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UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) [ Homo sapiens (human) ]

Gene ID: 130507, updated on 8-May-2016
Official Symbol
UBR3provided by HGNC
Official Full Name
ubiquitin protein ligase E3 component n-recognin 3 (putative)provided by HGNC
Primary source
HGNC:HGNC:30467
See related
Ensembl:ENSG00000144357 HPRD:15887; MIM:613831; Vega:OTTHUMG00000132229
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF650
Orthologs
Location:
2q31.1
Exon count:
43
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (169827470..170084131)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (170684010..170940641)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene cytochrome b5 type A (microsomal) pseudogene 2 Neighboring gene methyltransferase like 5 Neighboring gene Sjogren syndrome antigen B Neighboring gene NSA2 ribosome biogenesis homolog (S. cerevisiae) pseudogene Neighboring gene uncharacterized LOC105373735 Neighboring gene myosin IIIB Neighboring gene uncharacterized LOC101929753

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr The interaction of Vpr with DDB1 facilitates the formation of complexes containing Cul4A-Roc1 E3 ubiquitin ligase. The association of Vpr with DDB1-containing E3 ligase mediates the degradation of UNG2 and SMUG1 PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ37422, KIAA2024, MGC126489, DKFZp434P117, DKFZp686N10185

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
embryo development ISS
Inferred from Sequence or Structural Similarity
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
olfactory behavior IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
sensory perception of smell ISS
Inferred from Sequence or Structural Similarity
more info
 
suckling behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin-dependent protein catabolic process via the N-end rule pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
E3 ubiquitin-protein ligase UBR3
Names
N-recognin-3
ubiquitin-protein ligase E3-alpha-3
ubiquitin-protein ligase E3-alpha-III
zinc finger protein 650
NP_742067.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172070.3NP_742067.3  E3 ubiquitin-protein ligase UBR3

    See identical proteins and their annotated locations for NP_742067.3

    Status: VALIDATED

    Source sequence(s)
    AC009967, AI142128, BC044060, BC113010, BF446017, BU158552, BU686724, BX281113, BX494687, DA108743, DA234864, DA301129, DA352029, DN831941, DR731153
    Consensus CDS
    CCDS2238.2
    UniProtKB/Swiss-Prot
    Q6ZT12
    Related
    ENSP00000396068, ENST00000418381
    Conserved Domains (1) summary
    pfam02207
    Location:119188
    zf-UBR; Putative zinc finger in N-recognin (UBR box)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    169827470..170084131
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510604.1XP_011508906.1  

    Conserved Domains (1) summary
    pfam02207
    Location:119188
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
  2. XM_006712268.2XP_006712331.1  

    Conserved Domains (1) summary
    pfam02207
    Location:119188
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
  3. XM_005246299.3XP_005246356.1  

    Conserved Domains (1) summary
    pfam02207
    Location:119188
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
  4. XM_005246300.3XP_005246357.1  

    Conserved Domains (1) summary
    pfam02207
    Location:119188
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
  5. XM_006712269.2XP_006712332.1  

    Conserved Domains (1) summary
    pfam02207
    Location:119188
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
  6. XM_006712270.2XP_006712333.2  

    Conserved Domains (1) summary
    pfam02207
    Location:119188
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
  7. XM_006712271.2XP_006712334.1  

    Conserved Domains (1) summary
    pfam02207
    Location:119188
    zf-UBR; Putative zinc finger in N-recognin (UBR box)

RNA

  1. XR_922842.1 RNA Sequence

  2. XR_922841.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    170689889..170947009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)