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TYW5 tRNA-yW synthesizing protein 5 [ Homo sapiens (human) ]

Gene ID: 129450, updated on 26-May-2016
Official Symbol
TYW5provided by HGNC
Official Full Name
tRNA-yW synthesizing protein 5provided by HGNC
Primary source
HGNC:HGNC:26754
See related
Ensembl:ENSG00000162971 HPRD:08232; Vega:OTTHUMG00000132770
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hTYW5; C2orf60
Orthologs
Location:
2q33.1
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (199928911..199955736, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (200793634..200820459, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927687 Neighboring gene chromosome 2 open reading frame 69 Neighboring gene uncharacterized LOC105373834 Neighboring gene chromosome 2 open reading frame 47 Neighboring gene uncharacterized LOC105373833 Neighboring gene spermatogenesis associated serine rich 2 like Neighboring gene uncharacterized LOC101927741

NHGRI GWAS Catalog

Description
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
NHGRI GWA Catalog
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Synthesis of wybutosine at G37 of tRNA(Phe), organism-specific biosystem (from REACTOME)
    Synthesis of wybutosine at G37 of tRNA(Phe), organism-specific biosystemDerivatives of wyosine are tricyclic bases found at nucleotide 37 of tRNA(Phe) in eukaryotes. The pathway of wybutosine synthesis begins with a templated guanosine residue and proceeds through 6 step...
  • tRNA modification in the nucleus and cytosol, organism-specific biosystem (from REACTOME)
    tRNA modification in the nucleus and cytosol, organism-specific biosystemAt least 92 distinct tRNA nucleotide base modifications have been found. The modifications are made post-transcriptionally by a large group of disparate enzymes located in the nucleus, cytosol, and m...
  • tRNA processing, organism-specific biosystem (from REACTOME)
    tRNA processing, organism-specific biosystemGenes encoding transfer RNAs (tRNAs) are transcribed by RNA polymerase III in the nucleus and by mitochondrial RNA polymerase in the mitochondrion.In the nucleus transcription reactions produce precu...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ37953, MGC70509
Preferred Names
tRNA wybutosine-synthesizing protein 5
Names
jmjC domain-containing protein C2orf60
tRNA yW-synthesizing enzyme 5
tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase
NP_001034782.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039693.2NP_001034782.1  tRNA wybutosine-synthesizing protein 5

    See identical proteins and their annotated locations for NP_001034782.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and is the protein-coding transcript.
    Source sequence(s)
    AC097717, BC132835, BM673915, BX647677
    Consensus CDS
    CCDS42795.1
    UniProtKB/Swiss-Prot
    A2RUC4
    Related
    ENSP00000346627, OTTHUMP00000205938, ENST00000354611, OTTHUMT00000256144
    Conserved Domains (1) summary
    pfam13621
    Location:17255
    Cupin_8; Cupin-like domain

RNA

  1. NR_004862.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of the second exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC097717, BC025758, BM673915, BX647677
    Related
    ENST00000483328, OTTHUMT00000335789
  2. NR_109905.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three alternate internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC097717, AK095272, BM673915, BX647677, CB131724, HY182974
  3. NR_109906.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of the second exon and lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC097717, AK293064, BM673915, BX647677, CB131724
  4. NR_109907.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC097717, AK095272, BM673915, BX647677, CB131724, HY182974

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    199928911..199955736 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510579.1XP_011508881.1  

    Conserved Domains (1) summary
    cl22893
    Location:17165
    JmjC; JmjC domain, hydroxylase

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    200799759..200826590 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152382.1: Suppressed sequence

    Description
    NM_152382.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.