UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) [Homo sapiens] - Gene

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Summary

Official Symbol: UBR3provided by HGNC
Official Full Name: ubiquitin protein ligase E3 component n-recognin 3 (putative)provided by HGNC
Primary source: HGNC:30467
See related: Ensembl:ENSG00000144357; HPRD:15887; MIM:613831; Vega:OTTHUMG00000132229
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZNF650; FLJ37422; KIAA2024; MGC126489; DKFZp434P117; DKFZp686N10185

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Genomic context

Location :: 2q31.1

Sequence :: Chromosome: 2; NC_000002.11 (170684018..170940641)

See UBR3 in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The human E3 ubiquitin ligase UBR3 has a major activity that polyubiquitylates APE1 at multiple lysine residues clustered on the N-terminal tail.
Title: Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability.
Observational study of gene-disease association. (HuGE Navigator)
Title: Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:126237	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:126237	BioGRID:113167	UBE2A	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:126237	BioGRID:113168	UBE2B	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:126237	BioGRID:122419	UBE2Z	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
ligase activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
ubiquitin-protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
embryo development	ISS Inferred from Sequence or Structural Similarity more info
in utero embryonic development	IEA Inferred from Electronic Annotation more info
olfactory behavior	IEA Inferred from Electronic Annotation more info
protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
sensory perception of smell	ISS Inferred from Sequence or Structural Similarity more info
suckling behavior	ISS Inferred from Sequence or Structural Similarity more info
ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: E3 ubiquitin-protein ligase UBR3

Names: E3 ubiquitin-protein ligase UBR3; N-recognin-3; zinc finger protein 650; ubiquitin-protein ligase E3-alpha-3; ubiquitin-protein ligase E3-alpha-III

NP_742067.3

EC 6.3.2.-

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172070.3 → NP_742067.3 E3 ubiquitin-protein ligase UBR3

Status: VALIDATED

Source sequence(s)

AC009967, AI142128, BC044060, BC113010, BF446017, BU158552, BU686724, BX281113, BX494687, DA108743, DA234864, DA301129, DA352029, DN831941, DR731153

Consensus CDS

CCDS2238.2

UniProtKB/Swiss-Prot

Q6ZT12

Related

ENSP00000396068, ENST00000418381

Conserved Domains (2) summary

smart00396
Location:119 – 188
Blast Score: 210

ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway

pfam02207
Location:119 – 188
Blast Score: 242

zf-UBR; Putative zinc finger in N-recognin (UBR box)

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

170684018..170940641

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

162572017..162828315

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC009967.8 (125688..174205)	None
genomic	AC079151.4	None
genomic	AC092641.2	AAY14890.1
genomic	CH471058.2	EAX11248.1
		EAX11249.1
		EAX11250.1
mRNA	AB095944.1	BAC23120.1
mRNA	AI142128.1	None
mRNA	AK094741.1	None
mRNA	AK126998.1	BAC86783.1
mRNA	AK127553.1	BAC87032.1
mRNA	AK128490.1	BAC87462.1
mRNA	AK303062.1	BAG64179.1
mRNA	AL834144.1	CAD38857.1
mRNA	BC044060.1	None
mRNA	BC044594.1	None
mRNA	BC113010.2	None
mRNA	BF446017.1	None
mRNA	BU158552.1	None
mRNA	BU686724.1	None
mRNA	BX281113.1	None
mRNA	BX494687.1	None
mRNA	BX649036.1	None
mRNA	CR749469.1	CAH18299.1
mRNA	DA108743.1	None
mRNA	DA234864.1	None
mRNA	DA301129.1	None
mRNA	DA352029.1	None
mRNA	DN831941.1	None
mRNA	DR731153.1	None