Cntfr ciliary neurotrophic factor receptor [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Cntfrprovided by MGI
Official Full Name: ciliary neurotrophic factor receptorprovided by MGI
Primary source: MGI:99605
Locus tag: RP23-167I12.1
See related: Ensembl:ENSMUSG00000028444; Vega:OTTMUSG00000006676
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cntfralpha

Genomic context

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Location :: 4 A5; 4 21.81 cM

Sequence :: Chromosome: 4; NC_000070.6 (41657498..41697091, complement)

See Cntfr in Epigenomics, MapViewer

Chromosome 4 - NC_000070.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that CNTF receptor alpha subunit, CNTFRalpha, signaling in leptin-responsive neurons is not required for endogenous maintenance of energy balance.
Title: The anorectic effect of CNTF does not require action in leptin-responsive neurons.
CNTF receptor signaling, likely by the MNs themselves, can play an essential role in MN survival. This role is independent of any developmental contributions CNTF receptor signaling makes to MN survival or function.
Title: Conditional, genetic disruption of ciliary neurotrophic factor receptors reveals a role in adult motor neuron survival.
Co-administration of ciliary neurotrophic factor with its soluble receptor protects against neuronal death and enhances neurite outgrowth.
Title: Co-administration of ciliary neurotrophic factor with its soluble receptor protects against neuronal death and enhances neurite outgrowth.
CNTF-CNTFRalpha activates the JAK/STAT pathway leading to enhanced Cx43 expression and intercellular coupling
Title: The complex of ciliary neurotrophic factor-ciliary neurotrophic factor receptor alpha up-regulates connexin43 and intercellular coupling in astrocytes via the Janus tyrosine kinase/signal transducer and activator of transcription pathway.
It is suggested that the loss of CNTFRalpha from axons renders RGCs unresponsive to CNTF, thereby contributing to regenerative failure and death, while its appearance on glia may promote glial scarring.
Title: Immunohistochemical localization of CNTFRalpha in adult mouse retina and optic nerve following intraorbital nerve crush: evidence for the axonal loss of a trophic factor receptor after injury.
identification of neuropoietin as a new ligand with with important implications for murine nervous system development
Title: Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor.

Submit: New GeneRIF Correction

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (2) 1 citation
Targeted (knock-out) (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:198796	BioGRID:198795	Cntf		BioGRID	PubMed	Affinity Capture-Western
BioGRID:198796	BioGRID:232625	Ctf2		BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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Adipogenesis, organism-specific biosystem (from WikiPathways)
Adipogenesis, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Jak-STAT signaling pathway, conserved biosystem (from KEGG)
Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...

General gene information

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Markers

D17Mit264 (e-PCR), detects polymorphism
- UniSTS:128075

AW553376 (e-PCR)
- UniSTS:181136

UniSTS:496823 (e-PCR)
- UniSTS:496823

Cntfr (e-PCR), detects polymorphism
- UniSTS:496823

AW987258 (e-PCR)
- UniSTS:185578

AF004927 (e-PCR)
- UniSTS:159226

Homology

Homologs of the Cntfr gene: The Cntfr gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ciliary neurotrophic factor receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
ciliary neurotrophic factor receptor activity	ISO Inferred from Sequence Orthology more info
cytokine binding	ISO Inferred from Sequence Orthology more info
cytokine receptor activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
brainstem development	IMP Inferred from Mutant Phenotype more info	PubMed
ciliary neurotrophic factor-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
ciliary neurotrophic factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
sex differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
skeletal muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
suckling behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
CNTFR-CLCF1 complex	ISO Inferred from Sequence Orthology more info
anchored to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ciliary neurotrophic factor receptor subunit alpha

Names: ciliary neurotrophic factor receptor subunit alpha; CNTFR-alpha; CNTF receptor subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001136056.2 → NP_001129528.1 ciliary neurotrophic factor receptor subunit alpha isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

BC046974, CX202454

Consensus CDS

CCDS18067.1

UniProtKB/Swiss-Prot

O88507

Related

ENSMUSP00000100026, OTTMUSP00000007063, ENSMUST00000102961, OTTMUST00000015290

Conserved Domains (2) summary

cd00063
Location:204 – 300
Blast Score: 116

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

smart00408
Location:39 – 96
Blast Score: 128

IGc2; Immunoglobulin C-2 Type
NM_001146080.1 → NP_001139552.1 ciliary neurotrophic factor receptor subunit alpha isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate exon at the 3' end compared to variant 1. This results in a frame-shift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.

Source sequence(s)

AK015675, AL831723, BY715214

Consensus CDS

CCDS51142.1

UniProtKB/TrEMBL

Q9D586

Related

ENSMUSP00000081751, OTTMUSP00000007065, ENSMUST00000084701, OTTMUST00000015292

Conserved Domains (1) summary

smart00408
Location:39 – 96
Blast Score: 128

IGc2; Immunoglobulin C-2 Type
NM_016673.2 → NP_057882.2 ciliary neurotrophic factor receptor subunit alpha isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 2 encode the same protein.

Source sequence(s)

AL831723, BC046974, BY715214

Consensus CDS

CCDS18067.1

UniProtKB/Swiss-Prot

O88507

Related

ENSMUSP00000100027, OTTMUSP00000007064, ENSMUST00000102962, OTTMUST00000015291

Conserved Domains (2) summary

cd00063
Location:204 – 300
Blast Score: 116

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

smart00408
Location:39 – 96
Blast Score: 128

IGc2; Immunoglobulin C-2 Type

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000070.6 Reference GRCm38.p1 C57BL/6J

Range

41657498..41697091, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000026.1 Alternate Mm_Celera

Range

41319986..41355439, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01035261.1	None
genomic	AAHY01035262.1	None
genomic	AAHY01035263.1	None
genomic	AAHY01035264.1	None
genomic	AAHY01035265.1 (73..4082)	None
genomic	AL807796.17 (14083..53677)	None
genomic	AL831723.9 (223089..223100)	None
genomic	CH466538.2	EDL05393.1	mixed
mRNA	AB154246.1	BAI44631.1	DDY
mRNA	AF068615.1	AAC25711.1
mRNA	AK015675.1	BAB29926.1	C57BL/6J
mRNA	AK137026.1	BAE23207.1	C57BL/6J
mRNA	AK194669.1	None
mRNA	BC046974.1	AAH46974.1
mRNA	BC050928.1	AAH50928.1	C57BL/6
mRNA	BY715214.1	None	C57BL/6J
mRNA	CX202454.1	None	C57BL/6