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AADAC arylacetamide deacetylase [ Homo sapiens (human) ]

Gene ID: 13, updated on 7-May-2016
Official Symbol
AADACprovided by HGNC
Official Full Name
arylacetamide deacetylaseprovided by HGNC
Primary source
HGNC:HGNC:17
See related
Ensembl:ENSG00000114771 HPRD:02640; MIM:600338; Vega:OTTHUMG00000159876
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAC; CES5A1
Summary
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]
Orthologs
Location:
3q25.1
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (151814025..151828488)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (151531769..151546276)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene AADACL2 antisense RNA 1 Neighboring gene arylacetamide deacetylase pseudogene 1 Neighboring gene uncharacterized LOC105374160 Neighboring gene succinate receptor 1 Neighboring gene uncharacterized LOC105374159

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
NHGRI GWA Catalog
  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Phase 1 - Functionalization of compounds, organism-specific biosystem (from REACTOME)
    Phase 1 - Functionalization of compounds, organism-specific biosystemPhase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conj...

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
catalytic activity TAS
Traceable Author Statement
more info
PubMed 
deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
deacetylase activity TAS
Traceable Author Statement
more info
 
lipase activity TAS
Traceable Author Statement
more info
PubMed 
serine hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
triglyceride lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
positive regulation of triglyceride catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
arylacetamide deacetylase
Names
arylacetamide deacetylase (esterase)
NP_001077.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086.2NP_001077.2  arylacetamide deacetylase

    See identical proteins and their annotated locations for NP_001077.2

    Status: REVIEWED

    Source sequence(s)
    AV705031, BC032309, L32179
    Consensus CDS
    CCDS33877.1
    UniProtKB/Swiss-Prot
    P22760
    Related
    ENSP00000232892, OTTHUMP00000216826, ENST00000232892, OTTHUMT00000357883
    Conserved Domains (2) summary
    pfam07859
    Location:107374
    Abhydrolase_3; alpha/beta hydrolase fold
    cl21494
    Location:72204
    Esterase_lipase; Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    151814025..151828488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247104.3XP_005247161.1  

    Conserved Domains (2) summary
    pfam07859
    Location:90357
    Abhydrolase_3; alpha/beta hydrolase fold
    cl21494
    Location:55187
    Esterase_lipase; Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    151494887..151509289
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)