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Crk v-crk avian sarcoma virus CT10 oncogene homolog [ Mus musculus (house mouse) ]

Gene ID: 12928, updated on 28-May-2016
Official Symbol
Crkprovided by MGI
Official Full Name
v-crk avian sarcoma virus CT10 oncogene homologprovided by MGI
Primary source
MGI:MGI:88508
See related
Ensembl:ENSMUSG00000017776
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p38; Crk3; Crko; Crk-I; c-Crk; Crk-II; CrkIII; Crk-III
Summary
This gene is part of a family of adapter proteins that mediate formation of signal transduction complexes in response to extracellular stimuli, such as growth and differentiation factors. Protein-protein interactions occur through the SH2 domain, which binds phosphorylated tyrosine residues, and the SH3 domain, which binds proline-rich peptide motifs. These interactions promote recruitment and activation of effector proteins to regulate cell migration, adhesion, and proliferation. In mouse this protein is essential for embryonic development. Alternatively spliced transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Mar 2013]
Orthologs
Location:
11 45.92 cM; 11 A-D
Exon count:
4
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (75679248..75708428)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (75492812..75519594)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate 5-phosphatase K Neighboring gene myosin IC Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide Neighboring gene double C2, beta Neighboring gene predicted gene 12339

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
SH3/SH2 adaptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging ISO
Inferred from Sequence Orthology
more info
 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylated amino acid binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ephrin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
regulation of actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
adapter molecule crk
Names
CT-10 related kinase 3
avian sarcoma virus CT10 (v-crk) oncogene homolog
proto-oncogene c-crk
v-crk sarcoma virus CT10 oncogene homolog
v-crk sarcoma virus CT10 oncogene-like protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277219.1NP_001264148.1  adapter molecule crk isoform 1

    See identical proteins and their annotated locations for NP_001264148.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform 1 (also known as CrkI). Isoform 1 (CrkI) contains the SH2 domain and the N-terminal SH3 domain, both of which are proposed to be crucial for development.
    Source sequence(s)
    AK139089, AL591440
    Consensus CDS
    CCDS70241.1
    UniProtKB/TrEMBL
    Q8JZR2
    Related
    ENSMUSP00000104063, OTTMUSP00000030601, ENSMUST00000108425, OTTMUST00000014008
    Conserved Domains (2) summary
    cd09926
    Location:5122
    SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
    cd11758
    Location:135189
    SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
  2. NM_001277221.1NP_001264150.1  adapter molecule crk isoform 3

    See identical proteins and their annotated locations for NP_001264150.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate, in-frame exon in the coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1 (CrkI). Isoform 3 does not have a complete SH2 domain and lacks an SH3 domain, both of which are found in isoform 1.
    Source sequence(s)
    AL591440
    Consensus CDS
    CCDS70242.1
    UniProtKB/TrEMBL
    Q3TQV3
    Related
    ENSMUSP00000104064, OTTMUSP00000030600, ENSMUST00000108426, OTTMUST00000062156
    Conserved Domains (1) summary
    cl15255
    Location:563
    SH2; Src homology 2 (SH2) domain
  3. NM_133656.5NP_598417.2  adapter molecule crk isoform 2

    See identical proteins and their annotated locations for NP_598417.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate segment, compared to variant 1, resulting in a longer protein (isoform 2, also known as CrkII) that has a distinct C-terminus and an additional SH3 domain, compared to isoform 1 (CrkI). Isoform 2 (CrkII) is proposed to have a negative regulatory role.
    Source sequence(s)
    AK028488, AL591440
    Consensus CDS
    CCDS25055.1
    UniProtKB/Swiss-Prot
    Q64010
    UniProtKB/TrEMBL
    Q5ND51
    Related
    ENSMUSP00000017920, OTTMUSP00000006506, ENSMUST00000017920, OTTMUST00000014007
    Conserved Domains (3) summary
    cd09926
    Location:5122
    SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
    cd11758
    Location:135189
    SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
    cd11759
    Location:237293
    SH3_CRK_C; C-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    75679248..75708428
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532125.2XP_006532188.1  

    See identical proteins and their annotated locations for XP_006532188.1

    UniProtKB/TrEMBL
    Q5ND50
    Related
    ENSMUSP00000090803, OTTMUSP00000006507, ENSMUST00000093115, OTTMUST00000014009
    Conserved Domains (2) summary
    cd09926
    Location:5122
    SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
    cd11758
    Location:135189
    SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
  2. XM_006532124.2XP_006532187.1  

    See identical proteins and their annotated locations for XP_006532187.1

    Related
    ENSMUSP00000116527, OTTMUSP00000038488, ENSMUST00000147718, OTTMUST00000062157
    Conserved Domains (3) summary
    cd09926
    Location:5122
    SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
    cd11758
    Location:135189
    SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
    cl17036
    Location:237259
    SH3; Src Homology 3 domain superfamily

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    83188359..83217539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)