Ccr7 chemokine (C-C motif) receptor 7 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Ccr7provided by MGI
Official Full Name: chemokine (C-C motif) receptor 7provided by MGI
Primary source: MGI:103011
Locus tag: RP23-80N1.2
See related: Ensembl:ENSMUSG00000037944; Vega:OTTMUSG00000006448
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EBI1; CD197; Ebi1h; Cdw197; Cmkbr7

Genomic context

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Location :: 11 D; 11

Sequence :: Chromosome: 11; NC_000077.6 (99144199..99155077, complement)

See Ccr7 in Epigenomics, MapViewer

Chromosome 11 - NC_000077.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that naive lung CD4 cells supply the draining lymph nodes through a CD62L-independent, CCR7-dependent pathway.
Title: Analysis of naïve lung CD4 T cells provides evidence of functional lung to lymph node migration.
Exposure to CCR7 in a model of contact hypersensitivity following sublethal total body irradiation results in diminished immunosurveillance in the skin, a mechanism which could render the host more susceptible to pathogens.
Title: Exposure to ionizing radiation induces the migration of cutaneous dendritic cells by a CCR7-dependent mechanism.
these data imply a causal link between CCR7 expression, IL-1beta level, and Na malabsorption owing to altered ENaC expression and diarrhea.
Title: CCR7 deficiency causes diarrhea associated with altered ion transport in colonocytes in the absence of overt colitis.
Phosphatidylinositol 3-kinase and NF-kappa B signaling pathways play a critical role in CCR7-mediated IL-23 production by murine dendritic cells.
Title: CCR7 ligands up-regulate IL-23 through PI3-kinase and NF-κ B pathway in dendritic cells.
Plasmacytoid dendritic cells (pDCs) trafficking to the splenic white pulp require CCR7 signaling.
Title: Constitutive plasmacytoid dendritic cell migration to the splenic white pulp is cooperatively regulated by CCR7- and CXCR4-mediated signaling.
CCR7 expression contributes to the immunopathogenesis of allergic conjuctivitis, thereby allowing significant inhibition of this experimental condition via topical CCR7 antibody blockade.
Title: Blocking CCR7 at the ocular surface impairs the pathogenic contribution of dendritic cells in allergic conjunctivitis.
Cell sorting highlighted the involvement of CD11c(+) cells in the CCR7-independent transport.
Title: CCR7-independent transport of skin antigens occurs in the dermis.
Statins promote the beneficial remodeling of plaques in diseased mouse arteries through the stimulation of the CCR7 / CD68 emigration pathway in macrophages
Title: Statins promote the regression of atherosclerosis via activation of the CCR7-dependent emigration pathway in macrophages.
demonstrate here that immuno-regulation through CCR7 expression in T cells plays a role in house dust mite-specific sensitization in the airway
Title: The role of CCR7 in allergic airway inflammation induced by house dust mite exposure.
analysis of manifestation of spontaneous and early autoimmune gastritis in CCR7-deficient mice
Title: Manifestation of spontaneous and early autoimmune gastritis in CCR7-deficient mice.

Submit: New GeneRIF Correction See all (96)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (1) 1 citation
Targeted (Reporter) (1)
Gene trapped (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
NP_031745.1	NP_036018.1	Ccl19		BIND	PubMed	CCR7 interacts with CCL19.

Pathways from BioSystems

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Chemokine receptors bind chemokines, organism-specific biosystem (from REACTOME)
Chemokine receptors bind chemokines, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Chemokine signaling pathway, organism-specific biosystem (from KEGG)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, organism-specific biosystem (from WikiPathways)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, conserved biosystem (from KEGG)
Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
Class A/1 (Rhodopsin-like receptors), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
G alpha (i) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR ligand binding, organism-specific biosystem (from REACTOME)
GPCR ligand binding, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCRs, Other, organism-specific biosystem (from WikiPathways)
GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
Non-odorant GPCRs, organism-specific biosystem (from WikiPathways)
Non-odorant GPCRs, organism-specific biosystemListing of non-odorant Mouse GCPRs by coupling.
Peptide GPCRs, organism-specific biosystem (from WikiPathways)
Peptide GPCRs, organism-specific biosystem
Peptide GPCRs
Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
Peptide ligand-binding receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
Transcriptional misregulation in cancer, organism-specific biosystem
Transcriptional misregulation in cancer
Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
Transcriptional misregulation in cancer, conserved biosystem
Transcriptional misregulation in cancer

