Csf1r colony stimulating factor 1 receptor [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Csf1rprovided by MGI
Official Full Name: colony stimulating factor 1 receptorprovided by MGI
Primary source: MGI:1339758
See related: Ensembl:ENSMUSG00000024621; Vega:OTTMUSG00000014918
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fms; CD115; Csfmr; Fim-2; CSF-1R; M-CSFR; M-CSF-R; AI323359

Genomic context

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Location :: 18 D; 18 34.41 cM

Sequence :: Chromosome: 18; NC_000084.6 (61105572..61131139)

See Csf1r in Epigenomics, MapViewer

Chromosome 18 - NC_000084.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

M-CSF binding to its receptor, c-Fms, results in increased c-Fms activation in Nf1(+/) (-) osteoclast progenitors, mediating multiple gain-in-functions through the downstream effectors Erk1/2 and p90RSK.
Title: c-Fms signaling mediates neurofibromatosis Type-1 osteoclast gain-in-functions.
Colony-stimulating factor 1 receptor signaling in injured neurons facilitates their protection and survival.
Title: Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival.
Differentiated signaling between IL-34 and CSF-1 is likely achieved by the relative thermodynamic independence of IL-34 versus negative cooperativity of CSF-1 at the CSF-1 receptor recognition sites.
Title: The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1.
CSF-1R signaling controls the development of the macrophage lineage at a relatively late stage under steady state conditions
Title: Control of macrophage lineage populations by CSF-1 receptor and GM-CSF in homeostasis and inflammation.
The expression of CSF-1R in neurons could be up-regulated by ischemic injury in the central nervous system.
Title: [The expressional alterations of CSF-1R after ischemic injury of cerebral cortex].
Study results provide a mechanistic explanation for the involvement of CSF-1 in glioblastoma progression and indicate that inhibition of CSF-1R signaling could provide a novel approach to limiting glioblastoma invasion
Title: Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling.
ablation of the Csf1r gene in Nestin-positive neural progenitors led to a smaller brain size, an expanded neural progenitor pool and elevated cellular apoptosis in cortical forebrain
Title: The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation.
Macrophage proliferation is regulated through CSF-1 receptor tyrosines 544, 559, and 807
Title: Macrophage proliferation is regulated through CSF-1 receptor tyrosines 544, 559, and 807.
p110delta-dependent translocation of exogenous CSF-1 to the nucleus-associated CSF-1Rs, correlating with a prominent role of p110delta in activation of the Rab5 GTPase, a key regulator of endocytic trafficking
Title: Functional CSF-1 receptors are located at the nuclear envelope and activated via the p110δ isoform of PI 3-kinase.
a structural and mechanistic consensus for the assembly of mouse CSF-1:CSF-1R complexes
Title: Extracellular complexes of the hematopoietic human and mouse CSF-1 receptor are driven by common assembly principles.

