APOA1BP apolipoprotein A-I binding protein [Homo sapiens] - Gene

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Summary

Official Symbol: APOA1BPprovided by HGNC
Official Full Name: apolipoprotein A-I binding proteinprovided by HGNC
Primary source: HGNC:18453
Locus tag: RP11-284F21.3
See related: Ensembl:ENSG00000163382; HPRD:16397; MIM:608862; Vega:OTTHUMG00000033206
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AIBP; YJEFN1
Summary: The product of this gene interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I. The human genome contains related pseudogenes. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 1q21

Sequence :: Chromosome: 1; NC_000001.10 (156561558..156564091)

See APOA1BP in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Taken together, the current study demonstrates that APN might protect against atherosclerosis by increasing HDL assembly through enhancing ABCA1 pathway and apoA-1 synthesis in the liver.
Title: Adiponectin accelerates reverse cholesterol transport by increasing high density lipoprotein assembly in the liver.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Apolipoprotein A-I binding protein	P02647	APOA1	HPRD	PubMed
Apolipoprotein A-I binding protein	P02652	APOA2	HPRD	PubMed
BioGRID:126103	BioGRID:106832	APOA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:126103	BioGRID:109268	H2AFX	BioGRID	PubMed	Affinity Capture-MS
BioGRID:126103	BioGRID:111583	MAPK6	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
extracellular region	IDA Inferred from Direct Assay more info	PubMed
mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: apolipoprotein A-I-binding protein

Names: apolipoprotein A-I-binding protein; AI-BP; yjeF_N1; apoA-I binding protein; yjeF N-terminal domain-containing protein 1

NP_658985.2

EC 3.6.5.4

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144772.2 → NP_658985.2 apolipoprotein A-I-binding protein precursor

Status: REVIEWED

Source sequence(s)

AL365181, BC100933, BG723681, BQ430064

Consensus CDS

CCDS1145.1

UniProtKB/Swiss-Prot

Q8NCW5

Related

ENSP00000357218, OTTHUMP00000031989, ENST00000368235, OTTHUMT00000081044

Conserved Domains (1) summary

cl00318
Location:52 – 287
Blast Score: 678

YjeF_N; YjeF-related protein N-terminus

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

156561558..156564091

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

127919237..127921770

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL365181.24	CAI13049.1
		CAI13050.1
		CAI13051.1
genomic	CH471121.2	EAW52941.1
		EAW52942.1
		EAW52943.1
mRNA	AJ315849.1	CAC86580.1
mRNA	AK294835.1	BAG57944.1
mRNA	AK298222.1	BAG60492.1
mRNA	BC056917.1	AAH56917.1
mRNA	BC100931.1	AAI00932.1
mRNA	BC100932.1	AAI00933.1
mRNA	BC100933.1	AAI00934.1
mRNA	BC100934.2	AAI00935.1
mRNA	BG723681.1	None
mRNA	BQ430064.1	None

Protein Accession	Links
Protein Accession	GenePept Link	UniProtKB Link
Q5T3I3	GenPept	UniProtKB/TrEMBL:Q5T3I3
Q6PGN4	GenPept	UniProtKB/TrEMBL:Q6PGN4
Q8NCW5.2	GenPept	UniProtKB/Swiss-Prot:Q8NCW5