Crat carnitine acetyltransferase [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Cratprovided by MGI
Official Full Name: carnitine acetyltransferaseprovided by MGI
Primary source: MGI:109501
Locus tag: RP23-395P6.8
See related: Ensembl:ENSMUSG00000026853; Vega:OTTMUSG00000016795
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CARAT; AW107812

Genomic context

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Location :: 2 B; 2 21.69 cM

Sequence :: Chromosome: 2; NC_000068.7 (30400476..30415748, complement)

See Crat in Epigenomics, MapViewer

Chromosome 2 - NC_000068.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

The predicted full length cDNA sequence of the porcine CRAT gene was characterised and a new 5' variant for dog, rat and mouse was proposed.
Title: The carnitine acetyltransferase gene (CRAT): a characterization of porcine transcripts with insights into the 5'-end variants of mammalian transcripts and their possible sub-cellular localization.
structural model for L-CPT I (liver CPT I), based on the similarity of this enzyme to the recently crystallized mouse carnitine acetyltransferase
Title: Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal.
the M564G or M564A mutation is sufficient to increase the activity of the enzyme toward medium-chain substrates
Title: Structural and biochemical studies of the substrate selectivity of carnitine acetyltransferase.

Submit: New GeneRIF Correction

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation

Pathways from BioSystems

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Beta-oxidation of pristanoyl-CoA, organism-specific biosystem (from REACTOME)
Beta-oxidation of pristanoyl-CoA, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Beta-oxidation of very long chain fatty acids, organism-specific biosystem (from REACTOME)
Beta-oxidation of very long chain fatty acids, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Fatty Acid Beta Oxidation, organism-specific biosystem (from WikiPathways)
Fatty Acid Beta Oxidation, organism-specific biosystemComplete fatty acid beta-oxidation pathway for saturated and unsaturated fatty acids, developed and curated internally by BiGCaT Bioinformatics. This pathway was previously split into three parts p...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
Metabolism of lipids and lipoproteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Peroxisomal lipid metabolism, organism-specific biosystem (from REACTOME)
Peroxisomal lipid metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Peroxisome, organism-specific biosystem (from KEGG)
Peroxisome, organism-specific biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
Peroxisome, conserved biosystem (from KEGG)
Peroxisome, conserved biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...

General gene information

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Markers

AW107812 (e-PCR)
- UniSTS:178598

Crat (e-PCR), detects polymorphism
- UniSTS:506820

X85983 (e-PCR)
- UniSTS:163277

Homology

Homologs of the Crat gene: The Crat gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, C.elegans, S.cerevisiae, K.lactis, E.gossypii, M.oryzae, and N.crassa.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
carnitine O-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
receptor binding	ISO Inferred from Sequence Orthology more info
transferase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring acyl groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
carnitine metabolic process, CoA-linked	ISO Inferred from Sequence Orthology more info
fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
lipid metabolic process	IEA Inferred from Electronic Annotation more info
transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
mitochondrion	IDA Inferred from Direct Assay more info	PubMed
mitochondrion	ISO Inferred from Sequence Orthology more info
peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carnitine O-acetyltransferase

Names: carnitine O-acetyltransferase; CAT; carnitine acetylase

NP_031786.2

EC 2.3.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007760.3 → NP_031786.2 carnitine O-acetyltransferase

Status: VALIDATED

Source sequence(s)

AK041431, AK132179, AL954299

Consensus CDS

CCDS15882.1

UniProtKB/Swiss-Prot

P47934

Related

ENSMUSP00000028207, OTTMUSP00000018228, ENSMUST00000028207, OTTMUST00000040751

Conserved Domains (1) summary

pfam00755
Location:34 – 616
Blast Score: 2218

Carn_acyltransf; Choline/Carnitine o-acyltransferase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000068.7 Reference GRCm38.p1 C57BL/6J

Range

30400476..30415748, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000024.1 Alternate Mm_Celera

Range

30105381..30120546, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01014974.1 (19784..23641)	None
genomic	AAHY01014975.1	None
genomic	AL954299.13 (2000..9948)	None
genomic	AL954388.5 (124500..131824)	None
genomic	CH466542.1	EDL08471.1	mixed
mRNA	AK028666.1	None	C57BL/6J
mRNA	AK041431.1	None	C57BL/6J
mRNA	AK132179.1	BAE21016.1	C57BL/6J
mRNA	AK170740.1	BAE41993.1	NOD
mRNA	AK187827.1	None
mRNA	AK190909.1	None
mRNA	AK197476.1	None
mRNA	AK204553.1	None
mRNA	AK207535.1	None
mRNA	AK217535.1	None
mRNA	AK218779.1	None
mRNA	AK219597.1	None
mRNA	BC006668.1	AAH06668.1	FVB/N
mRNA	X85983.1	CAA59971.1