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    Csf2 colony stimulating factor 2 (granulocyte-macrophage) [ Mus musculus ]

    Gene ID: 12981, updated on 5-Feb-2012
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    Summary

    Official Symbol
    Csf2provided by MGI
    Official Full Name
    colony stimulating factor 2 (granulocyte-macrophage)provided by MGI
    Primary source
    MGI:1339752
    Locus tag
    RP23-309E16.1
    See related
    Ensembl:ENSMUSG00000018916; Vega:OTTMUSG00000005663
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Csfgm; GMCSF; Gm-CSf; MGI-IGM
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    Genomic context

    Location :
    11 B1.3; 11 29.5 cM
    Sequence :
    Chromosome: 11; NC_000077.5 (54060772..54063401, complement)
    See Csf2 in Epigenomics, MapViewer

    Chromosome 11 - NC_000077.5Genomic Context describing neighboring genes Neighboring gene Sdccag3 pseudogene Neighboring gene acyl-CoA-binding protein ACBP pseudogene Neighboring gene interleukin 3 Neighboring gene acyl-CoA synthetase long-chain family member 6 Neighboring gene predicted gene 12224

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. GM-CSF-induced regulatory T cells selectively inhibit anti-acetylcholine receptor-specific immune responses in experimental myasthenia gravis. Sheng JR, et al. J Neuroimmunol, 2011 Dec 15. PMID 22099723.
    2. Mast cells condition dendritic cells to mediate allograft tolerance. de Vries VC, et al. Immunity, 2011 Oct 28. PMID 22035846.
    3. Lentivirus-ABCG1 instillation reduces lipid accumulation and improves lung compliance in GM-CSF knock-out mice. Malur A, et al. Biochem Biophys Res Commun, 2011 Nov 18. PMID 22033401.
    4. Local delivery of GM-CSF protects mice from lethal pneumococcal pneumonia. Steinwede K, et al. J Immunol, 2011 Nov 15. PMID 22003204.
    5. In situ proliferation and differentiation of macrophages in dental pulp. Iwasaki Y, et al. Cell Tissue Res, 2011 Oct. PMID 21922246.

    See all (326) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. enhances differentiation of microglia from bone marrow stem cells
      Title: Differentiation of mouse bone marrow derived stem cells toward microglia-like cells.
    2. Recombinant mouse GM-CSF in the lung rescues mice from lethal pneumococcal pneumonia via adenoviral-mediated gene transfer of GM-CSF either 14 or even 28 days before infection.
      Title: Local delivery of GM-CSF protects mice from lethal pneumococcal pneumonia.
    3. increases cross-presentation and CD103 expression by mouse CD8+ spleen dendritic cells
      Title: GM-CSF increases cross-presentation and CD103 expression by mouse CD8⁺ spleen dendritic cells.
    4. functional activities of GM-CSF-stimulated mouse myeloid-derived dendritic cells at late differentiation stage.
      Title: Interleukin-4 enhances trafficking and functional activities of GM-CSF-stimulated mouse myeloid-derived dendritic cells at late differentiation stage.
    5. Hypoxia-inducible factor-2alpha regulates GM-CSF-derived soluble vascular endothelial growth factor receptor 1 production from macrophages and inhibits tumor growth and angiogenesis.
      Title: Hypoxia-inducible factor-2α regulates GM-CSF-derived soluble vascular endothelial growth factor receptor 1 production from macrophages and inhibits tumor growth and angiogenesis.
    6. GM-CSF was shown to induce the expression of Bcl-2 and Bcl-xl via Janus tyrosine kinase and via signal transducers and activators of transcription 5 (STAT5) and STAT3, but only JAK/STAT5-Bcl-2 was responsible for anti-apoptotic activity.
      Title: Granulocyte macrophage-colony stimulating factor shows anti-apoptotic activity in neural progenitor cells via JAK/STAT5-Bcl-2 pathway.
    7. Data show that GM-CSF-secretion is dependent on RORgammat expression.
      Title: RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation.
    8. IL-23 induced a positive feedback loop whereby GM-CSF secreted by T(H)17 cells stimulated the production of IL-23 by antigen-presenting cells.
      Title: The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.
    9. NF-kappaB1 serves a critical role in the production of GM-CSF by activated CD4 T cells during inflammatory responses
      Title: Differentiation of inflammatory dendritic cells is mediated by NF-κB1-dependent GM-CSF production in CD4 T cells.
    10. SP-D inhibits pulmonary inflammation and migration of peripheral monocyte/macrophages into the lung through GM-CSF-dependent pathways during indirect lung injury
      Title: Surfactant protein D deficiency increases lung injury during endotoxemia.
    Submit: New GeneRIF Correction See all (94)
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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
      Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokines and Inflammatory Response (BioCarta), organism-specific biosystem (from WikiPathways)
      Cytokines and Inflammatory Response (BioCarta), organism-specific biosystemSee BioCarta version: http://www.biocarta.com/pathfiles/h_inflamPathway.asp
    • Fc epsilon RI signaling pathway, organism-specific biosystem (from KEGG)
      Fc epsilon RI signaling pathway, organism-specific biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
    • Fc epsilon RI signaling pathway, conserved biosystem (from KEGG)
      Fc epsilon RI signaling pathway, conserved biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Interleukin receptor SHC signaling, organism-specific biosystem (from REACTOME)
      Interleukin receptor SHC signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-2 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
      Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
      Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Rheumatoid arthritis, conserved biosystem (from KEGG)
      Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Salmonella infection, organism-specific biosystem (from KEGG)
      Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Salmonella infection, conserved biosystem (from KEGG)
      Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer

