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Cyba cytochrome b-245, alpha polypeptide [ Mus musculus (house mouse) ]

Gene ID: 13057, updated on 8-May-2016
Official Symbol
Cybaprovided by MGI
Official Full Name
cytochrome b-245, alpha polypeptideprovided by MGI
Primary source
MGI:MGI:1316658
See related
Ensembl:ENSMUSG00000006519
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
b558; nmf333; p22phox; p22-phox
Orthologs
Location:
8; 8 E1
Exon count:
6
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 8 NC_000074.6 (122424771..122432965, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (124948671..124956840, complement)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH-type containing 18 Neighboring gene interleukin 17C Neighboring gene RIKEN cDNA 9330133O14 gene Neighboring gene mevalonate (diphospho) decarboxylase Neighboring gene predicted gene, 20735

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Chemically induced (ENU) (1) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
electron carrier activity ISO
Inferred from Sequence Orthology
more info
 
heme binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
superoxide-generating NADPH oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to superoxide-generating NADPH oxidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular response to organic substance ISO
Inferred from Sequence Orthology
more info
 
cytochrome complex assembly ISO
Inferred from Sequence Orthology
more info
 
hydrogen peroxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
inflammatory response ISO
Inferred from Sequence Orthology
more info
 
innate immune response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glomerular filtration by angiotensin ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NAD(P)H oxidase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mucus secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of reactive oxygen species biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of toll-like receptor 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
regulation of release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
respiratory burst ISO
Inferred from Sequence Orthology
more info
 
smooth muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
superoxide anion generation IBA
Inferred from Biological aspect of Ancestor
more info
 
superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
superoxide metabolic process ISO
Inferred from Sequence Orthology
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
NADPH oxidase complex IDA
Inferred from Direct Assay
more info
PubMed 
NADPH oxidase complex ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with NADPH oxidase complex ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with perinuclear endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
stress fiber ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
cytochrome b-245 light chain
Names
cytochrome b(558) alpha chain
cytochrome b558 subunit alpha
cytochrome beta-558
neutrophil cytochrome b 22 kDa polypeptide
p22 phagocyte B-cytochrome
p22 phox
superoxide-generating NADPH oxidase light chain subunit

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301284.1NP_001288213.1  cytochrome b-245 light chain isoform 2

    See identical proteins and their annotated locations for NP_001288213.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region compared to variant . The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK018713, AL591003, BC060635
    UniProtKB/Swiss-Prot
    Q61462
    Conserved Domains (1) summary
    pfam05038
    Location:2164
    Cytochrom_B558a; Cytochrome Cytochrome b558 alpha-subunit
  2. NM_007806.3NP_031832.2  cytochrome b-245 light chain isoform 1

    See identical proteins and their annotated locations for NP_031832.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK152414, BY005999, CF738398
    Consensus CDS
    CCDS22737.1
    UniProtKB/Swiss-Prot
    Q61462
    UniProtKB/TrEMBL
    B3VQI8
    Related
    ENSMUSP00000017604, ENSMUST00000017604
    Conserved Domains (1) summary
    pfam05038
    Location:2192
    Cytochrom_B558a; Cytochrome Cytochrome b558 alpha-subunit

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p3 C57BL/6J

    Range
    122424771..122432965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248301.1XP_011246603.1  

    Conserved Domains (1) summary
    pfam05038
    Location:2165
    Cytochrom_B558a; Cytochrome Cytochrome b558 alpha-subunit

Alternate Mm_Celera

Genomic

  1. AC_000030.1 Alternate Mm_Celera

    Range
    126653882..126662049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)