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Clta clathrin, light polypeptide (Lca) [ Mus musculus (house mouse) ]

Gene ID: 12757, updated on 28-May-2016
Official Symbol
Cltaprovided by MGI
Official Full Name
clathrin, light polypeptide (Lca)provided by MGI
Primary source
MGI:MGI:894297
See related
Ensembl:ENSMUSG00000028478 Vega:OTTMUSG00000007204
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lca; AV026556
Summary
Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Orthologs
Location:
4; 4 B1
Exon count:
9
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (44003816..44032848)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (44025515..44045718)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene GLI pathogenesis-related 2 Neighboring gene calicin Neighboring gene glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Neighboring gene predicted gene 12503

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
clathrin heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
clathrin heavy chain binding ISO
Inferred from Sequence Orthology
more info
 
peptide binding ISO
Inferred from Sequence Orthology
more info
 
structural molecule activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
clathrin-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
clathrin coat ISO
Inferred from Sequence Orthology
more info
 
clathrin coat of coated pit IEA
Inferred from Electronic Annotation
more info
 
clathrin coat of trans-Golgi network vesicle IEA
Inferred from Electronic Annotation
more info
 
clathrin complex ISO
Inferred from Sequence Orthology
more info
 
clathrin vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
 
clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
 
coated pit ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic, membrane-bounded vesicle IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
clathrin light chain A
Names
clathryn light chain (LCA2)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080384.1NP_001073853.1  clathrin light chain A isoform a

    See identical proteins and their annotated locations for NP_001073853.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks alternate in-frame exons, compared to variant 2, resulting in a shorter protein (isoform a), compared to isoform b.
    Source sequence(s)
    AI467006, AK150148, BU847112
    Consensus CDS
    CCDS38748.1
    UniProtKB/TrEMBL
    Q6PFA2
    Related
    ENSMUSP00000127344, ENSMUST00000170241
    Conserved Domains (1) summary
    pfam01086
    Location:20217
    Clathrin_lg_ch; Clathrin light chain
  2. NM_001080385.1NP_001073854.1  clathrin light chain A isoform b

    See identical proteins and their annotated locations for NP_001073854.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (b).
    Source sequence(s)
    AI467006, BU847112, CX243404
    Consensus CDS
    CCDS38746.1
    UniProtKB/TrEMBL
    B1AWD9
    Related
    ENSMUSP00000103483, OTTMUSP00000007656, ENSMUST00000107851, OTTMUST00000016629
    Conserved Domains (1) summary
    pfam01086
    Location:20247
    Clathrin_lg_ch; Clathrin light chain
  3. NM_001080386.1NP_001073855.1  clathrin light chain A isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple in-frame differences in the 5' coding region, compared to variant 2, resulting in a shorter protein (isoform d), compared to isoform b.
    Source sequence(s)
    AI467006, BU847112, CX244279
    Consensus CDS
    CCDS38749.1
    UniProtKB/TrEMBL
    B1AWE0
    Related
    ENSMUSP00000103477, OTTMUSP00000007657, ENSMUST00000107845, OTTMUST00000016630
    Conserved Domains (1) summary
    pfam01086
    Location:20215
    Clathrin_lg_ch; Clathrin light chain
  4. NM_001290470.1NP_001277399.1  clathrin light chain A isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 3' coding region, compared to variant 2. It encodes isoform e, which is shorter than isoform b.
    Source sequence(s)
    AB575971, AK045237, AK149761, BE333066, CK620776
    Consensus CDS
    CCDS71377.1
    UniProtKB/TrEMBL
    B1AWE1, Q6PFA2
    Related
    ENSMUSP00000103479, OTTMUSP00000007658, ENSMUST00000107847, OTTMUST00000016631
    Conserved Domains (1) summary
    pfam01086
    Location:20229
    Clathrin_lg_ch; Clathrin light chain
  5. NM_016760.2NP_058040.2  clathrin light chain A isoform c

    See identical proteins and their annotated locations for NP_058040.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon, compared to variant 2, resulting in a shorter protein (isoform c), compared to isoform b.
    Source sequence(s)
    AI467006, BU847112, CA322069
    Consensus CDS
    CCDS38747.1
    UniProtKB/TrEMBL
    B1AWD8
    Related
    ENSMUSP00000103481, OTTMUSP00000007655, ENSMUST00000107849, OTTMUST00000016628
    Conserved Domains (1) summary
    pfam01086
    Location:20235
    Clathrin_lg_ch; Clathrin light chain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

    Range
    44003816..44032848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537587.2XP_006537650.1  

    See identical proteins and their annotated locations for XP_006537650.1

    UniProtKB/TrEMBL
    B1AWD9
    Conserved Domains (1) summary
    pfam01086
    Location:20247
    Clathrin_lg_ch; Clathrin light chain
  2. XM_006537590.1XP_006537653.1  

    See identical proteins and their annotated locations for XP_006537653.1

    UniProtKB/TrEMBL
    Q6PFA2
    Related
    ENSMUSP00000103478, OTTMUSP00000007654, ENSMUST00000107846, OTTMUST00000016627
    Conserved Domains (1) summary
    pfam01086
    Location:20217
    Clathrin_lg_ch; Clathrin light chain
  3. XM_006537588.2XP_006537651.1  

    Conserved Domains (1) summary
    pfam01086
    Location:20245
    Clathrin_lg_ch; Clathrin light chain

Alternate Mm_Celera

Genomic

  1. AC_000026.1 Alternate Mm_Celera

    Range
    44033842..44054044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)