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Camp cathelicidin antimicrobial peptide [ Mus musculus (house mouse) ]

Gene ID: 12796, updated on 17-May-2016
Official Symbol
Campprovided by MGI
Official Full Name
cathelicidin antimicrobial peptideprovided by MGI
Primary source
MGI:MGI:108443
See related
Ensembl:ENSMUSG00000038357
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cnlp; MCLP; CAP18; Cramp; FALL39
Summary
This gene encodes a member of the cathelicidin family of antimicrobial peptides that play an important role in the defense against microbial infection. The encoded preproprotein undergoes proteolytic processing to generate a mature polypeptide before secretion by host cells such as neutrophils, epithelial cells and macrophages. Mice lacking the encoded protein exhibit increased susceptibility to group A streptococcus and Escherichia coli infections. [provided by RefSeq, Oct 2015]
Orthologs
Location:
9 F2; 9 59.8 cM
Exon count:
4
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 9 NC_000075.6 (109847377..109849456, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (109749891..109751970, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene NME/NM23 nucleoside diphosphate kinase 6 Neighboring gene predicted gene, 39427 Neighboring gene cell division cycle 25A Neighboring gene microRNA 7089

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Salivary secretion, organism-specific biosystem (from KEGG)
    Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Salivary secretion, conserved biosystem (from KEGG)
    Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
antibacterial humoral response ISO
Inferred from Sequence Orthology
more info
 
antifungal humoral response ISO
Inferred from Sequence Orthology
more info
 
chronic inflammatory response ISO
Inferred from Sequence Orthology
more info
 
defense response IEA
Inferred from Electronic Annotation
more info
 
defense response to Gram-negative bacterium IDA
Inferred from Direct Assay
more info
PubMed 
defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to bacterium ISO
Inferred from Sequence Orthology
more info
PubMed 
innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
innate immune response ISO
Inferred from Sequence Orthology
more info
 
innate immune response in mucosa ISO
Inferred from Sequence Orthology
more info
 
killing by host of symbiont cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
killing by host of symbiont cells ISO
Inferred from Sequence Orthology
more info
 
negative regulation of growth of symbiont in host IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of growth of symbiont on or near host surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of growth of symbiont on or near host surface ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-8 secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
response to yeast ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell projection ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
intracellular ISO
Inferred from Sequence Orthology
more info
 
specific granule IDA
Inferred from Direct Assay
more info
PubMed 
specific granule ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
cathelicidin antimicrobial peptide
Names
CLP
cathelin-like protein
cathelin-related antimicrobial peptide

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009921.2NP_034051.2  cathelicidin antimicrobial peptide precursor

    See identical proteins and their annotated locations for NP_034051.2

    Status: REVIEWED

    Source sequence(s)
    BC120754, BY582734, U43409
    Consensus CDS
    CCDS52934.1
    UniProtKB/Swiss-Prot
    P51437
    UniProtKB/TrEMBL
    A0A0R4J1G2
    Related
    ENSMUSP00000107653, OTTMUSP00000022449, ENSMUST00000112022, OTTMUST00000048760
    Conserved Domains (2) summary
    pfam00666
    Location:2995
    Cathelicidins; Cathelicidin
    pfam12153
    Location:139166
    CAP18_C; LPS binding domain of CAP18 (C terminal)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p3 C57BL/6J

    Range
    109847377..109849456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000031.1 Alternate Mm_Celera

    Range
    109574006..109576084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)