conserved Domains (3) summary
    pfam05454
    Location:604893
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    cd11303
    Location:60161
    Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
    cd11305
    Location:180302
    alpha_DG_C; C-terminal domain of alpha dystroglycan

Alternate Mm_Celera

Genomic

  1. AC_000031.1 Alternate Mm_Celera

    Range
    107813482..107872794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001276494.1: Suppressed sequence

    Description
    NM_001276494.1: This RefSeq was removed because currently there is insufficient support for the transcript.