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Bcar1 breast cancer anti-estrogen resistance 1 [ Mus musculus (house mouse) ]

Gene ID: 12927, updated on 28-May-2016
Official Symbol
Bcar1provided by MGI
Official Full Name
breast cancer anti-estrogen resistance 1provided by MGI
Primary source
MGI:MGI:108091
See related
Ensembl:ENSMUSG00000031955
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cas; Crkas; AI385681
Orthologs
Location:
8; 8 D3
Exon count:
9
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 8 NC_000074.6 (111710474..111743849, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (114234374..114267709, complement)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene zinc finger protein 1 Neighboring gene microRNA 7076 Neighboring gene chymotrypsinogen B1 Neighboring gene predicted gene, 39252 Neighboring gene craniofacial development protein 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
actin filament organization ISO
Inferred from Sequence Orthology
more info
 
antigen receptor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
cell migration IDA
Inferred from Direct Assay
more info
PubMed 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cellular response to hepatocyte growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
hepatocyte growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
neurotrophin TRK receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
platelet-derived growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
ruffle ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
breast cancer anti-estrogen resistance protein 1
Names
CRK-associated substrate
p130 Cas
p130cas
v-crk-associated tyrosine kinase substrate

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198839.1NP_001185768.1  breast cancer anti-estrogen resistance protein 1 isoform A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes isoform A. Isoforms A and B are the same length but differ by 4 N-terminal amino acids.
    Source sequence(s)
    AK167352, BC057578
    UniProtKB/Swiss-Prot
    Q61140
    UniProtKB/TrEMBL
    Q3TJP4
    Conserved Domains (3) summary
    cd11552
    Location:458614
    Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd11569
    Location:739871
    FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd12001
    Location:471
    SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
  2. NM_009954.3NP_034084.2  breast cancer anti-estrogen resistance protein 1 isoform B

    See identical proteins and their annotated locations for NP_034084.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, and encodes isoform B. Isoforms A and B are the same length but differ by 4 N-terminal amino acids.
    Source sequence(s)
    BC057578, BY733553
    Consensus CDS
    CCDS52675.1
    UniProtKB/Swiss-Prot
    Q61140
    Related
    ENSMUSP00000129584, ENSMUST00000166232
    Conserved Domains (3) summary
    cd11552
    Location:458614
    Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd11569
    Location:739871
    FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd12001
    Location:571
    SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p3 C57BL/6J

    Range
    111710474..111743849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248299.1XP_011246601.1  

    Conserved Domains (2) summary
    cd11552
    Location:183339
    Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd11569
    Location:464596
    FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module

Alternate Mm_Celera

Genomic

  1. AC_000030.1 Alternate Mm_Celera

    Range
    115938849..115972171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)