Ccr1 chemokine (C-C motif) receptor 1 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Ccr1provided by MGI
Official Full Name: chemokine (C-C motif) receptor 1provided by MGI
Primary source: MGI:104618
See related: Ensembl:ENSMUSG00000025804
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cmkbr1; Mip-1a-R

Genomic context

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Location :: 9 F; 9 75.05 cM

Sequence :: Chromosome: 9; NC_000075.6 (123962126..123968692, complement)

See Ccr1 in Epigenomics, MapViewer

Chromosome 9 - NC_000075.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings show that CCR1 is pivotal for bone remodeling induced by mechanical loading during orthodontic tooth movement and these actions depend, at least in part, on CCL3
Title: The effect of CCL3 and CCR1 in bone remodeling induced by mechanical loading during orthodontic tooth movement in mice.
neutrophil Ccr1 amplifies late renal immunopathology and increases mortality in invasive candidiasis by mediating excessive recruitment of neutrophils from the blood to the target organ.
Title: Chemokine receptor Ccr1 drives neutrophil-mediated kidney immunopathology and mortality in invasive candidiasis.
a bis-quinoline compound, (7-chloro-N-(4-(7-chloroquinolin-4-ylamino)butyl)quinolin-4-amine; RE-660) has C-C chemokine receptor type 1 (CCR1)-agonistic properties
Title: Potent adjuvantic activity of a CCR1-agonistic bis-quinoline.
CCR1 functions within the glioblastoma microenvironment through CCR1 and CCR5 in a redundant manner.
Title: CCL5, CCR1 and CCR5 in murine glioblastoma: immune cell infiltration and survival rates are not dependent on individual expression of either CCR1 or CCR5.
The selective interaction of CCL3 with its receptor, CCR1, is critical for radiation-induced lung inflammation and fibrosis, and these conditions can be largely prevented by a small molecule inhibitor of CCR1
Title: The chemokine, CCL3, and its receptor, CCR1, mediate thoracic radiation-induced pulmonary fibrosis.
chemokine receptors CCR1, CCR2 and CCR4 have roles in the pathogenesis of experimental dengue infection in mice
Title: Role of the chemokine receptors CCR1, CCR2 and CCR4 in the pathogenesis of experimental dengue infection in mice.
Data suggest that the CCR1 receptor has a key role in the pathogenesis of smoke-induced inflammation.
Title: The role of the CCR1 receptor in the inflammatory response to tobacco smoke in a mouse model.
These results suggest that peripheral nerve injury elicits the up-regulation of spinal MIP-1alpha and CCR1 to participate in neuropathic pain.
Title: CC-chemokine MIP-1α in the spinal cord contributes to nerve injury-induced neuropathic pain.
the axis of CCR1 and its ligands are likely to be involved in cross-talk between osteoclasts and osteoblasts by modulating the RANK-RANKL-mediated interaction.
Title: Deficiency of chemokine receptor CCR1 causes osteopenia due to impaired functions of osteoclasts and osteoblasts.
Lack of the Ccr1, Mmp2, or Mmp9 gene in the host dramatically suppresses outgrowths of disseminated tumors in the liver.
Title: Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model.

Submit: New GeneRIF Correction See all (46)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_034042.2	NP_035467.1	Ccl3	BIND	PubMed	Ccr1 interacts with Ccl3 (MIP-1-alpha).
NP_034042.2	NP_035467.1	Ccl3	BIND	PubMed	CCR1 interacts with MIP-1-alpha.
NP_034042.2	NP_035467.1	Ccl3	BIND	PubMed	CCR-1 interacts with MIP-1-alpha.
NP_034042.2	NP_038681.1	Ccl5	BIND	PubMed	CCR-1 interacts with RANTES. This interaction was modelled on a demonstrated interaction between mouse CCR-1 and human RANTES.

Pathways from BioSystems

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Chemokine signaling pathway, organism-specific biosystem (from KEGG)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, organism-specific biosystem (from WikiPathways)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, conserved biosystem (from KEGG)
Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
G alpha (i) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
Non-odorant GPCRs, organism-specific biosystem (from WikiPathways)
Non-odorant GPCRs, organism-specific biosystemListing of non-odorant Mouse GCPRs by coupling.
Peptide GPCRs, organism-specific biosystem (from WikiPathways)
Peptide GPCRs, organism-specific biosystem
Peptide GPCRs
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Homology

Homologs of the Ccr1 gene: The Ccr1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
C-C chemokine binding	ISO Inferred from Sequence Orthology more info
C-C chemokine receptor activity	IDA Inferred from Direct Assay more info	PubMed
C-C chemokine receptor activity	ISO Inferred from Sequence Orthology more info
G-protein coupled receptor activity	IEA Inferred from Electronic Annotation more info
chemokine (C-C motif) ligand 5 binding	ISO Inferred from Sequence Orthology more info
chemokine (C-C motif) ligand 7 binding	ISO Inferred from Sequence Orthology more info
chemokine receptor activity	ISO Inferred from Sequence Orthology more info
phosphatidylinositol phospholipase C activity	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
signal transducer activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
G-protein coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
calcium ion transport	ISO Inferred from Sequence Orthology more info
cell-cell signaling	ISO Inferred from Sequence Orthology more info
cellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
chemokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
chemokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
chemotaxis	IEA Inferred from Electronic Annotation more info
elevation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
exocytosis	ISO Inferred from Sequence Orthology more info
immune response	ISO Inferred from Sequence Orthology more info
inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
leukocyte chemotaxis	IDA Inferred from Direct Assay more info	PubMed
leukocyte chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
negative regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
positive regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
positive regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
regulation of fever generation	ISO Inferred from Sequence Orthology more info
response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
external side of plasma membrane	ISO Inferred from Sequence Orthology more info
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
neuronal cell body	ISO Inferred from Sequence Orthology more info
plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-C chemokine receptor type 1

Names: C-C chemokine receptor type 1; CCR-1; CC-CKR-1; RANTES-R; C-C CKR-1; MIP-1 alphaR; MIP-1alpha-R; MIP-1 alpha R; chemokine (C-C) receptor 1; macrophage inflammatory protein 1-alpha receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009912.4 → NP_034042.3 C-C chemokine receptor type 1

Status: VALIDATED

Source sequence(s)

AK031109, AK036597, AK076275

Consensus CDS

CCDS23666.1

UniProtKB/Swiss-Prot

P51675

UniProtKB/TrEMBL

Q8BMH9

UniProtKB/TrEMBL

Q8BVW4

Related

ENSMUSP00000026911, ENSMUST00000026911

Conserved Domains (1) summary

pfam00001
Location:61 – 301
Blast Score: 395

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000075.6 Reference GRCm38.p1 C57BL/6J

Range

123962126..123968692, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000031.1 Alternate Mm_Celera

Range

125030694..125037264

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01082732.1 (2033..8603)	None
genomic	AC140491.4 (39013..45455)	None
genomic	AC192862.1 (9321..15763)	None
genomic	CH466671.2	EDL37173.1	mixed
genomic	U28404.1	AAA89153.1
mRNA	AK031109.1	BAC27256.1	C57BL/6J
mRNA	AK036597.1	BAC29500.1	C57BL/6J
mRNA	AK036690.1	BAC29535.1	C57BL/6J
mRNA	AK076275.1	BAC36284.1	C57BL/6J
mRNA	BC011092.1	AAH11092.1
mRNA	CT010178.1	CAJ18386.1
mRNA	U29678.1	AAA86119.1	C57BL