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Cldn2 claudin 2 [ Mus musculus (house mouse) ]

Gene ID: 12738, updated on 28-May-2016
Official Symbol
Cldn2provided by MGI
Official Full Name
claudin 2provided by MGI
Primary source
MGI:MGI:1276110
See related
Ensembl:ENSMUSG00000047230 Vega:OTTMUSG00000018734
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AL022813
Summary
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The knockout mice lacking this gene display normal appearance, activity, growth and behavior, but are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules. The proteins encoded by this gene and another family member Cldn12 are also critical for vitamin D-dependent Ca2+ absorption between enterocytes. [provided by RefSeq, Aug 2010]
Orthologs
Location:
X; X F1
Exon count:
6
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) X NC_000086.7 (139800808..139811386)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (136335367..136345923)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 8B Neighboring gene ribosomal protein S4, X-linked pseudogene Neighboring gene ripply transcriptional repressor 1 Neighboring gene microrchidia 4 Neighboring gene NMD3 homolog pseudogene Neighboring gene RNA binding motif protein 41

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Hepatitis C, organism-specific biosystem (from KEGG)
    Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Hepatitis C, conserved biosystem (from KEGG)
    Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
    Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
    Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
  • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
    XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016675.4NP_057884.1  claudin-2

    See identical proteins and their annotated locations for NP_057884.1

    Status: REVIEWED

    Source sequence(s)
    AI174044, BC085494, BY075485
    Consensus CDS
    CCDS30437.1
    UniProtKB/Swiss-Prot
    O88552
    Related
    ENSMUSP00000054219, OTTMUSP00000020257, ENSMUST00000054889, OTTMUST00000045068
    Conserved Domains (1) summary
    cl21598
    Location:5181
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p3 C57BL/6J

    Range
    139800808..139811386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528486.2XP_006528549.1  

    See identical proteins and their annotated locations for XP_006528549.1

    Conserved Domains (1) summary
    cl21598
    Location:5181
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
  2. XM_006528487.2XP_006528550.1  

    See identical proteins and their annotated locations for XP_006528550.1

    Conserved Domains (1) summary
    cl21598
    Location:5181
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
  3. XM_006528490.2XP_006528553.1  

    See identical proteins and their annotated locations for XP_006528553.1

    UniProtKB/Swiss-Prot
    O88552
    Conserved Domains (1) summary
    cl21598
    Location:5181
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
  4. XM_006528489.2XP_006528552.1  

    See identical proteins and their annotated locations for XP_006528552.1

    Conserved Domains (1) summary
    cl21598
    Location:5181
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
  5. XM_006528488.1XP_006528551.1  

    See identical proteins and their annotated locations for XP_006528551.1

    Conserved Domains (1) summary
    cl21598
    Location:5181
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
  6. XM_011247729.1XP_011246031.1  

    See identical proteins and their annotated locations for XP_011246031.1

    Conserved Domains (1) summary
    cl21598
    Location:5181
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction

Alternate Mm_Celera

Genomic

  1. AC_000042.1 Alternate Mm_Celera

    Range
    123063424..123074103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)