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Cntf ciliary neurotrophic factor [ Mus musculus (house mouse) ]

Gene ID: 12803, updated on 8-May-2016
Official Symbol
Cntfprovided by MGI
Official Full Name
ciliary neurotrophic factorprovided by MGI
Primary source
MGI:MGI:88439
See related
Ensembl:ENSMUSG00000079415 Vega:OTTMUSG00000024775
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI429687
Summary
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes, and it may be involved in reducing tissue destruction during inflammatory attacks. A read-through transcript variant composed of Zfp91 and Cntf sequences has been identified, but it is thought to be non-coding. Read-through transcription of Zfp91 and Cntf has been observed in both human and mouse. [provided by RefSeq, Aug 2008]
Orthologs
Location:
19 A; 19 8.73 cM
Exon count:
2
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 19 NC_000085.6 (12763528..12765632, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (12838018..12840122, complement)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene olfactory receptor 1443 Neighboring gene kidney expressed gene 1 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene predicted readthrough transcript (NMD candidate), 44505 Neighboring gene zinc finger protein 91 Neighboring gene leupaxin

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Readthrough Zfp91Cntf

Readthrough gene: Zfp91Cntf, Included gene: Zfp91

Homology

Clone Names

  • MGC41235

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ciliary neurotrophic factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
ciliary neurotrophic factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
cytokine activity ISO
Inferred from Sequence Orthology
more info
 
growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
interleukin-6 receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
JAK-STAT cascade ISO
Inferred from Sequence Orthology
more info
 
astrocyte activation IBA
Inferred from Biological aspect of Ancestor
more info
 
astrocyte activation ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
ciliary neurotrophic factor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
ciliary neurotrophic factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
growth IEA
Inferred from Electronic Annotation
more info
 
membrane hyperpolarization ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
muscle organ morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of photoreceptor cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
nervous system development ISO
Inferred from Sequence Orthology
more info
 
neuron development IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of JAK-STAT cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of axon regeneration IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of axon regeneration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of hormone secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of Stat3 protein IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tyrosine phosphorylation of Stat3 protein ISO
Inferred from Sequence Orthology
more info
 
protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
 
regulation of resting membrane potential ISO
Inferred from Sequence Orthology
more info
 
regulation of retinal cell programmed cell death IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with CRLF-CLCF1 complex ISO
Inferred from Sequence Orthology
more info
 
axon IBA
Inferred from Biological aspect of Ancestor
more info
 
axon ISO
Inferred from Sequence Orthology
more info
 
cell projection cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
ciliary neurotrophic factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_170786.2NP_740756.1  ciliary neurotrophic factor

    See identical proteins and their annotated locations for NP_740756.1

    Status: REVIEWED

    Source sequence(s)
    BC027539, BQ033243, W08735
    Consensus CDS
    CCDS29637.1
    UniProtKB/Swiss-Prot
    P51642
    UniProtKB/TrEMBL
    Q544D1
    Related
    ENSMUSP00000108555, OTTMUSP00000029848, ENSMUST00000112933, OTTMUST00000061010
    Conserved Domains (1) summary
    pfam01110
    Location:1186
    CNTF; Ciliary neurotrophic factor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p3 C57BL/6J

    Range
    12763528..12765632 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000041.1 Alternate Mm_Celera

    Range
    13428744..13430848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_053007.2: Suppressed sequence

    Description
    NM_053007.2: This RefSeq was permanently suppressed because it actually represents the Zfp91-Cntf readthrough transcript, and not just Cntf.