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Ctbp1 C-terminal binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 13016, updated on 8-May-2016
Official Symbol
Ctbp1provided by MGI
Official Full Name
C-terminal binding protein 1provided by MGI
Primary source
MGI:MGI:1201685
See related
Ensembl:ENSMUSG00000037373 Vega:OTTMUSG00000055360
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BARS; D4S115h; D5H4S115; D5H4S115E; CtBP3/BARS
Orthologs
Location:
5 B1; 5 17.52 cM
Exon count:
10
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (33247723..33275004, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (33590372..33617618, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 (sodium/glucose cotransporter), member 1 Neighboring gene spondin 2, extracellular matrix protein Neighboring gene predicted gene 20465 Neighboring gene macrophage erythroblast attacher

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
(R)-2-hydroxyglutarate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
(R)-2-hydroxyisocaproate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
2-hydroxytetrahydrofuran dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
3-hydroxymenthone dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
3-ketoglucose-reductase activity IEA
Inferred from Electronic Annotation
more info
 
5-exo-hydroxycamphor dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity IEA
Inferred from Electronic Annotation
more info
 
D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 
D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 
D-xylose:NADP reductase activity IEA
Inferred from Electronic Annotation
more info
 
L-arabinose 1-dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 
L-arabinose:NADP reductase activity IEA
Inferred from Electronic Annotation
more info
 
L-xylulose reductase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
 
NAD binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
acetoin dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
aldo-keto reductase (NADP) activity IEA
Inferred from Electronic Annotation
more info
 
dihydrotestosterone 17-beta-dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
epoxide dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
gluconate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
isocitrate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
mevaldate reductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
phenylcoumaran benzylic ether reductase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
repressing transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
steroid dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
steroid dehydrogenase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
 
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription factor activity, sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
very long-chain-3-hydroxyacyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of histone H4 acetylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of histone acetylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter by histone modification ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of histone deacetylation ISO
Inferred from Sequence Orthology
more info
 
regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
white fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
transcriptional repressor complex IDA
Inferred from Direct Assay
more info
PubMed 
transcriptional repressor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
C-terminal-binding protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198859.1NP_001185788.1  C-terminal-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001185788.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region compared to variant 3. It encodes a shorter isoform (1) compared to isoform 3.
    Source sequence(s)
    AJ010483, BE991938, CJ163412
    UniProtKB/Swiss-Prot
    O88712
    Conserved Domains (2) summary
    COG0111
    Location:55354
    SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]
    cd05299
    Location:28346
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  2. NM_001198860.1NP_001185789.1  C-terminal-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001185789.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' region, initiates translation at an alternate start codon, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. It encodes a shorter isoform (2) with a distinct N-terminus compared to isoform 3.
    Source sequence(s)
    AJ010483, BE991938, CJ163412
    Consensus CDS
    CCDS80256.1
    UniProtKB/Swiss-Prot
    O88712
    UniProtKB/TrEMBL
    A0A0J9YU62
    Related
    ENSMUSP00000144024, OTTMUSP00000072236, ENSMUST00000202868, OTTMUST00000137058
    Conserved Domains (2) summary
    COG0111
    Location:44343
    SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  3. NM_001198861.1NP_001185790.1  C-terminal-binding protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001185790.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 5' region and initiates translation at an alternate start codon, compared to variant 3. It encodes a shorter isoform (4) with a distinct N-terminus compared to isoform 3.
    Source sequence(s)
    AK133816, BE991938, CJ163412
    UniProtKB/Swiss-Prot
    O88712
    Conserved Domains (2) summary
    COG0111
    Location:44343
    SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  4. NM_001310535.1NP_001297464.1  C-terminal-binding protein 1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the 5' region and initiates translation at a downstream start codon, compared to variant 3. It encodes a shorter isoform (5) with a shorter N-terminus compared to isoform 3.
    Source sequence(s)
    AC115070
    Consensus CDS
    CCDS80255.1
    UniProtKB/Swiss-Prot
    O88712
    Conserved Domains (2) summary
    COG1052
    Location:7279
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05299
    Location:7272
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  5. NM_013502.3NP_038530.1  C-terminal-binding protein 1 isoform 3

    See identical proteins and their annotated locations for NP_038530.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AK133816, BE991938, CJ163412
    Consensus CDS
    CCDS19201.1
    UniProtKB/Swiss-Prot
    O88712
    Related
    ENSMUSP00000078682, OTTMUSP00000072233, ENSMUST00000079746, OTTMUST00000137055
    Conserved Domains (2) summary
    COG0111
    Location:55354
    SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]
    cd05299
    Location:28346
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

    Range
    33247723..33275004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503710.1XP_006503773.1  

    Related
    ENSMUSP00000144554, OTTMUSP00000072235, ENSMUST00000201575, OTTMUST00000137057
    Conserved Domains (2) summary
    COG1052
    Location:7279
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05299
    Location:7272
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

Alternate Mm_Celera

Genomic

  1. AC_000027.1 Alternate Mm_Celera

    Range
    30726910..30748817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)