Csf2 colony stimulating factor 2 (granulocyte-macrophage) [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Csf2provided by MGI
Official Full Name: colony stimulating factor 2 (granulocyte-macrophage)provided by MGI
Primary source: MGI:1339752
Locus tag: RP23-309E16.1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Csfgm; GMCSF; Gm-CSf; MGI-IGM

Genomic context

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Location :: 11 B1.3; 11 32.13 cM

Sequence :: Chromosome: 11; NC_000077.6 (54247270..54249899, complement)

See Csf2 in Epigenomics, MapViewer

Chromosome 11 - NC_000077.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Nuclear activation of c-Rel regulates the initiation of GM-CSF and IL-2 gene activation in response to T cell activation and the termination of these gene responses following the removal of the activating signal.
Title: Depletion of c-Rel from cytokine gene promoters is required for chromatin reassembly and termination of gene responses to T cell activation.
Endogenous epithelial cell-produced GM-CSF has a novel nonredundant role in facilitating epithelial cell proliferation and ulcer healing in response to injury of the colon crypt epithelium.
Title: GM-CSF produced by nonhematopoietic cells is required for early epithelial cell proliferation and repair of injured colonic mucosa.
Allergic sensitization to HDM was abolished in vivo when IL-1alpha, GM-CSF, or IL-33 was neutralized.
Title: Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33.
IL-1R is needed for GM-CSF production after TCR- and cytokine-induced stimulation of immune cells. Inflammasome-derived IL-1beta is a critical regulator of GM-CSF production by T cells during priming. MyD88 promotes GM-CSF production in alphabeta & gammadelta T cells.
Title: Inflammasome-derived IL-1β regulates the production of GM-CSF by CD4(+) T cells and γδ T cells.
IL-27 is a key negative regulator of GM-CSF expression by T cells, which likely regulates inflammation in health and disease.
Title: Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.
in inflammation, GM-CSF can maintain the response by contributing to the prolonged extravasation of immature monocytes and neutrophils. A correlation has been observed between macrophage numbers and the severity of certain inflammatory conditions
Title: Control of macrophage lineage populations by CSF-1 receptor and GM-CSF in homeostasis and inflammation.
GM-CSF is a critical mediator of leukotriene B4 (LTB4)-enhanced PU.1 and dectin-1 expression required for fungi-protective host responses.
Title: Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis.
Csf-2 is important in vaccine-induced CD8(+) T cell immunity through the regulation of nonlymphoid tissue DC homeostasis rather than control of inflammatory DCs in vivo.
Title: GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells.
Data show that an oncogenic Kras-dependent upregulation of GM-CSF in mouse pancreatic ductal epithelial cells (PDECs).
Title: Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia.
Data suggest that tumor-derived GM-CSF is an important regulator of inflammation and immune suppression within the tumor microenvironment.
Title: Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer.

Submit: New GeneRIF Correction See all (124)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (2) 1 citation
Targeted (Reporter) (1) 1 citation
Targeted (knock-in) (1) 1 citation

Pathways from BioSystems

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Amoebiasis, organism-specific biosystem (from KEGG)
Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
Amoebiasis, conserved biosystem (from KEGG)
Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokines and Inflammatory Response (BioCarta), organism-specific biosystem (from WikiPathways)
Cytokines and Inflammatory Response (BioCarta), organism-specific biosystemSee BioCarta version: http://www.biocarta.com/pathfiles/h_inflamPathway.asp
Fc epsilon RI signaling pathway, organism-specific biosystem (from KEGG)
Fc epsilon RI signaling pathway, organism-specific biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
Fc epsilon RI signaling pathway, conserved biosystem (from KEGG)
Fc epsilon RI signaling pathway, conserved biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
HTLV-I infection, organism-specific biosystem (from KEGG)
HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
HTLV-I infection, conserved biosystem (from KEGG)
HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
Hematopoietic cell lineage, conserved biosystem (from KEGG)
Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Interleukin receptor SHC signaling, organism-specific biosystem (from REACTOME)
Interleukin receptor SHC signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
Interleukin-2 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Jak-STAT signaling pathway, conserved biosystem (from KEGG)
Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
Rheumatoid arthritis, organism-specific biosystem (from KEGG)
Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
Rheumatoid arthritis, conserved biosystem (from KEGG)
Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
Salmonella infection, organism-specific biosystem (from KEGG)
Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
Salmonella infection, conserved biosystem (from KEGG)
Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
Signaling by Interleukins, organism-specific biosystem (from REACTOME)
Signaling by Interleukins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
T cell receptor signaling pathway, conserved biosystem (from KEGG)
T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
Transcriptional misregulation in cancer, organism-specific biosystem
Transcriptional misregulation in cancer
Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
Transcriptional misregulation in cancer, conserved biosystem
Transcriptional misregulation in cancer

