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Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 13076, updated on 28-May-2016
Official Symbol
Cyp1a1provided by MGI
Official Full Name
cytochrome P450, family 1, subfamily a, polypeptide 1provided by MGI
Primary source
MGI:MGI:88588
See related
Ensembl:ENSMUSG00000032315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AHH; AHRR; CP11; Cyp1a2; P450-1
Orthologs
Location:
9 B; 9 31.34 cM
Exon count:
8
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 9 NC_000075.6 (57687928..57703824)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (57535735..57551629)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene c-src tyrosine kinase Neighboring gene cytochrome P450, family 1, subfamily a, polypeptide 2 Neighboring gene enhancer of mRNA decapping 3 Neighboring gene CDC-like kinase 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
aromatase activity IEA
Inferred from Electronic Annotation
more info
 
catalytic activity ISO
Inferred from Sequence Orthology
more info
 
demethylase activity ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
flavonoid 3'-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity, acting on diphenols and related substances as donors ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IDA
Inferred from Direct Assay
more info
PubMed 
steroid hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
vitamin D 24-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
9-cis-retinoic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
amine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
PubMed 
coumarin metabolic process ISO
Inferred from Sequence Orthology
more info
 
dibenzo-p-dioxin catabolic process ISO
Inferred from Sequence Orthology
more info
 
NOT dibenzo-p-dioxin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
drug metabolic process ISO
Inferred from Sequence Orthology
more info
 
flavonoid metabolic process ISO
Inferred from Sequence Orthology
more info
 
heterocycle metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
hydrogen peroxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
insecticide metabolic process ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process ISO
Inferred from Sequence Orthology
more info
 
porphyrin-containing compound metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
response to toxic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
toxin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
cytochrome P450 1A1
Names
CYPIA1
aromatic compound inducible
cytochrome P450 family 1 subfamily a polypeptide 2
cytochrome P450 subfamily I, polypeptide 1
cytochrome P450, 1a1, aromatic compound inducible
cytochrome P450-P1
NP_001129531.1
NP_034122.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136059.2NP_001129531.1  cytochrome P450 1A1

    See identical proteins and their annotated locations for NP_001129531.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' non-coding exon compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AW110759, Y00071
    Consensus CDS
    CCDS23230.1
    UniProtKB/Swiss-Prot
    P00184
    UniProtKB/TrEMBL
    Q05A20
    Related
    ENSMUSP00000034865, ENSMUST00000034865
    Conserved Domains (1) summary
    pfam00067
    Location:44503
    p450; Cytochrome P450
  2. NM_009992.4NP_034122.1  cytochrome P450 1A1

    See identical proteins and their annotated locations for NP_034122.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK005000, AW110759
    Consensus CDS
    CCDS23230.1
    UniProtKB/Swiss-Prot
    P00184
    UniProtKB/TrEMBL
    Q05A20
    Conserved Domains (1) summary
    pfam00067
    Location:44503
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p3 C57BL/6J

    Range
    57687928..57703824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510810.2XP_006510873.1  

    See identical proteins and their annotated locations for XP_006510873.1

    UniProtKB/Swiss-Prot
    P00184
    UniProtKB/TrEMBL
    Q05A20
    Conserved Domains (1) summary
    pfam00067
    Location:44503
    p450; Cytochrome P450

Alternate Mm_Celera

Genomic

  1. AC_000031.1 Alternate Mm_Celera

    Range
    85889317..85895530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)