    Clone Names

    • MGC151255, MGC151257

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytokine activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytokine activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    granulocyte macrophage colony-stimulating factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    embryonic placenta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    epithelial fluid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    macrophage activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    myeloid dendritic cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of cytolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of interleukin-23 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of macrophage derived foam cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of podosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of survival gene product expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of tyrosine phosphorylation of Stat5 protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
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    General protein information

    Preferred Names
    granulocyte-macrophage colony-stimulating factor
    Names
    granulocyte-macrophage colony-stimulating factor
    CSF
    put. GM-CSF
    colony-stimulating factor
    granulocyte-macrophage colony stimulating factor 2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009969.4 → NP_034099.2  granulocyte-macrophage colony-stimulating factor precursor

      Status: PROVISIONAL

      Source sequence(s)
      AL596103
      Consensus CDS
      CCDS24692.1
      UniProtKB/Swiss-Prot
      P01587
      UniProtKB/TrEMBL
      Q5SX78
      Related
      ENSMUSP00000019060, OTTMUSP00000005830, ENSMUST00000019060, OTTMUST00000012596
      Conserved Domains (1) summary
      cd00040
      Location:18 – 135
      Blast Score: 419
      CSF2; Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a member of the large family of polypeptide growth factors called cytokines. It stimulates a wide variety of hematopoietic and nonhematopoietic cell types via binding to members of the cytokine ...

    RefSeqs of Annotated Genomes: Build 37.2

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference MGSCv37 C57BL/6J

    Genomic

    1. NC_000077.5 Reference MGSCv37 C57BL/6J

      Range
      54060772..54063401, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000033.1 Alternate Mm_Celera

      Range
      58835805..58838455, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AL596103.22 CAI25072.1
    genomic CH466575.2 EDL33540.1 mixed
    genomic X03020.1 CAA26821.1
    mRNA AK053196.1 BAE20692.1 C57BL/6J
    mRNA BC116878.1 AAI16879.1
    mRNA BC116880.1 AAI16881.1
    mRNA EU366957.1 ABY66391.1 C57BL/6
    mRNA M11848.1 AAA37483.1
    mRNA X02333.1 CAA26193.1 BALB/c
    mRNA X03019.1 CAA26820.1
    mRNA X03221.1 None
    mRNA X05906.1 CAA29336.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P01587.1 GenPept UniProtKB/Swiss-Prot:P01587
    Q14AD9 GenPept UniProtKB/TrEMBL:Q14AD9
    Q5SX78 GenPept UniProtKB/TrEMBL:Q5SX78
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

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