General gene information

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Markers

Ccr7 (e-PCR), detects polymorphism
- UniSTS:495963

Ccr7 (e-PCR), detects polymorphism
- UniSTS:463200

PMC321570P11 (e-PCR)
- UniSTS:273114

Homology

Homologs of the Ccr7 gene: The Ccr7 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
C-C chemokine receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
C-C motif chemokine 19 receptor activity	ISO Inferred from Sequence Orthology more info
C-C motif chemokine 21 receptor activity	ISO Inferred from Sequence Orthology more info
G-protein coupled receptor activity	TAS Traceable Author Statement more info	PubMed
chemokine (C-C motif) ligand 19 binding	ISO Inferred from Sequence Orthology more info
chemokine (C-C motif) ligand 21 binding	ISO Inferred from Sequence Orthology more info
chemokine receptor activity	IEA Inferred from Electronic Annotation more info
signal transducer activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
G-protein coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
actin cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
activation of JUN kinase activity	IC Inferred by Curator more info	PubMed
chemokine (C-C motif) ligand 19 signaling pathway	ISO Inferred from Sequence Orthology more info
chemokine (C-C motif) ligand 21 signaling pathway	ISO Inferred from Sequence Orthology more info
chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
chemokine-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
elevation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
establishment of T cell polarity	TAS Traceable Author Statement more info	PubMed
immune response	IMP Inferred from Mutant Phenotype more info	PubMed
inflammatory response	NAS Non-traceable Author Statement more info
inflammatory response	TAS Traceable Author Statement more info	PubMed
interleukin-12 secretion	IMP Inferred from Mutant Phenotype more info
lymph node development	TAS Traceable Author Statement more info	PubMed
lymphocyte chemotaxis across high endothelial venule	TAS Traceable Author Statement more info
lymphocyte migration into lymph node	TAS Traceable Author Statement more info	PubMed
mature dendritic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of leukocyte apoptotic process	TAS Traceable Author Statement more info	PubMed
negative thymic T cell selection	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of Cdc42 GTPase activity	IC Inferred by Curator more info	PubMed
positive regulation of Ras GTPase activity	IC Inferred by Curator more info	PubMed
positive regulation of T cell chemotaxis	TAS Traceable Author Statement more info
positive regulation of T cell costimulation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of T cell proliferation	IC Inferred by Curator more info	PubMed
positive regulation of T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of T-helper 1 cell differentiation	IC Inferred by Curator more info	PubMed
positive regulation of cell motility	TAS Traceable Author Statement more info	PubMed
positive regulation of dendritic cell antigen processing and presentation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of dendritic cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of filopodium assembly	TAS Traceable Author Statement more info	PubMed
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of humoral immune response	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of hypersensitivity	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of immunological synapse formation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of interleukin-1 beta secretion	IC Inferred by Curator more info	PubMed
positive regulation of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of macrophage chemotaxis	NAS Non-traceable Author Statement more info
positive regulation of neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info
positive regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
positive regulation of phagocytosis	NAS Non-traceable Author Statement more info	PubMed
positive regulation of receptor-mediated endocytosis	IC Inferred by Curator more info	PubMed
positive regulation of thymocyte migration	TAS Traceable Author Statement more info	PubMed
positive regulation of tumor necrosis factor production	IC Inferred by Curator more info	PubMed
regulation of dendritic cell dendrite assembly	IC Inferred by Curator more info	PubMed
regulation of interferon-gamma production	IMP Inferred from Mutant Phenotype more info
regulation of interleukin-1 beta secretion	IMP Inferred from Mutant Phenotype more info
regulation of tolerance induction to self antigen	TAS Traceable Author Statement more info	PubMed
response to lipopolysaccharide	IDA Inferred from Direct Assay more info
response to nitric oxide	TAS Traceable Author Statement more info	PubMed
response to prostaglandin E stimulus	TAS Traceable Author Statement more info	PubMed
signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
integral to membrane	IEA Inferred from Electronic Annotation more info
intracellular	IDA Inferred from Direct Assay more info
intracellular	ISO Inferred from Sequence Orthology more info
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info
plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-C chemokine receptor type 7

Names: C-C chemokine receptor type 7; CCR-7; CC-CKR-7; C-C CKR-7; MIP-3 beta receptor; chemokine (C-C) receptor 7; EBV-induced G-protein coupled receptor 1; epstein-Barr virus-induced G-protein coupled receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007719.2 → NP_031745.2 C-C chemokine receptor type 7 precursor

Status: VALIDATED

Source sequence(s)

AK037965, BF020112

Consensus CDS

CCDS25373.1

UniProtKB/Swiss-Prot

P47774

Related

ENSMUSP00000099423, OTTMUSP00000006846, ENSMUST00000103134, OTTMUST00000014735

Conserved Domains (1) summary

pfam00001
Location:81 – 326
Blast Score: 393

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000077.6 Reference GRCm38.p1 C57BL/6J

Range

99144199..99155077, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000033.1 Alternate Mm_Celera

Range

108811008..108821915, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01095725.1 (10566..15655)	None
genomic	AAHY01095726.1	None
genomic	AL591366.15 (92331..103209)	None
genomic	CH466556.1	EDL16180.1	mixed
mRNA	AK037965.1	BAC29909.1	C57BL/6J
mRNA	AK154349.1	BAE32532.1	NOD
mRNA	AK154736.1	BAE32796.1	NOD
mRNA	AK154849.1	BAE32875.1	NOD
mRNA	BF020112.1	None	C57BL/6J
other-genetic	BC148418.1	AAI48419.1