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Cpeb1 cytoplasmic polyadenylation element binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 12877, updated on 8-May-2016
Official Symbol
Cpeb1provided by MGI
Official Full Name
cytoplasmic polyadenylation element binding protein 1provided by MGI
Primary source
MGI:MGI:108442
See related
Ensembl:ENSMUSG00000025586 Vega:OTTMUSG00000024594
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cpeb; mCPEB; AU024112
Orthologs
Location:
7; 7 D3
Exon count:
17
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (81347026..81455457, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (88492329..88599562, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 8A Neighboring gene translocase of inner mitochondrial membrane 17a pseudogene Neighboring gene ribosomal protein S17 Neighboring gene small nuclear ribonucleoprotein 48 (U11/U12) pseudogene Neighboring gene ribosomal protein L7A, pseudogene 9 Neighboring gene adaptor-related protein complex 3, beta 2 subunit Neighboring gene cDNA sequence BC048679

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Dorso-ventral axis formation, organism-specific biosystem (from KEGG)
    Dorso-ventral axis formation, organism-specific biosystem
    Dorso-ventral axis formation
  • Dorso-ventral axis formation, conserved biosystem (from KEGG)
    Dorso-ventral axis formation, conserved biosystem
    Dorso-ventral axis formation
  • Oocyte meiosis, organism-specific biosystem (from KEGG)
    Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
  • Oocyte meiosis, conserved biosystem (from KEGG)
    Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
  • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
    Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
  • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
    Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
  • mRNA processing, organism-specific biosystem (from WikiPathways)
    mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC159179

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
 
translation factor activity, RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
translation repressor activity, nucleic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular response to amino acid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
mRNA transport ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cytoplasmic translation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
regulation of neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
synaptonemal complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
growth cone ISO
Inferred from Sequence Orthology
more info
 
intracellular ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
meiotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
messenger ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
cytoplasmic polyadenylation element-binding protein 1
Names
CPE-BP1
CPE-binding protein 1
mCPEB-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252525.1NP_001239454.1  cytoplasmic polyadenylation element-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001239454.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AK077799, BC125476, BY720025, CO803180
    Consensus CDS
    CCDS57557.1
    UniProtKB/Swiss-Prot
    P70166
    UniProtKB/TrEMBL
    Q059Z2
    Related
    ENSMUSP00000137079, OTTMUSP00000075578, ENSMUST00000178892, OTTMUST00000145061
    Conserved Domains (3) summary
    smart00360
    Location:312379
    RRM; RNA recognition motif
    cd12723
    Location:309416
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:427512
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  2. NM_001252526.1NP_001239455.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a different splice in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK077799, BC125476, BC144948, BY720025, CO803180
    UniProtKB/Swiss-Prot
    P70166
    UniProtKB/TrEMBL
    Q059Z2
    Related
    ENSMUSP00000120139, OTTMUSP00000029473, ENSMUST00000130310, OTTMUST00000060425
    Conserved Domains (3) summary
    smart00360
    Location:311373
    RRM; RNA recognition motif
    cd12723
    Location:308410
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:421506
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  3. NM_007755.5NP_031781.1  cytoplasmic polyadenylation element-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_031781.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK077799, BC144948, BY720025, CO803180, Y08260
    Consensus CDS
    CCDS40007.1
    UniProtKB/Swiss-Prot
    P70166
    Related
    ENSMUSP00000095936, OTTMUSP00000029472, ENSMUST00000098331, OTTMUST00000060424
    Conserved Domains (3) summary
    smart00360
    Location:311378
    RRM; RNA recognition motif
    cd12723
    Location:308415
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:426511
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    81347026..81455457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250791.1XP_011249093.1  

    See identical proteins and their annotated locations for XP_011249093.1

    Conserved Domains (3) summary
    smart00360
    Location:236303
    RRM; RNA recognition motif
    cd12723
    Location:233340
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:351436
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  2. XM_011250788.1XP_011249090.1  

    Conserved Domains (3) summary
    smart00360
    Location:350400
    RRM; RNA recognition motif
    cd12723
    Location:347437
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:448533
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  3. XM_011250784.1XP_011249086.1  

    Conserved Domains (3) summary
    smart00360
    Location:350417
    RRM; RNA recognition motif
    cd12723
    Location:347454
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:465550
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  4. XM_011250785.1XP_011249087.1  

    Conserved Domains (3) summary
    smart00360
    Location:349416
    RRM; RNA recognition motif
    cd12723
    Location:346453
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:464549
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  5. XM_011250786.1XP_011249088.1  

    Conserved Domains (3) summary
    smart00360
    Location:350412
    RRM; RNA recognition motif
    cd12723
    Location:347449
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:460545
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  6. XM_011250787.1XP_011249089.1  

    Conserved Domains (3) summary
    smart00360
    Location:349411
    RRM; RNA recognition motif
    cd12723
    Location:346448
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:459544
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  7. XM_011250789.1XP_011249091.1  

    Conserved Domains (3) summary
    smart00360
    Location:323390
    RRM; RNA recognition motif
    cd12723
    Location:320427
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:438523
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  8. XM_011250790.1XP_011249092.1  

    See identical proteins and their annotated locations for XP_011249092.1

    Conserved Domains (3) summary
    smart00360
    Location:236303
    RRM; RNA recognition motif
    cd12723
    Location:233340
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:351436
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  9. XM_011250792.1XP_011249094.1  

    Conserved Domains (3) summary
    smart00360
    Location:182249
    RRM; RNA recognition motif
    cd12723
    Location:179286
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:297382
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    78752201..78860136 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)