Submit: New GeneRIF Correction See all (48)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NC_000084.1	NP_035485.1	Sfpi1	BIND	PubMed	PU.1 interacts with the Fms intronic regulatory element (FIRE) genomic region of the CSF-1R gene .
NP_031805.1	NP_031645.1	Cbl	BIND	PubMed	CSF-1 receptor interacts with Cbl.
NP_031805.1	NP_001003908.1	Cltc	BIND	PubMed	CSF-1 receptor interacts with Clathrin.
NP_031805.1	NP_032189.1	Grb2	BIND	PubMed	Grb2 interacts with Csf1r. This interaction was modelled on a demonstrated interaction between an unspecified isoform of human Grb2 and mouse Csf1r.
NP_031805.1	NP_032189.1	Grb2	BIND	PubMed	CSF-1 receptor interacts with Grb2.
NP_031805.1	NP_112442.2	Hspa8	BIND	PubMed	CSF-1 receptor interacts with HSC73.
NP_031805.1	NP_034696.1	Inpp5d	BIND	PubMed	CSF-1 receptor interacts with SHIP.
NP_031805.1	NP_075633.1	Nono	BIND	PubMed	CSF-1 receptor interacts with NonO.
NP_031805.1	NP_035980.1	Nr0b2	BIND	PubMed	CSF-1 receptor interacts with Shp1.
NP_031805.1	AAC52847.1	Pik3r1	BIND	PubMed	CSF-1R interacts with p85. This interaction was modelled on a demonstrated interaction between mouse CSF-1R and bovine p85.
NP_031805.1	NP_035332.1	Ptpn11	BIND	PubMed	CSF-1 receptor interacts with Shp2.
NP_031805.1	NP_076092.1	Sfpq	BIND	PubMed	CSF-1 receptor interacts with PSF.
NP_031805.1	NP_033257.1	Sos1	BIND	PubMed	CSF-1 receptor interacts with Sos1.
NP_031805.1			BIND	PubMed	Tyrosine phosphorylated CSF-1R interacts with PI3K. This interaction was modelled on a demonstrated interaction between mouse CSF1-R and rat PI3K.
BioGRID:198928	BioGRID:198527	Cbl	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198928	BioGRID:198928	Csf1r	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198928	BioGRID:199267	Dok1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198928	BioGRID:199773	Fyn	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198928	BioGRID:200046	Grb2	BioGRID	PubMed	Co-fractionation
BioGRID:198928	BioGRID:204818	Nr0b2	BioGRID	PubMed	Co-fractionation
BioGRID:198928	BioGRID:202162	Pik3r1	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation
BioGRID:198928	BioGRID:203215	Shc1	BioGRID	PubMed	Co-fractionation
BioGRID:198928	BioGRID:198719	Socs1	BioGRID	PubMed	Two-hybrid
BioGRID:198928	BioGRID:203491	Src	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198928	BioGRID:208177	Stap1	BioGRID	PubMed	Two-hybrid
BioGRID:198928	BioGRID:203523	Stat3	BioGRID	PubMed	Co-fractionation
BioGRID:198928	BioGRID:223611	Thoc5	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:198928	BioGRID:207726	Tyk2	BioGRID	PubMed	Co-fractionation
BioGRID:198928	BioGRID:204403	Ubc	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Endocytosis, organism-specific biosystem (from KEGG)
Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Endocytosis, conserved biosystem (from KEGG)
Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
Hematopoietic cell lineage, conserved biosystem (from KEGG)
Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
Osteoclast differentiation, organism-specific biosystem (from KEGG)
Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
Osteoclast differentiation, conserved biosystem (from KEGG)
Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
Transcriptional misregulation in cancer, organism-specific biosystem
Transcriptional misregulation in cancer
Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
Transcriptional misregulation in cancer, conserved biosystem
Transcriptional misregulation in cancer
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

General gene information

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Markers

MARC_12115-12116:1004707389:1 (e-PCR)
- UniSTS:267343

NoName (e-PCR)
- UniSTS:224344

PMC186377P4 (e-PCR)
- UniSTS:271705

Csf1r (e-PCR), detects polymorphism
- UniSTS:256388

X06368 (e-PCR)
- UniSTS:181129

AI323359 (e-PCR)
- UniSTS:181130

CSF1R_1770 (e-PCR)
- UniSTS:277131

D18Mit140 (e-PCR), detects polymorphism
- UniSTS:128162

PMC219482P1 (e-PCR)
- UniSTS:272080

PMC219482P2 (e-PCR)
- UniSTS:272081

AI413166 (e-PCR)
- UniSTS:160747

Csf1r (e-PCR), detects polymorphism
- UniSTS:265215

Homology

Homologs of the Csf1r gene: The Csf1r gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
cytokine binding	IDA Inferred from Direct Assay more info	PubMed
cytokine binding	IPI Inferred from Physical Interaction more info	PubMed
cytokine binding	ISO Inferred from Sequence Orthology more info
kinase activity	IEA Inferred from Electronic Annotation more info
macrophage colony-stimulating factor receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
macrophage colony-stimulating factor receptor activity	ISO Inferred from Sequence Orthology more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
protein kinase activity	IEA Inferred from Electronic Annotation more info
protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
transferase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info
transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cell proliferation	ISO Inferred from Sequence Orthology more info
cell-cell junction maintenance	ISO Inferred from Sequence Orthology more info
cellular response to cytokine stimulus	IMP Inferred from Mutant Phenotype more info
cellular response to macrophage colony-stimulating factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to macrophage colony-stimulating factor stimulus	ISO Inferred from Sequence Orthology more info
cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
hemopoiesis	ISO Inferred from Sequence Orthology more info
inflammatory response	IEA Inferred from Electronic Annotation more info
innate immune response	IEA Inferred from Electronic Annotation more info
macrophage colony-stimulating factor signaling pathway	ISO Inferred from Sequence Orthology more info
osteoclast differentiation	IMP Inferred from Mutant Phenotype more info
peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
phosphatidylinositol metabolic process	IMP Inferred from Mutant Phenotype more info
phosphatidylinositol-mediated signaling	IMP Inferred from Mutant Phenotype more info
phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info
positive regulation of cell motility	ISO Inferred from Sequence Orthology more info
positive regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of chemokine secretion	ISO Inferred from Sequence Orthology more info
positive regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
positive regulation of protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info
positive regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
positive regulation of tyrosine phosphorylation of Stat3 protein	IMP Inferred from Mutant Phenotype more info	PubMed
protein autophosphorylation	IDA Inferred from Direct Assay more info
protein autophosphorylation	ISO Inferred from Sequence Orthology more info
protein phosphorylation	IEA Inferred from Electronic Annotation more info
regulation of actin cytoskeleton reorganization	IMP Inferred from Mutant Phenotype more info
regulation of bone resorption	ISO Inferred from Sequence Orthology more info
regulation of cell shape	IMP Inferred from Mutant Phenotype more info
regulation of cell shape	ISO Inferred from Sequence Orthology more info
ruffle organization	IMP Inferred from Mutant Phenotype more info
transmembrane receptor protein tyrosine kinase signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
cell surface	IDA Inferred from Direct Assay more info	PubMed
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: macrophage colony-stimulating factor 1 receptor

