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    Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 [ Mus musculus (house mouse) ]

    Gene ID: 13113, updated on 18-May-2013
    Official Symbol
    Cyp3a13provided by MGI
    Official Full Name
    cytochrome P450, family 3, subfamily a, polypeptide 13provided by MGI
    Primary source
    MGI:88610
    See related
    Ensembl:ENSMUSG00000029727; Vega:OTTMUSG00000022877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IIIAm2
    Location :
    5 G2; 5 76.89 cM
    Sequence :
    Chromosome: 5; NC_000071.6 (137892933..137921619, complement)
    See Cyp3a13 in Epigenomics, MapViewer

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene paired immunoglobin-like type 2 receptor beta 2 Neighboring gene predicted gene 3103 Neighboring gene ZW10 interactor pseudogene Neighboring gene gap junction protein, gamma 3

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans. Kazuki Y, et al. Hum Mol Genet, 2013 Feb 1. PMID 23125282.
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750.
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068.
    4. Cytochrome P-450 3A13 and endothelin jointly mediate ductus arteriosus constriction to oxygen in mice. Baragatti B, et al. Am J Physiol Heart Circ Physiol, 2011 Mar. PMID 21193583.
    5. Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity. van Waterschoot RA, et al. Cancer Res, 2009 Dec 1. PMID 19920203.

    See all (27) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Oxygen acts primarily through the complex CYP3A13 (sensor)/endothelin-1 (effector) and, in an accessory way, directly onto endothelin-1. However, even without CYP3A13, the ductus arteriosus may close postnatally thanks to the contribution of ET-1.
      Title: Cytochrome P-450 3A13 and endothelin jointly mediate ductus arteriosus constriction to oxygen in mice.
    2. Genomic structure and regulation of CYP3a13.
      Title: Genomic characterization and regulation of CYP3a13: role of xenobiotics and nuclear receptors.
    Submit: New GeneRIF Correction
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    aromatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    electron carrier activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    cytochrome P450 3A13
    Names
    cytochrome P450 3A13
    CYPIIIA13
    cytochrome P450, steroid inducible 3a13
    NP_031845.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007819.4 → NP_031845.1  cytochrome P450 3A13

      Status: VALIDATED

      Source sequence(s)
      AK136494, AK149572
      Consensus CDS
      CCDS19781.1
      UniProtKB/TrEMBL
      Q3UW87
      UniProtKB/Swiss-Prot
      Q64464
      Related
      ENSMUSP00000031741, OTTMUSP00000026286, ENSMUST00000031741, OTTMUST00000055012
      Conserved Domains (2) summary
      COG2124
      Location:64 – 496
      Blast Score: 383
      CypX; Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]
      pfam00067
      Location:51 – 493
      Blast Score: 905
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p1 C57BL/6J

      Range
      137892933..137921619, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000027.1 Alternate Mm_Celera

      Range
      134879058..134907700, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01050068.1 None
    genomic AAHY01050069.1 None
    genomic AC125212.3 (141475..170159) None
    genomic AY823670.1 AAX39491.1 129/Sv
    genomic CH466529.2 EDL19227.1 mixed
    mRNA AK136494.1 BAE23008.1 C57BL/6J
    mRNA AK136529.1 BAE23029.1 C57BL/6J
    mRNA AK149572.1 BAE28966.1 C57BL/6J
    mRNA BC046592.1 AAH46592.1
    mRNA X63023.1 CAA44754.1 DDY
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64464.1 GenPept UniProtKB/Swiss-Prot:Q64464

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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