Copa coatomer protein complex subunit alpha [Mus musculus] - Gene

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Summary

Official Symbol: Copaprovided by MGI
Official Full Name: coatomer protein complex subunit alphaprovided by MGI
Primary source: MGI:1334462
See related: Ensembl:ENSMUSG00000026553; Vega:OTTMUSG00000033968
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: xenin; AU040324

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Genomic context

Location :: 1 H3; 1 93.5 cM

Sequence :: Chromosome: 1; NC_000067.6 (172082529..172122332)

See Copa in Epigenomics, MapViewer

Chromosome 1 - NC_000067.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SMN directly binds to COPI and moves with survival motor neuron within axons.
Title: The COPI vesicle complex binds and moves with survival motor neuron within axons.
In a a large-scale functional screening of mesothelioma cells, the COPA protein was highly expressed in some mesothelioma cell lines but not in a pleural mesothelial cell line.
Title: Knockdown of COPA, identified by loss-of-function screen, induces apoptosis and suppresses tumor growth in mesothelioma mouse model.

Submit: New GeneRIF Correction

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:198835	BioGRID:106867	ARCN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:198835	BioGRID:122115	ATL2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:198835	BioGRID:115437	BCAP31	BioGRID	PubMed	Affinity Capture-MS
BioGRID:198835	BioGRID:107709	COPA	BioGRID	PubMed	Affinity Capture-MS
BioGRID:198835	BioGRID:107710	COPB1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:198835	BioGRID:114693	COPB2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:198835	BioGRID:116447	COPE	BioGRID	PubMed	Affinity Capture-MS
BioGRID:198835	BioGRID:116496	COPG1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:198835	BioGRID:116495	COPZ1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:198835	BioGRID:119441	ERGIC2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:198835	BioGRID:116722	SIPA1L3	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
hormone activity	IEA Inferred from Electronic Annotation more info
structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
intracellular protein transport	IEA Inferred from Electronic Annotation more info
pancreatic juice secretion	ISO Inferred from Sequence Orthology more info
protein transport	IEA Inferred from Electronic Annotation more info
transport	IEA Inferred from Electronic Annotation more info
vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
COPI vesicle coat	ISO Inferred from Sequence Orthology more info
Golgi apparatus	IEA Inferred from Electronic Annotation more info
cytoplasm	ISO Inferred from Sequence Orthology more info
cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	ISO Inferred from Sequence Orthology more info
membrane	IEA Inferred from Electronic Annotation more info
membrane coat	IEA Inferred from Electronic Annotation more info
microsome	ISO Inferred from Sequence Orthology more info
soluble fraction	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: coatomer subunit alpha

Names: coatomer subunit alpha; alpha-COP; alpha-coat protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009938.4 → NP_034068.3 coatomer subunit alpha

Status: VALIDATED

Source sequence(s)

AC158930, AK043479, AW537456, CF734857

Consensus CDS

CCDS35780.1

UniProtKB/TrEMBL

Q8BTF0

UniProtKB/Swiss-Prot

Q8CIE6

Related

ENSMUSP00000118179, OTTMUSP00000046332, ENSMUST00000135192, OTTMUST00000085713

Conserved Domains (3) summary

cd00200
Location:9 – 318
Blast Score: 581

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam06957
Location:815 – 1224
Blast Score: 1854

COPI_C; Coatomer (COPI) alpha subunit C-terminus

pfam04053
Location:339 – 767
Blast Score: 1365

Coatomer_WDAD; Coatomer WD associated region

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000067.6 Reference GRCm38 C57BL/6J

Range

172082529..172122332

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000023.1 Alternate Mm_Celera

Range

174936820..174976641

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC158930.3 (186020..194254)	None
genomic	AJ010391.1	CAB53163.1	CBA/Ca
genomic	CH466520.2	EDL39042.1	mixed
		EDL39043.1	mixed
mRNA	AF248032.1	AAG00913.1
mRNA	AK032071.1	BAC27682.1	C57BL/6J
mRNA	AK043479.1	BAC31555.1	C57BL/6J
mRNA	AK052724.1	None	C57BL/6J
mRNA	AK162632.1	None	C57BL/6J
mRNA	AK164910.1	None	C57BL/6J
mRNA	AK171625.1	BAE42571.1	NOD
mRNA	AK181160.1	None
mRNA	AK181897.1	None
mRNA	AK183333.1	None
mRNA	AK186200.1	None
mRNA	AK186354.1	None
mRNA	AK189379.1	None
mRNA	AK191029.1	None
mRNA	AK192504.1	None
mRNA	AK193412.1	None
mRNA	AK194620.1	None
mRNA	AK199106.1	None
mRNA	AK199738.1	None
mRNA	AK200292.1	None
mRNA	AK201689.1	None
mRNA	AK202860.1	None
mRNA	AK206256.1	None
mRNA	AK206551.1	None
mRNA	AK213078.1	None
mRNA	AW537456.1	None	C57BL/6J
mRNA	BC005609.1	AAH05609.1	FVB/N
mRNA	BC024070.1	AAH24070.1	FVB/N
mRNA	BC025896.1	AAH25896.1	CZECHII
mRNA	BC047429.1	AAH47429.1	FVB/N
mRNA	BC082785.1	AAH82785.1	CZECHII
mRNA	CF734857.1	None	C57BL/6

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q3TAU7	GenPept	UniProtKB/TrEMBL:Q3TAU7
Q63ZW9	GenPept	UniProtKB/TrEMBL:Q63ZW9
Q8BTF0	GenPept	UniProtKB/TrEMBL:Q8BTF0
Q8BTF3	GenPept	UniProtKB/TrEMBL:Q8BTF3
Q8CIE6.2	GenPept	UniProtKB/Swiss-Prot:Q8CIE6
Q8R393	GenPept	UniProtKB/TrEMBL:Q8R393
Q99JW9	GenPept	UniProtKB/TrEMBL:Q99JW9
Q9ET41	GenPept	UniProtKB/TrEMBL:Q9ET41
Q9R0Y3	GenPept	UniProtKB/TrEMBL:Q9R0Y3