Names: macrophage colony-stimulating factor 1 receptor; c-fms; CSF-1-R; CSF-1 receptor; proto-oncogene fms; proto-oncogene c-Fms

NP_001032948.2

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037859.2 → NP_001032948.2 macrophage colony-stimulating factor 1 receptor precursor

Status: VALIDATED

Source sequence(s)

AK146069, BB738990, BC066863

Consensus CDS

CCDS29280.1

UniProtKB/Swiss-Prot

P09581

UniProtKB/TrEMBL

Q0P635

UniProtKB/TrEMBL

Q3UKC6

UniProtKB/TrEMBL

Q6NXV8

Related

ENSMUSP00000025523, OTTMUSP00000015851, ENSMUST00000025523, OTTMUST00000035435

Conserved Domains (7) summary

cd05106
Location:541 – 913
Blast Score: 2024

PTKc_CSF-1R; Catalytic domain of the Protein Tyrosine Kinase, Colony-Stimulating Factor-1 Receptor

cd00096
Location:220 – 292
Blast Score: 101

Ig; Immunoglobulin domain

cd04975
Location:299 – 398
Blast Score: 340

Ig4_SCFR_like; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR) and similar proteins

pfam07679
Location:203 – 295
Blast Score: 96

I-set; Immunoglobulin I-set domain

smart00409
Location:113 – 195
Blast Score: 102

IG; Immunoglobulin

smart00410
Location:28 – 101
Blast Score: 125

IG_like; Immunoglobulin like

pfam07714
Location:739 – 908
Blast Score: 713

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000084.6 Reference GRCm38.p1 C57BL/6J

Range

61105572..61131139

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000040.1 Alternate Mm_Celera

Range

62392678..62417929

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_007779.2: Suppressed sequence

Description

NM_007779.2: This RefSeq was permanently suppressed because currently insufficient support exists for the transcript and the protein.

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01139259.1	None
genomic	AAHY01139260.1 (49778..55433)	None
genomic	AC124448.4 (5664..31229)	None
genomic	AF290879.1	AAG38018.1
genomic	CH466528.2	EDL09784.1	mixed
		EDL09785.1	mixed
		EDL09786.1	mixed
genomic	S62219.1	AAP13932.1
mRNA	AK004947.1	BAB23691.1	C57BL/6J
mRNA	AK041299.1	None	C57BL/6J
mRNA	AK076215.1	None	C57BL/6J
mRNA	AK079247.1	BAC37587.1	C57BL/6J
mRNA	AK080326.1	None	C57BL/6J
mRNA	AK089498.1	BAE43398.1	C57BL/6J
mRNA	AK143545.1	BAE25430.1	C57BL/6J
mRNA	AK146069.1	BAE26875.1	C57BL/6J
mRNA	AK154128.1	BAE32393.1	NOD
mRNA	AK154556.1	BAE32675.1	NOD
mRNA	AK154653.1	BAE32744.1	NOD
mRNA	AK154699.1	None	NOD
mRNA	AK155488.1	None	NOD
mRNA	AK155498.1	None	NOD
mRNA	AK155565.1	None	NOD
mRNA	AK155576.1	BAE33332.1	NOD
mRNA	AK155640.1	BAE33360.1	C57BL/6J
mRNA	AK155654.1	BAE33369.1	C57BL/6J
mRNA	AK155858.1	None	C57BL/6J
mRNA	AK156550.1	None	NOD
mRNA	AK171241.1	BAE42334.1	NOD
mRNA	AK171386.1	None	C57BL/6J
mRNA	AK171543.1	BAE42517.1	C57BL/6J
mRNA	BB738990.1	None	C57BL/6J
mRNA	BC036343.1	AAH36343.1	FVB/N
mRNA	BC043054.1	AAH43054.1	C57BL/6
mRNA	BC050024.1	None
mRNA	BC066863.1	AAH66863.1	C57BL/6J
mRNA	X06368.1	CAA29666.1
mRNA	X68932.1	None	(C57B1/6xBALB/c)F1