TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa [Homo sapiens] - Gene

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Summary

Official Symbol: TAF8provided by HGNC
Official Full Name: TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDaprovided by HGNC
Primary source: HGNC:17300
See related: Ensembl:ENSG00000137413; HPRD:18167; MIM:609514; Vega:OTTHUMG00000014692
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: 43; II; TAF; TBN; TAFII43; TAFII-43; FLJ32821
Summary: This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 6p21.1

Sequence :: Chromosome: 6; NC_000006.11 (42018251..42048644)

See TAF8 in Epigenomics, MapViewer

Chromosome 6 - NC_000006.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47	PubMed
	tat	TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function	PubMed
	tat	A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR	PubMed
	tat	HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro	PubMed
	tat	HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
Taube nuss	P21675	TAF1	HPRD	PubMed
Taube nuss	Q12962	TAF10	HPRD	PubMed
Taube nuss	Q15544	TAF11	HPRD	PubMed
Taube nuss	Q16514	TAF12	HPRD	PubMed
Taube nuss	Q6P1X5	TAF2	HPRD	PubMed
Taube nuss	O00268	TAF4	HPRD	PubMed
Taube nuss	Q15542	TAF5	HPRD	PubMed
Taube nuss	P49848	TAF6	HPRD	PubMed
Taube nuss	Q15545	TAF7	HPRD	PubMed
Taube nuss	Q16594	TAF9	HPRD	PubMed
BioGRID:126205	BioGRID:115242	SUPT7L	BioGRID	PubMed	Affinity Capture-Western; Co-localization; FRET; Reconstituted Complex
BioGRID:126205	BioGRID:112735	TAF1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:126205	BioGRID:112744	TAF10	BioGRID	PubMed	Affinity Capture-Western; Co-purification; Reconstituted Complex
BioGRID:126205	BioGRID:112745	TAF11	BioGRID	PubMed	Affinity Capture-Western
BioGRID:126205	BioGRID:112747	TAF13	BioGRID	PubMed	Reconstituted Complex
BioGRID:126205	BioGRID:112736	TAF2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:126205	BioGRID:112737	TAF4	BioGRID	PubMed	Affinity Capture-Western; Far Western
BioGRID:126205	BioGRID:112740	TAF5	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:126205	BioGRID:112741	TAF6	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:126205	BioGRID:112742	TAF7	BioGRID	PubMed	Affinity Capture-Western
BioGRID:126205	BioGRID:126205	TAF8	BioGRID	PubMed	Affinity Capture-Western
BioGRID:126205	BioGRID:112743	TAF9	BioGRID	PubMed	Affinity Capture-Western
BioGRID:126205	BioGRID:112771	TBP	BioGRID	PubMed	Affinity Capture-Western; Co-purification; Reconstituted Complex

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
cell differentiation	IEA Inferred from Electronic Annotation more info
inner cell mass cell proliferation	IEA Inferred from Electronic Annotation more info
maintenance of protein location in nucleus	IDA Inferred from Direct Assay more info	PubMed
multicellular organismal development	IEA Inferred from Electronic Annotation more info
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
regulation of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
transcription factor TFIID complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: transcription initiation factor TFIID subunit 8

Names: transcription initiation factor TFIID subunit 8; hTAFII43; TAF(II)43; protein taube nuss; taube nuss homolog; TBP-associated factor 8; TBP-associated factor 43 kDa; TBP-associated factor TAFII43; TBP-associated factor, RNA polymerase II, 43 kD; transcription initiation factor TFIID 43 kDa subunit; TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 45/50kDa

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138572.2 → NP_612639.2 transcription initiation factor TFIID subunit 8

Status: REVIEWED

Source sequence(s)

AF465841, AL512274, BI828714

Consensus CDS

CCDS43462.1

UniProtKB/Swiss-Prot

Q7Z7C8

Related

ENSP00000362068, OTTHUMP00000216830, ENST00000372977, OTTHUMT00000357901

Conserved Domains (2) summary

cd08049
Location:144 – 197
Blast Score: 225

TAF8; TATA Binding Protein (TBP) Associated Factor 8

cl00074
Location:29 – 106
Blast Score: 264

H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000006.11 Reference GRCh37.p5 Primary Assembly

Range

42018251..42048644

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000138.1 Alternate HuRef

Range

41736207..41766572

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL512274.9	CAI16781.1
		CAI16782.1
genomic	AL513008.14	CAI15202.1
		CAI15203.1
genomic	CH471081.1	EAX04078.1
		EAX04079.1
		EAX04080.1
mRNA	AF086309.1	None
mRNA	AF465841.1	AAP47094.1
mRNA	AK057383.1	BAB71460.1
mRNA	AK303097.1	BAG64207.1
mRNA	AL833401.1	None
mRNA	BC018796.1	None
mRNA	BC033728.1	None
mRNA	BC119678.1	AAI19679.1
mRNA	BC119679.1	AAI19680.1
mRNA	BI828714.1	None