General gene information

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Markers

Csf2 (e-PCR), detects polymorphism
- UniSTS:532229

X03020 (e-PCR)
- UniSTS:125780

Csf2 (e-PCR), detects polymorphism
- UniSTS:141410

Csf2 (e-PCR), detects polymorphism
- UniSTS:141411

Csf2 (e-PCR), detects polymorphism
- UniSTS:141412

Csf2 (e-PCR), detects polymorphism
- UniSTS:265068

NoName (e-PCR)
- UniSTS:492509

PMC15548P2 (e-PCR)
- UniSTS:271340

Homology

Homologs of the Csf2 gene: The Csf2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
cytokine activity	IDA Inferred from Direct Assay more info	PubMed
cytokine activity	ISO Inferred from Sequence Orthology more info
granulocyte macrophage colony-stimulating factor receptor binding	IEA Inferred from Electronic Annotation more info
growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
dendritic cell differentiation	ISO Inferred from Sequence Orthology more info
embryonic placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
epithelial fluid transport	ISO Inferred from Sequence Orthology more info
immune response	IEA Inferred from Electronic Annotation more info
macrophage activation	ISO Inferred from Sequence Orthology more info
myeloid dendritic cell differentiation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of cytolysis	ISO Inferred from Sequence Orthology more info
positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
positive regulation of cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
positive regulation of interleukin-23 production	ISO Inferred from Sequence Orthology more info
positive regulation of macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
positive regulation of podosome assembly	ISO Inferred from Sequence Orthology more info
positive regulation of tyrosine phosphorylation of Stat5 protein	ISO Inferred from Sequence Orthology more info
regulation of cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed
extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: granulocyte-macrophage colony-stimulating factor

Names: granulocyte-macrophage colony-stimulating factor; CSF; put. GM-CSF; colony-stimulating factor; granulocyte-macrophage colony stimulating factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009969.4 → NP_034099.2 granulocyte-macrophage colony-stimulating factor precursor

Status: PROVISIONAL

Source sequence(s)

AL596103

Consensus CDS

CCDS24692.1

UniProtKB/Swiss-Prot

P01587

UniProtKB/TrEMBL

Q5SX78

Conserved Domains (1) summary

cd00040
Location:18 – 135
Blast Score: 419

CSF2; Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a member of the large family of polypeptide growth factors called cytokines. It stimulates a wide variety of hematopoietic and nonhematopoietic cell types via binding to members of the cytokine ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000077.6 Reference GRCm38.p1 C57BL/6J

Range

54247270..54249899, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000033.1 Alternate Mm_Celera

Range

58835805..58838455, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01093388.1 (35132..37782)	None
genomic	AL596103.22 (151688..154318)	None
genomic	CH466575.2	EDL33540.1	mixed
genomic	X03020.1	CAA26821.1
mRNA	AK053196.1	BAE20692.1	C57BL/6J
mRNA	BC116878.1	AAI16879.1
mRNA	BC116880.1	AAI16881.1
mRNA	EU366957.1	ABY66391.1	C57BL/6
mRNA	M11848.1	AAA37483.1
mRNA	X02333.1	CAA26193.1	BALB/c
mRNA	X03019.1	CAA26820.1
mRNA	X03221.1	None
mRNA	X05906.1	CAA29336.1